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These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 16, 2026, 8:00 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–112 of 112 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Modafinil Placebo Clear all

Conditions: Obesity, Premature Recovery From Anesthesia
Interventions: Nuvigil, Placebo; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Healthy
Interventions: LY3154207, Placebo, Modafinil; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 18 Years and older · Male only
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Glendale, California

Conditions: Sleep Deprivation, Cold Exposure
Interventions: Modafinil (M), 200 mg Microcrystalline Cellulose; Drug
Lead sponsor: United States Army Research Institute of Environmental Medicine; Federal
Eligibility: 17 Years to 39 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Natick, Massachusetts

Conditions: Lung Cancer
Interventions: Armodafinil, Placebo, Minocycline, Questionnaires; Drug · Other · Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Healthy
Interventions: modafinil, methylphenidate, lorazepam, placebo; Drug
Lead sponsor: Orasi Medical, Inc.; Industry
Eligibility: 18 Years to 35 Years · Male only
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 1
States / cities: Elk Grove Village, Illinois

Conditions: Binge Eating Disorder, Overweight, Obese
Interventions: Armodafinil, Matching placebo; Drug
Lead sponsor: Lindner Center of HOPE; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: Mason, Ohio

Conditions: Traumatic Brain Injury
Interventions: Armodafinil, Placebo; Drug · Other
Lead sponsor: Cephalon, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 117 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 68
States / cities: Birmingham, Alabama • Tucson, Arizona • Hot Springs, Arkansas + 53 more

Conditions: Apathy, Alzheimer's Disease
Interventions: Modafinil, Placebo; Drug
Lead sponsor: Brown University; Other
Eligibility: 65 Years to 95 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Cancer, Fatigue, Chemotherapy
Interventions: Modafinil, sugar pill; Drug
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Esophageal Cancer
Interventions: Armodafinil, Placebo, Minocycline, Questionnaires; Drug · Other · Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Parkinson Disease
Interventions: THN102 Dosage A, THN102 Dosage B, THN102 Dosage C; Drug
Lead sponsor: Theranexus; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 77 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 3
States / cities: Kansas City, Kansas • Boston, Massachusetts • Houston, Texas

Conditions: Fibromyalgia, Primary
Interventions: armodafinil, placebo; Drug
Lead sponsor: State University of New York - Upstate Medical University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Syracuse, New York

Conditions: Attention Deficit Hyperactivity Disorder, ADHD
Interventions: Modafinil; Drug
Lead sponsor: Cephalon; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 370 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 18
States / cities: Little Rock, Arkansas • Lafayette, California • Northridge, California + 15 more

Conditions: Healthy, Narcolepsy
Interventions: MK-6552, MK-6552 placebo, Modafinil, Modafinil placebo; Drug
Lead sponsor: Merck Sharp & Dohme LLC; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 2
States / cities: Atlanta, Georgia • Eatontown, New Jersey

Conditions: Attention Deficit Hyperactivity Disorder
Interventions: Modafinil; Drug
Lead sponsor: Cephalon; Industry
Eligibility: 6 Years to 17 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006
U.S. locations: 23
States / cities: Little Rock, Arkansas • Irvine, California • San Francisco, California + 20 more

Conditions: Cognition
Interventions: Modafinil 200mg, mixed amphetamine salts, Placebo; Drug
Lead sponsor: United States Army Aeromedical Research Laboratory; Federal
Eligibility: 18 Years to 40 Years · Male only
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Fort Rucker, Alabama

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Armodafinil (Nuvigil), Postoperative Recovery of OSA (Obstructive Sleep Apnea) and Obese Patients

A Study of LY3154207 on Sleep in Healthy Male Participants

Modafinil to Optimize the Performance of Cold-Stressed Sleep-Deprived Personnel

A Study for Reducing Symptom Burden Produced by Chemoradiation Treatment for Non Small Cell Lung Cancer by Minocycline and Armodafinil

Acute Effect of Three Neuroactive Drugs Measured by Magnetoencephalography (MEG), Electroencephalography (EEG) and the Synchronous Neural Interaction Test

Armodafinil in Binge Eating Disorder (BED)

Study to Evaluate the Efficacy and Safety of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury

Treatment of Apathy in Alzheimer's Disease With Modafinil

Modafinil to Reduce Persistent Fatigue in Patients Following Treatment for Cancer

A Phase II Study of Minocycline and Armodafinil for Reducing the Symptom Burden Produced by Chemoradiation Treatment for Esophageal Cancer

Safety and Efficacy of THN102 in Patients With Parkinson's Disease and Excessive Daytime Sleepiness

An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue

Dose-Finding Study to Evaluate the Efficacy and Safety of Modafinil as Treatment for Adults With ADHD

A Study of MK-6552 in Sleep Deprived Healthy Participants (MK-6552-003)

Study to Evaluate the Efficacy of Modafinil Treatment in Patients With Attention Deficit Hyperactivity Disorder (ADHD) Who Are Responders to Modafinil Treatment

Enhancing Operational Performance in Healthy Rested Soldiers With Pharmacological Stimulants