Independent directory Public ClinicalTrials.gov records United States
Clear filters
ClinicalTrials.gov public records Last synced Sep 1, 2026, 8:24 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 45 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
PTSD
Interventions
Midomafetamine, Manualized therapy
Drug · Behavioral
Lead sponsor
Resilient Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
12
States / cities
North Hollywood, California • San Francisco, California • Boulder, Colorado + 7 more
Completed Phase 2 Interventional Accepts healthy volunteers

Social Anxiety MDMA-Assisted Therapy Investigation

NCT05138068
Conditions
Social Anxiety Disorder
Interventions
MDMA, Psychotherapy
Drug · Behavioral
Lead sponsor
Jason B Luoma
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Conditions
Posttraumatic Stress Disorder
Interventions
Therapy, Midomafetamine, Placebo
Behavioral · Drug
Lead sponsor
Resilient Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
12
States / cities
Los Angeles, California • San Francisco, California • Boulder, Colorado + 7 more
Completed No phase listed Observational Accepts healthy volunteers

Stanford Regulating Circuits of the Brain Study - MDMA

NCT04060108
Conditions
Healthy
Interventions
MDMA
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 55 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Palo Alto, California
Conditions
Posttraumatic Stress Disorder
Interventions
Midomafetamine, Therapy
Drug · Behavioral
Lead sponsor
Resilient Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Mt. Pleasant, South Carolina
Conditions
MDMA Discontinuation Syndrome
Interventions
3,4-methylenedioxymethamphetamine or Placebo
Drug
Lead sponsor
California Pacific Medical Center Research Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
San Francisco, California
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Pharmacology of MDA [3,4-methylenedioxyamphetamine]

NCT00823407
Conditions
Healthy
Interventions
MDA, Placebo
Drug
Lead sponsor
California Pacific Medical Center Research Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
San Francisco, California
Conditions
Posttraumatic Stress Disorder
Interventions
Low dose MDMA-assisted therapy, Medium dose MDMA-assisted therapy, Full dose MDMA-assisted therapy, Therapy
Drug · Behavioral
Lead sponsor
Resilient Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Mt. Pleasant, South Carolina
Conditions
Borderline Personality Disorder
Interventions
MDMA
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Conditions
Post Traumatic Stress Disorder, Combat Stress Disorders
Interventions
3,4-methylenedioxymethamphetamine
Drug
Lead sponsor
VA Loma Linda Health Care System
Federal
Eligibility
18 Years to 55 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Loma Linda, California
Conditions
Post Traumatic Stress Disorder
Interventions
3,4-methylenedioxymethamphetamine, d-amphetamine, Therapy
Drug · Behavioral
Lead sponsor
Stephen Robert Marder
Federal
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Los Angeles, California
Active, not recruiting Early Phase 1 Interventional

MDMA-Assisted Therapy for Pathological Narcissism

NCT06565494
Conditions
Narcissism
Interventions
midomafetamine (MDMA)-Assisted Therapy
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 64 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Conditions
Autism Spectrum Disorder, ASD
Interventions
DT402 (R-enantiomer of 3,4-methylenedioxymethamphetamine (MDMA))
Drug
Lead sponsor
Definium Therapeutics US, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Conditions
Post Traumatic Stress Disorder, Alcohol Use Disorder
Interventions
Full Dose MDMA, MDMA-Assisted psychotherapy, Active Placebo Dose MDMA
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
2
States / cities
West Haven, Connecticut • Providence, Rhode Island
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Effect of Stimulant Drugs on Social Perception

NCT03790618
Conditions
Healthy, MDMA ('Ecstasy')
Interventions
3,4-Methylenedioxymethamphetamine, methamphetamine
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 35 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

MDMA-Assisted Cognitive-Behavioral Conjoint Therapy (CBCT) in Dyads in Which 1 Member Has Chronic PTSD

NCT02876172
Conditions
Posttraumatic Stress Disorder
Interventions
MDMA, CBCT, Therapy
Drug · Behavioral
Lead sponsor
Resilient Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Mt. Pleasant, South Carolina
Conditions
Obsessive-Compulsive Disorder
Interventions
3,4-Methyl enedioxy methamphetamine, Methamphetamine, Cognitive Behavioral Therapy (CBT)
Drug · Behavioral
Lead sponsor
Carolyn Rodriguez
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Conditions
Posttraumatic Stress Disorder
Interventions
Midomafetamine, Psychotherapy
Drug · Behavioral
Lead sponsor
Bronx VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
The Bronx, New York
Conditions
Pharmacokinetics, Hepatic Impairment
Interventions
Midomafetamine HCl
Drug
Lead sponsor
Resilient Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Knoxville, Tennessee
Completed Phase 1 Interventional Accepts healthy volunteers

Neurobiology and Pharmacokinets of Acute MDMA Administration

NCT01148342
Conditions
Substance-Related Disorders
Interventions
MDMA, (+/-)3,4-methylenedioxymethamphetamine Hydrochloride, MDMA HCI Capsules
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 40 Years
Enrollment
187 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Conditions
PTSD
Interventions
MDMA, Group Therapy
Drug · Behavioral
Lead sponsor
Portland VA Research Foundation, Inc
Other
Eligibility
18 Years to 64 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Vancouver, Washington
Conditions
Post-Traumatic Stress Disorder
Interventions
3,4 Methylenedioxymethamphetamine, Prolonged Exposure
Drug · Behavioral
Lead sponsor
Healing Breakthrough
Other
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Diego, California
Conditions
Posttraumatic Stress Disorder
Interventions
Midomafetamine HCl, Lactose placebo pill, Therapy
Drug · Behavioral
Lead sponsor
Resilient Pharmaceuticals
Industry
Eligibility
18 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Mt. Pleasant, South Carolina
Conditions
Post Traumatic Stress Disorder
Interventions
Midomafetamine, Psychotherapy
Drug · Behavioral
Lead sponsor
Resilient Pharmaceuticals
Industry
Eligibility
18 Years and older
U.S. locations
2
States / cities
Rockville, Maryland • Waynesville, North Carolina