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ClinicalTrials.gov public records Last synced Nov 9, 2026, 12:28 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Monofocal Intraocular Lens Clear all

Conditions: Cataract
Interventions: Clareon Monofocal, Light-Adjustable Lens; Device
Lead sponsor: Gainesville Eye Associates; Other
Eligibility: 18 Years and older
Enrollment: 138 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Gainesville, Georgia

Conditions: Cataracts, Presbyopia
Interventions: SBL-3 multifocal intraocular lens, Control monofocal intraocular lens; Device
Lead sponsor: Lenstec Incorporated; Industry
Eligibility: 22 Years and older
Enrollment: 499 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 13
States / cities: Dothan, Alabama • Santa Maria, California • Cape Coral, Florida + 10 more

Conditions: Eye Disorders, Cataract Extraction, Cataract and IOL Surgery, Cataract Surgery Experience, Cataract Surgery, Intraocular Lens
Interventions: LLM-based Education; Other
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Cataract
Interventions: Clareon aspheric hydrophobic acrylic monofocal IOL; Device
Lead sponsor: Alcon Research; Industry
Eligibility: 22 Years and older
Enrollment: 376 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 16
States / cities: Fresno, California • Sacramento, California • San Leandro, California + 13 more

Conditions: Cataract
Interventions: Tecnis Multifocal Intraocular Lens, Monofocal Intraocular Lens; Device
Lead sponsor: Abbott Medical Optics; Industry
Eligibility: 18 Years and older
Enrollment: 445 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 17
States / cities: Tucson, Arizona • Rogers, Arkansas • Bakersfield, California + 14 more

Conditions: Cataract
Interventions: Clareon; Device
Lead sponsor: Gainesville Eye Associates; Other
Eligibility: 50 Years and older
Enrollment: 31 participants
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Gainesville, Georgia

Conditions: Cataract, Presbyopia
Interventions: Eyhance IOL; Device
Lead sponsor: Carolina Eyecare Physicians, LLC; Other
Eligibility: 50 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 2
States / cities: Sarasota, Florida • Mt. Pleasant, South Carolina

Conditions: Cataract
Interventions: Investigational Intraocular Lens Device #1: Next Generation TECNIS IOL, Control Monofocal Intraocular Lens: TECNIS Monofocal IOL; Device
Lead sponsor: Johnson & Johnson Surgical Vision, Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 247 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 10
States / cities: Torrance, California • Bradenton, Florida • Jacksonville, Florida + 6 more

Conditions: Presbyopia, Pseudophakia
Interventions: Brimonidine, pilocarpine; Drug
Lead sponsor: Massachusetts Eye and Ear Infirmary; Other
Eligibility: 60 Years and older
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Amplitude of Pseudoaccommodation
Interventions: Measurement of refractive error and amplitude of pseudoaccommodation; Device
Lead sponsor: Helm Vision Group; Other
Eligibility: 18 Years and older
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Valencia, California

Conditions: Aphakia, Postcataract
Interventions: KI-362-US1 (YP2.2VM); Device
Lead sponsor: Kowa Research Institute, Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 340 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 9
States / cities: Beverly Hills, California • Grand Junction, Colorado • Gainesville, Georgia + 5 more

Conditions: Cataract
Interventions: ACRYSOF® IQ Extended Depth of Focus IOL, ACRYSOF® IQ Monofocal IOL, Cataract surgery; Device · Procedure
Lead sponsor: Alcon Research; Industry
Eligibility: 22 Years and older
Enrollment: 242 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 11
States / cities: Birmingham, Alabama • Fort Collins, Colorado • Bradenton, Florida + 8 more

Conditions: Primary Open-Angle Glaucoma
Interventions: TECNIS PureSee Intraocular Lens, TECNIS ZCB00 Monofocal Intraocular Lens; Device
Lead sponsor: Mann Eye Institute; Other
Eligibility: 45 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cataract Surgery, Intraocular Lens Position, Refractive Outcomes After Cataract Surgery, Cataract
Interventions: Femtosecond Laser Capsulotomy - Small Size (4.6 mm), Femtosecond Laser Capsulotomy - Large Size (5.6 mm); Procedure
Lead sponsor: Twin Cities Eye Consultants; Other
Eligibility: 40 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Coon Rapids, Minnesota

