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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Mixed meal tolerance testing Clear all
Recruiting Phase 1 Interventional Accepts healthy volunteers

Alpelisib Challenge Test (ACT)

NCT07778524
View directory record Official record
Conditions
Insulin Resistance, Type 2 Diabetes, Obesity & Overweight, Healthy Adult Participants
Interventions
Alpelisib 300 mg, Alpelisib Challenge Test (ACT): Mixed Meal Tolerance Test (MMTT) after taking alpelisib, Hyperglycemic clamp
Drug · Diagnostic Test
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 25, 2026, 7:19 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Identification of Phenotypic Factors That Predict Success for Weight Loss and Long-term Weight Maintenance

NCT02043457
View directory record Official record
Conditions
Obesity
Interventions
phenotyping
Other
Lead sponsor
University of Michigan
Other
Eligibility
15 Years to 75 Years
Enrollment
3,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2030
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 25, 2026, 7:19 PM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal Tolerance

NCT04532801
View directory record Official record
Conditions
Insulin, Glucose, Healthy Volunteers, Women, Pregnancy
Interventions
Kisspeptin-10, mixed meal tolerance test
Drug · Other
Lead sponsor
Stephanie B. Seminara, MD
Other
Eligibility
18 Years to 40 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 31, 2024 · Synced Sep 25, 2026, 7:19 PM EDT
Not listed Not applicable Interventional

A Pilot and Feasibility Study to Evaluate High vs Low Glycemic Index Mixed Meal Tolerance Test in Adolescents and Young Adults With Cystic Fibrosis

NCT06350149
View directory record Official record
Conditions
Cystic Fibrosis
Interventions
Sugar Sweetened Beverages (SSB), Hi GI, Lo GI
Other
Lead sponsor
Emory University
Other
Eligibility
12 Years to 21 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 4, 2024 · Synced Sep 25, 2026, 7:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Avocado and Postprandial Responses

NCT06818032
View directory record Official record
Conditions
Healthy, Healthy Volunteer, Healthy Volunteers, Healthy Adult, Healthy Male and Female Subjects, Healthy Subjects, Healthy Volunteers Only, Healthy Non-smokers
Interventions
Negative control, Avocado, Fat and fiber addition
Other
Lead sponsor
University of Vermont Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 25, 2026, 7:19 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sleep and Metabolism

NCT05775627
View directory record Official record
Conditions
Sleep Deprivation, Obesity, Glucose Intolerance, Weight Gain, Food Selection
Interventions
Sleep Restriction
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Sep 25, 2026, 7:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

ImpaCt Of Shiftwork on METabolic Flexibility and Skeletal Muscle Clocks

NCT05820490
View directory record Official record
Conditions
Metabolic Health
Interventions
Whole Room Calorimeter, Mixed-Meal Tolerance Test (MMTT), Core Body Temperature, Morningness-Eveningness Questionnaire, Muscle Biopsy, Serial Blood Sampling
Other · Procedure
Lead sponsor
AdventHealth Translational Research Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 25, 2026, 7:19 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

NCT04055428
View directory record Official record
Conditions
Diabetes Mellitus, Cardiovascular Diseases, Insulin Sensitivity/Resistance, Metabolic Disease, Natriuretic Peptides, Metabolism, Energy Expenditure
Interventions
Sacubitril, Valsartan 97-103 mg Oral Tablet, Valsartan 160 mg, Intravenous Glucose Tolerance Test, Standardized Meals, Exercise capacity VO2 maximum determination
Drug · Other · Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Sep 25, 2026, 7:19 PM EDT
Completed Phase 1 Interventional

Glucose Metabolism in the Immediate and Short Term Follow up After Bariatric Surgery

NCT00488423
View directory record Official record
Conditions
Diabetes, Gastric Bypass
Interventions
Mixed Meal Tolerance test, Hyperglycemic clamp
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
19 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 21, 2011 · Synced Sep 25, 2026, 7:19 PM EDT
Recruiting Phase 2 Interventional

GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance

NCT04731272
View directory record Official record
Conditions
Cystic Fibrosis, Pancreatic Insufficiency, Abnormal Glucose Tolerance, Diabetes
Interventions
Dulaglutide 0.75Mg/0.5Ml Inj Pen
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
2
States / cities
Aurora, Colorado • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 25, 2026, 7:19 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Diabetes/ Endocrine Surveillance in SDS

NCT04275479
View directory record Official record
Conditions
Shwachman-Diamond Syndrome
Interventions
Oral Glucose Tolerance Test, Modified Oral Glucose Tolerance Test, Modified Mixed Meal Tolerance Test, Continuous Glucose Monitor, Food Diary, Medical History Questionnaires
Diagnostic Test · Other · Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
3 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 18, 2024 · Synced Sep 25, 2026, 7:19 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Closed-Loop Glucagon Pump for Treatment of Post-Bariatric Hypoglycemia

