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ClinicalTrials.gov public records Last synced Oct 21, 2026, 12:46 AM EDT

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Showing 145–168 of 1,014 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Microbiome Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Early Avocado Exposure on Development and the Gut Microbiome in American Hispanic Infants

NCT06876935
View directory record Official record
Conditions
Gut Microbiome, Neurocognitive Correlates of Eating Habits, Infant Growth
Interventions
Daily avocado
Other
Lead sponsor
Arizona State University
Other
Eligibility
3 Months to 6 Months
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Oct 21, 2026, 12:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Study to Assess the Effect of Novel Glycans on Nitrogen Metabolism of the Gut in Healthy Subjects

NCT04603378
View directory record Official record
Conditions
Healthy
Interventions
KB195, Polydextrose, Pullulan, Maltodextrin
Other
Lead sponsor
Kaleido Biosciences
Industry
Eligibility
18 Years to 50 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 26, 2020 · Synced Oct 21, 2026, 12:46 AM EDT
Completed Not applicable Interventional

Edible Insects: Good for the Gut and the Globe

NCT06397924
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Chitin Fiber, Placebo
Dietary Supplement
Lead sponsor
Colorado State University
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 24, 2025 · Synced Oct 21, 2026, 12:46 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP)

NCT02782325
View directory record Official record
Conditions
Pouchitis
Interventions
Active FMT, then open label FMT, Placebo FMT, then open label FMT
Biological
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 14, 2019 · Synced Oct 21, 2026, 12:46 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Got Doxy- 'Flipping the Script' on STI PEP

NCT07215325
View directory record Official record
Conditions
Sexually Transmitted Infections (STI)
Interventions
Doxycycline monohydrate 200 mg, Observation
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older · Male only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Oct 21, 2026, 12:46 AM EDT
Recruiting Not applicable Interventional

The Food Environment, Microbial Cysteine Metabolism, and Cancer Disparities

NCT07086833
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Low Cysteine Diet, High Cysteine Diet
Other
Lead sponsor
Purdue University
Other
Eligibility
45 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Indianapolis, Indiana • West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 21, 2026, 12:46 AM EDT
Recruiting Phase 2 Interventional

Neoadjuvant Immune Checkpoint Blockade + a Prebiotic Food-enriched Dietary Intervention to Optimize Immune Response in Melanoma: NEO-PreFED

NCT06548789
View directory record Official record
Conditions
Melanoma
Interventions
Prebiotic Xnack Packouts
Dietary Supplement
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 21, 2026, 12:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages

NCT02856776
View directory record Official record
Conditions
Vitamin D Insufficiency
Interventions
Vitamin D3
Dietary Supplement
Lead sponsor
Boston University
Other
Eligibility
18 Years to 50 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 18, 2019 · Synced Oct 21, 2026, 12:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Analysis of MicroBial Metabolites After Eating Refined Food

NCT04308473
View directory record Official record
Conditions
Dietary Habits
Interventions
Ultra-processed Food Meal, Whole Food Meal
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 21, 2026, 12:46 AM EDT
Completed Phase 2 Interventional Results available

The Effects of Patiromer on Serum Potassium Level and Gut Microbiome of ESRD Patients With Hyperkalemia

NCT03326583
View directory record Official record
Conditions
ESRD, Hyperkalemia, End Stage Renal Disease
Interventions
Patiromer
Drug
Lead sponsor
Dominic Raj
Other
Eligibility
18 Years to 85 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Oct 21, 2026, 12:46 AM EDT
Completed No phase listed Observational

Study of Variation Over Time in the Oral Microbiome

NCT02049398
View directory record Official record
Conditions
Microbiota, Oral Health, Body Mass Index
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 27, 2020 · Synced Oct 21, 2026, 12:46 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Microbiome, Anxiety and Cognitive Orientation Study

NCT05388630
View directory record Official record
Conditions
Anxiety, Microbiome, Mood Disorders, Neurodegeneration, Depression
Interventions
Not listed
Lead sponsor
Endominance
Industry
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Dec 14, 2022 · Synced Oct 21, 2026, 12:46 AM EDT
Recruiting Phase 2 Interventional

Trial Targeting Gut Bacterial Androgen Production to Reverse Therapeutic Resistance to Abiraterone in Patients With Metastatic Prostate Cancer

NCT06616597
View directory record Official record
Conditions
Prostate Cancer (Adenocarcinoma), Metastatic Prostate Cancer
Interventions
Abiraterone acetate, Dexamethasone, Metronidazole
Drug
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other
Eligibility
18 Years and older · Male only
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 21, 2026, 12:46 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Red Light Photobiomodulation and Topical Disinfectants

