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ClinicalTrials.gov public records Last synced Nov 11, 2026, 9:24 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Moderate Fat and Moderate Carbohydrate Diet Clear all

Conditions: Obesity
Interventions: Low carbohydrate diet, Moderate carbohydrate diet, High carbohydrate diet; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 4
States / cities: Boston, Massachusetts • Framingham, Massachusetts

Conditions: Liver Transplantation, Metabolic Syndrome X, Obesity
Interventions: Control group, Mediterranean diet, Protein-Sparing Modified Fast (PSMF); Other
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Rheumatoid Arthritis (RA), Crohn's Disease (CD), Ulcerative Colitis (UC)
Interventions: Ketogenic diet, Carnivore (Lion) Diet; Behavioral
Lead sponsor: Fuller Research Foundation; Other
Eligibility: 18 Years to 64 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Long COVID Fatigue
Interventions: Ketogenic Metabolic Therapy, Lifestyle Intervention; Other · Behavioral
Lead sponsor: National University of Natural Medicine; Other
Eligibility: 18 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Diet Modification, Lung Cancer
Interventions: Special Diet Therapy (low-carb), Special Diet Therapy (low-fat), Special Diet Therapy (USDA control); Behavioral
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Obesity, Insulin Resistance
Interventions: Weight loss with very low fat plant-based diet and regular exercise; Other
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Ketogenic Diet, Weight Loss
Interventions: Diet, Blood Draw, Ketone/Glucose Monitoring, Body Composition, Urine Analysis, Neuropsychological Measures - ANAM; Other · Biological · Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: PCOS (Polycystic Ovary Syndrome)
Interventions: Ketogenic diet, Exogenous Ketone Supplement; Other · Dietary Supplement
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Obesity, Insulin Resistance
Interventions: Mediterranean diet, Low-carbohydrate, ketogenic diet, Low-fat diet, Annual follow-up testing for 5 years; Behavioral · Other
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2029
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Overweight
Interventions: Dietary Supplements and TR90 Eating Plan, Placebo and Low Fat Eating Plan; Dietary Supplement
Lead sponsor: Pharmanex; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 141 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Logan, Utah

Conditions: Metabolic Syndrome X, Obesity, Insulin Resistance, Hypertension, Diabetes
Interventions: The DASH diet, The low glycemic Index Diet, Reduced calorie American Diet; Behavioral
Lead sponsor: Rockefeller University; Other
Eligibility: 18 Years to 45 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Diabetes Mellitus, Type 1
Interventions: high GI meal, low GI meal, euglycemic insulin clamp, primed-variable insulin infusion; Other · Drug
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 45 Years · Male only
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Hypertriglyceridemia, Diabetes Mellitus
Interventions: Low Fat/High Carbohydrate, High Monounsaturated Fat/Low Carbohydrate; Other
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years to 75 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2005
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Traumatic Brain Injury
Interventions: Ketogenic Diet; Other
Lead sponsor: Gillette Children's Specialty Healthcare; Other
Eligibility: 2 Years to 17 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Saint Paul, Minnesota

Conditions: Intra-Abdominal Fat
Interventions: IER+MED, MED/DER; Behavioral
Lead sponsor: University of Hawaii; Other
Eligibility: 35 Years to 69 Years
Enrollment: 260 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Enteric Hyperoxaluria
Interventions: Moderately High Oxalate (MOx) Diet; Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 80 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Obesity, Diabetes, Cardiovascular Disease
Interventions: Feeding study; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 234 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Framingham, Massachusetts

Conditions: Metabolic Syndrome X, Dyslipidemias
Interventions: Moderate Fat and Moderate Carbohydrate Diet, Low Fat and High Carbohydrate Diet; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 30 Years to 75 Years
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Diet Therapy
Interventions: Western Diet, CLEAN-MED; Other
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Overweight, Obesity
Interventions: Meditation; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 12 Years to 15 Years
Enrollment: 53 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Alzheimer Disease
Interventions: Ketogenic Diet, Therapeutic Lifestyles Changes Diet; Behavioral
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 50 Years to 90 Years
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Fairway, Kansas

Conditions: B-cell Acute Lymphoblastic Leukemia, Obesity
Interventions: IDEAL2 Intervention; Behavioral
Lead sponsor: Etan Orgel; Other
Eligibility: 7 Years to 25 Years
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2032
U.S. locations: 16
States / cities: Los Angeles, California • Orange, California • San Francisco, California + 13 more

Conditions: Schizophrenia, Schizophrenia and Related Disorders, Bipolar Disorder, Bipolar and Related Disorders, Major Depressive Disorder, Major Depression Severe, Ketogenic Dieting, Ketosis, Metabolic Disease, Metabolic Syndrome
Interventions: LCHF Ketogenic Diet, Diet-as-Usual (DAU); Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: PreDiabetes, Sedentary Lifestyle
Interventions: 6-week exercise training program, Standardized isoenergetic high fat diet; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 60 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 2
States / cities: Winston-Salem, North Carolina

Search by objective public record fields.

Metabolic Fuels Study

Mediterranean Diet and Protein-Sparing Modified Diet for Metabolic Syndrome in Liver Transplant Recipients

Ketogenic and Carnivore (Lion) Diets for Inflammatory Bowel Disease and Rheumatoid Arthritis

Fully Remote, Telehealth-based Ketogenic Metabolic Therapy for Long COVID

Reducing Insulin, Growth Hormones, and Tumors

Effects of a Calorie Restricted, Very Low Fat Plant-based Diet and Multi-component Exercise Program on Metabolic Health

Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.

Symptoms of Polycystic Ovarian Syndrome Ameliorated by Keto-Adaptation Pilot

Precision Nutrition and Metabolic Function

A Prospective Study Investigating the Effects of a Novel Weight Management Program

The Metabolic Effects of Different Weight Loss Diets

Dietary Glycemic Index, Brain Function and Food Intake in Patients With Type 1 Diabetes Mellitus

Effect of Changing Diet on Fasting and Post Fat Load Lipoproteins

Ketogenic Diet Following Moderate to Severe Pediatric Traumatic Brain Injury

The Healthy Diet and Lifestyle Study II

Gut Kidney Axis in Enteric Hyperoxaluria

Framingham State Food Study

Effects of Low and Moderate Fat Diets on Lipids, Inflammation and Vascular Reactivity in the Metabolic Syndrome

Mediterranean-like Unprocessed (CLEAN-MED) Diet Intervention Study of the Gut Microbiome of Healthy Adults

Mindfulness Training to Promote Healthy Diet and Physical Activity in Teens

Therapeutic Diets in Alzheimer's Disease

Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL

Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling

Exercise Training and Metabolic Flexibility in Prediabetes