NCT03255629
View directory record Official record
Conditions
Post-bariatric Hypoglycemia
Interventions
glucagon, Closed loop glucagon pump
Drug · Device
Lead sponsor
Joslin Diabetes Center
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 5, 2022 · Synced Sep 25, 2026, 7:19 PM EDT
Completed Not applicable Interventional Results available

Role of Glucagon-Like Peptide-1 in Postprandial Hypoglycemia

NCT01162499
View directory record Official record
Conditions
Postprandial Hypoglycemia
Interventions
Exendin-(9-39), Vehicle
Drug · Other
Lead sponsor
Diva De Leon
Other
Eligibility
6 Months to 18 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 22, 2017 · Synced Sep 25, 2026, 7:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cardiovascular and Metabolic Responses to a Mixed Meal

NCT00882986
View directory record Official record
Conditions
Insulin Resistance
Interventions
Not listed
Lead sponsor
John Thyfault
Other
Eligibility
20 Years to 50 Years · Male only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2015 · Synced Sep 25, 2026, 7:19 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Role of Glucagon In Glucose Control in Cystic Fibrosis Related Diabetes

NCT02398383
View directory record Official record
Conditions
Cystic Fibrosis, Cystic Fibrosis Related Diabetes
Interventions
Oral Glucose Tolerance Test, Mixed Meal Tolerance Test, Hypoglycemic Clamp
Other
Lead sponsor
Yale University
Other
Eligibility
12 Years to 45 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 25, 2020 · Synced Sep 25, 2026, 7:19 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Fasting Predictors of OGTT and MMTT Response

NCT01998867
View directory record Official record
Conditions
Prediabetes, Hypertension, Obesity, Cardiovascular Disease
Interventions
Not listed
Lead sponsor
Health Diagnostic Laboratory, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 12, 2015 · Synced Sep 25, 2026, 7:19 PM EDT
Completed No phase listed Observational

Glycemic Index in Mitochondrial Disease

NCT02284334
View directory record Official record
Conditions
Mitochondrial Diseases
Interventions
test meal
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
7 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 19, 2020 · Synced Sep 25, 2026, 7:19 PM EDT
Active, not recruiting Phase 1 Interventional

Physiologic Markers of Cardiometabolic Risk in People With Type 1 Diabetes

NCT06105931
View directory record Official record
Conditions
type1diabetes, Obesity
Interventions
Hyperinsulinemic-euglycemic clamp, High Fat Mixed Meal Tolerance Test
Biological · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 30 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 25, 2026, 7:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Understanding Effects of Calcium on the Gut-Bone Axis

NCT06383117
View directory record Official record
Conditions
Healthy, Adult, Calcium, Bone Resorption, Endocrine; Obesity
Interventions
Calcium carbonate, Placebo Control
Dietary Supplement
Lead sponsor
University of Georgia
Other
Eligibility
18 Years to 45 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Sep 25, 2026, 7:19 PM EDT
Completed Early Phase 1 Interventional Results available

Pancreatic Enzyme Replacement and Glucose Regulation in Type 1 Diabetes

NCT05266963
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
CREON, Placebo
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Sep 25, 2026, 7:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Postprandial Inflammation and Nuts (PIN) in Older Adults

NCT06348771
View directory record Official record
Conditions
Healthy Aging, Overweight and Obesity
Interventions
monounsaturated fatty acids (MUFA) peanut meal
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
55 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Sep 25, 2026, 7:19 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Role of Nutrient Transit in Hyperinsulinemic Hypoglycemia

NCT04615546
View directory record Official record
Conditions
Post-Bariatric Hypoglycemia
Interventions
Use of Continuous Glucose Monitor (CGM), Use of "Cardea Solo" monitoring
Behavioral · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 3, 2024 · Synced Sep 25, 2026, 7:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Egg Consumption on Carotenoid Absorption From Co-consumed, Non-Egg Food

NCT01951313
View directory record Official record
Conditions
Will Consuming Eggs With a Mixed Vegetable Salad Increase Carotenoid Absorption
Interventions
Egg consumption
Other
Lead sponsor
Purdue University
Other
Eligibility
19 Years to 45 Years · Male only
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 17, 2014 · Synced Sep 25, 2026, 7:19 PM EDT
Recruiting Early Phase 1 Interventional

GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab

NCT06338553
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
Semaglutide (Rybelsus®), Placebo
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
12 Years to 50 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Sep 25, 2026, 7:19 PM EDT