NCT05797818
View directory record Official record
Conditions
Healthcare Associated Infection, Nosocomial Infection, Surgical Site Infection
Interventions
Methylene Blue Only, Chlorhexidine Gluconate Only, Methylene Blue + Chlorhexidine Gluconate, Light Only
Device
Lead sponsor
Ondine Biomedical Inc.
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Bothell, Washington
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Oct 21, 2026, 12:46 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Diet and Microbiome Longitudinal Monitoring With Food Intervention

NCT04758715
View directory record Official record
Conditions
Microbiome, Human, Gastrointestinal Tract
Interventions
Food provided from a commercial meal service provider for a week
Other
Lead sponsor
University of Nebraska Lincoln
Other
Eligibility
19 Years and older
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2030
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 21, 2026, 12:46 AM EDT
Not listed Not applicable Interventional

Viome Precision Nutritional Programs to Improve Clinical Outcomes for Mental Health Disorders

NCT06502717
View directory record Official record
Conditions
Mental Health Issue, Depression, Anxiety
Interventions
VIOME Precision Nutrition Program
Combination Product
Lead sponsor
Viome
Industry
Eligibility
25 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Bothell, Washington
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Oct 21, 2026, 12:46 AM EDT
Withdrawn No phase listed Observational

Diet, Physical Activity and Body Composition Changes During R-CHOP

NCT04293900
View directory record Official record
Conditions
Non-Hodgkin Lymphoma, DLBCL, Diffuse Large B Cell Lymphoma
Interventions
24-hour dietary recall, Hand grip strength, International Physical Activity Questionnaire, Patient-reported outcomes survey, Pittsburgh Sleep Quality Index, Functional Assessment of Cancer Treatment - Lymphoma, urine sample (optional), fecal sample (optional)
Other
Lead sponsor
George Washington University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 6, 2020 · Synced Oct 21, 2026, 12:46 AM EDT
Terminated Phase 1 Interventional Results available

Targeted Investigation of Microbiome Elimination

NCT05177328
View directory record Official record
Conditions
Atopic Dermatitis
Interventions
S. hominis A 9 Product, Placebo
Biological · Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 12, 2024 · Synced Oct 21, 2026, 12:46 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Ocular Surface Dry Eye Microbiome

NCT02306668
View directory record Official record
Conditions
Dry Eyes
Interventions
Not listed
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 3, 2014 · Synced Oct 21, 2026, 12:46 AM EDT
Completed Phase 1Phase 2 Interventional

FMT in Pediatric Crohn's Disease

NCT03194529
View directory record Official record
Conditions
Crohn Disease, Pediatric Crohns Disease
Interventions
FMT
Biological
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
7 Years to 21 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 13, 2020 · Synced Oct 21, 2026, 12:46 AM EDT
Recruiting Not applicable Interventional

Study Using Prebiotics to Improve Gut Microbiome Diversity After Autologous Cellular Therapy

NCT05135351
View directory record Official record
Conditions
Multiple Myeloma, Lymphoma
Interventions
Resistant Starch, Maltodextrin
Dietary Supplement
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 21, 2026, 12:46 AM EDT
Not listed Not applicable Interventional

Gastrointestinal Microbiome Study of Appendiceal Cancer

NCT02599116
View directory record Official record
Conditions
Pseudomyxoma Peritonei, Appendiceal Neoplasm, Cancer, Appendiceal
Interventions
Bio-specimen collection, Questionnaire
Other
Lead sponsor
Mercy Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 27, 2023 · Synced Oct 21, 2026, 12:46 AM EDT
Recruiting Phase 2 Interventional

Adding a Live Biotherapeutic Product (CBM588) to Pembrolizumab for the Treatment of Renal Cell Cancer After Surgery

NCT07037004
View directory record Official record
Conditions
Clear Cell Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Stage II Renal Cell Cancer AJCC v8, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8
Interventions
Biospecimen Collection, Clostridium butyricum CBM588 Strain, Computed Tomography, Pembrolizumab
Procedure · Drug · Biological
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Duarte, California • Irvine, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 21, 2026, 12:46 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Irritable Bowel Syndrome and Control Volunteers: Diet Challenge

NCT03983434
View directory record Official record
Conditions
IBS - Irritable Bowel Syndrome
Interventions
Inulin
Dietary Supplement
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Oct 21, 2026, 12:46 AM EDT