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ClinicalTrials.gov public records Last synced Oct 26, 2026, 2:28 AM EDT

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Showing 937–960 of 1,015 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Microbiome Clear all
Terminated Not applicable Interventional Accepts healthy volunteers

Yogurt Supplementation to Alter Bone Biomarkers, the Gut Microbiota and Inflammation in Older Adults

NCT05350579
View directory record Official record
Conditions
Osteoporosis, Inflammation
Interventions
Yogurt Intervention
Other
Lead sponsor
University of Massachusetts, Lowell
Other
Eligibility
50 Years and older
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lawrence, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 28, 2022 · Synced Oct 26, 2026, 2:28 AM EDT
Not listed Not applicable Interventional

Prebiotics in Rectal Cancer

NCT05516641
View directory record Official record
Conditions
Rectal Cancer
Interventions
Soluble Corn Fiber, Maltodextrin
Dietary Supplement
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 31, 2023 · Synced Oct 26, 2026, 2:28 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

A Study of the Possible Effects of Medication on Young Onset Colorectal Cancer (YOCRC)

NCT05568420
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Not listed
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years to 49 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 26, 2026, 2:28 AM EDT
Active, not recruiting Not applicable Interventional

Diet and Microbiome Interactions: Application in Posttraumatic Stress Disorder in Adults Consuming Vegetable Drinks

NCT07107269
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder
Interventions
Low diversity plant beverage (Functional Food Intervention), High diversity plant beverage (Functional Food Intervention)
Other
Lead sponsor
Colorado State University
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 26, 2026, 2:28 AM EDT
Terminated Phase 2 Interventional

Continued Safety Evaluation of FB-401 in Children, Adolescents and Adults (2 Years and Older) With Mild to Moderate Atopic Dermatitis Previously Enrolled in the FB401-01 Study

NCT04936113
View directory record Official record
Conditions
Atopic Dermatitis
Interventions
FB-401
Biological
Lead sponsor
Forte Biosciences, Inc.
Industry
Eligibility
2 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
8
States / cities
Fremont, California • Lake City, Florida • Newnan, Georgia + 5 more
Source: ClinicalTrials.gov public record
Updated Oct 28, 2021 · Synced Oct 26, 2026, 2:28 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome

NCT06433115
View directory record Official record
Conditions
Diet Intervention
Interventions
Lean (≥90%) Grass-Fed Beef, Lean (≥90%) Grain-Fed Beef, Plant-Based Meat
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 45 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 26, 2026, 2:28 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pediatric Microbiome Study With Children Now Approximately 8-10 Years Old.

NCT03485755
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Not listed
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
8 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Skillman, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 26, 2019 · Synced Oct 26, 2026, 2:28 AM EDT
Completed Early Phase 1 Interventional

Gut Microbiome Mediated Effects of Inulin Supplementation on Mineral and Bone Metabolism in Hemodialysis Patients

NCT02718885
View directory record Official record
Conditions
Bone Diseases, Endocrine, Nutritional and Metabolic Diseases
Interventions
Inulin, Maltodextrin
Dietary Supplement
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
20 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 2, 2018 · Synced Oct 26, 2026, 2:28 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effects of Crofelemer on the Gut Microbiome in Healthy Volunteers and in HIV+ Patients With Non-Infectious Diarrhea

NCT04192487
View directory record Official record
Conditions
Acquired Immunodeficiency Syndrome, Healthy Volunteers, HIV/AIDS, HIV Diarrhea, Human Immunodeficiency Virus
Interventions
Crofelemer delayed-release tablets 125mg
Drug
Lead sponsor
Napo Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
3
States / cities
Tustin, California • Stratford, Connecticut • Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2021 · Synced Oct 26, 2026, 2:28 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effects of Carboxymethylcellulose Artificial Tears on the Eye Microbiome

NCT05292755
View directory record Official record
Conditions
Dry Eye Syndromes
Interventions
Carboxymethylcellulose (CMC) Artificial Tears, Preservative-free, CMC-free Artificial Tears (control)
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 100 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 20, 2023 · Synced Oct 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Airway Microbiome in Asthma: Relationships to Asthma Phenotype and Inhaled Corticosteroid Treatment

NCT01537133
View directory record Official record
Conditions
Asthma, Atopy
Interventions
fluticasone, Placebo
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
9
States / cities
San Francisco, California • Denver, Colorado • Chicago, Illinois + 6 more
Source: ClinicalTrials.gov public record
Updated Nov 30, 2016 · Synced Oct 26, 2026, 2:28 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Targeted Microbiome Transplant in Atopic Dermatitis

NCT03151148
View directory record Official record
Conditions
Atopic Dermatitis (AD)
Interventions
TMT Lotion, Placebo Lotion
Biological · Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 80 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
San Diego, California • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 17, 2020 · Synced Oct 26, 2026, 2:28 AM EDT
Completed No phase listed Observational

Topical Antisepsis in Head and Neck Cancer Surgery

NCT04721626
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
Chlorhexidine Gluconate, Povidone-iodine, Tetracycline Ointment
Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 7, 2022 · Synced Oct 26, 2026, 2:28 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Exploratory Study of Circadian Relationships Between Social Behavior, Blood Pressure and Metabolomics

NCT02249793
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
25 Years to 35 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 26, 2026, 2:28 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Investigation of Egg Intake and the Relationship Between Gut Microbiome, Metabolic, and Immune Profiles

NCT07844616
View directory record Official record
Conditions
Obesity (BMI Equal to or >30), Immune Function, HDL, Gut Microbiome, Healthy Adult Participants
Interventions
Egg whites, Whole eggs
Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 50 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Oct 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional Results available

Study Of Drinks With Artificial Sweeteners in People With Type 2 Diabetes

NCT03944616
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Diet Beverage, Water
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
35 Years and older
Enrollment
181 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
2
States / cities
Irvine, California • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Oct 26, 2026, 2:28 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Alcoholic Liver Disease and the Gut Microbiome

NCT05007470
View directory record Official record
Conditions
Alcohol Use Disorder, Alcoholic Liver Disease, Microbiome
Interventions
VSL #3 112.5 Capsule, Placebo
Drug · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 6, 2025 · Synced Oct 26, 2026, 2:28 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Gut Organoid and Microbiome Interactions in Hypertension

NCT04497727
View directory record Official record
Conditions
Gut Inflammation, Hypertension
Interventions
Gene Expression
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Oct 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Trimethylamine-N-oxide Production and Metabolism

NCT02558673
View directory record Official record
Conditions
Healthy
Interventions
TMAO dietary precursors, Control (or active comparator)
Other
Lead sponsor
Cornell University
Other
Eligibility
21 Years to 50 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2016 · Synced Oct 26, 2026, 2:28 AM EDT
Completed Phase 1 Interventional

Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)

NCT02707042
View directory record Official record
Conditions
Normal Physiology, Healthy
Interventions
Amoxicillin, Azithromycin, Control
Drug · Other
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 49 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Oral Fructanase Administration on Gastrointestinal Symptoms After Inulin Challenge in Healthy Adults

NCT06628869
View directory record Official record
Conditions
Digestive Health, Gastrointestinal Health, FODMAP Intolerance, Food Sensitivity
Interventions
Fructanase, Maltodextrin placebo
Dietary Supplement
Lead sponsor
BIO-CAT, Inc.
Industry
Eligibility
20 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 26, 2026, 2:28 AM EDT
Active, not recruiting Not applicable Interventional Results available

Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components

NCT05318183
View directory record Official record
Conditions
PreDiabetes, Dysbiosis, Endotoxemia, Inflammation
Interventions
Whole Wheat Bread, White Bread (control)
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Oct 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Diet on the Gut-Muscle Axis in Older Adults

NCT05549622
View directory record Official record
Conditions
Sarcopenia, Dietary Exposure, Microbial Colonization
Interventions
Low-soluble fiber diet, High-soluble fiber diet
Other
Lead sponsor
Tufts University
Other
Eligibility
65 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 18, 2025 · Synced Oct 26, 2026, 2:28 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluating Response to Vitamin D3 and K2 Supplementation in Healthcare Personnel

NCT07199829
View directory record Official record
Conditions
Hypovitaminosis D, Hypovitaminosis
Interventions
Vitamin Arm 1, Vitamin Arm 2, Vitamin Arm 3, Placebo
Dietary Supplement · Other
Lead sponsor
Madigan Army Medical Center
Federal
Eligibility
18 Years to 69 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Sep 30, 2025 · Synced Oct 26, 2026, 2:28 AM EDT