Conditions: Cataracts
Interventions: ReSTOR; Device
Lead sponsor: Alcon Research; Industry
Eligibility: 18 Years and older
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2007
U.S. locations: 1
States / cities: Fort Worth, Texas

Conditions: Primary Open Angle Glaucoma
Interventions: Hydrus Aqueous Implant, Cataract surgery; Device · Procedure
Lead sponsor: Ivantis, Inc.; Industry
Eligibility: 45 Years and older
Enrollment: 1,143 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2020
U.S. locations: 26
States / cities: Phoenix, Arizona • Tucson, Arizona • Fayetteville, Arkansas + 23 more

Conditions: Cataract
Interventions: Standard Monofocal Intraocular Lens, Synchrony® Dual Optic Intraocular Lens; Device
Lead sponsor: Abbott Medical Optics; Industry
Eligibility: 50 Years and older
Enrollment: 410 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2013
U.S. locations: 20
States / cities: Laguna Hills, California • Los Alamitos, California • Los Altos, California + 17 more

Conditions: Cataract
Interventions: Acrysof Natural ReSTOR SN60D3, Acrysof Natural Monofocal SN60AT; Device
Lead sponsor: Alcon Research; Industry
Eligibility: 50 Years to 75 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Fort Worth, Texas

Conditions: Aphakia
Interventions: AcrySof single-piece IOL, AcrySof multi-piece IOL; Device
Lead sponsor: Alcon Research; Industry
Eligibility: Not listed
Enrollment: 138 participants
Timeline: 2023 – 2025
U.S. locations: 6
States / cities: Burbank, California • Jacksonville, Florida • Rock Island, Illinois + 3 more

Conditions: Cataract
Interventions: AcrySof IQ PanOptix Multifocal IOL, AcrySof Monofocal IOL; Device
Lead sponsor: Alcon Research; Industry
Eligibility: 22 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 12
States / cities: Fresno, California • Mt. Dora, Florida • Panama City, Florida + 9 more

Conditions: Cataract
Interventions: enVista MX60E, enVista MX60EF; Device
Lead sponsor: Bausch & Lomb Incorporated; Industry
Eligibility: 22 Years and older
Enrollment: 501 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 23
States / cities: Fayetteville, Arkansas • Garden Grove, California • Northridge, California + 19 more

Conditions: Cataract, Presbyopia
Interventions: IC-8 IOL Group, Control Group; Device
Lead sponsor: AcuFocus, Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 453 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 21
States / cities: Tucson, Arizona • Bakersfield, California • Laguna Hills, California + 18 more

Conditions: Patients Implanted With Monofocal Intraocular Lens
Interventions: Monofocal Intraocular Lenses; Device
Lead sponsor: Innovative Medical; Industry
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Williamsburg, Virginia

Conditions: Cataract, Glaucoma, Ocular Hypertension
Interventions: Bimatoprost Implant System, SpyGlass IOL, Timolol Maleate Ophthalmic Solution, 0.5%, Commercial IOL; Drug · Device
Lead sponsor: SpyGlass Pharma, Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2031
U.S. locations: 1
States / cities: Houston, Texas

Search by objective public record fields.

Comparison of Visual Outcomes With Mini-Monovision Between a Monofocal and an Adjustable Intraocular Lens

Clinical Evaluation of the Lenstec SBL-3 Multifocal Intraocular Lens

Effectiveness of a Large Language Model-Based Educational Tool on Intraocular Lens Options

Clinical Investigation of the Clareon® Intraocular Lens (IOL)

Clinical Investigation of Expanded Designs of a Multifocal IOL

Evaluation of Binocular Visual Acuity and Refractive Stability in the Alcon Clareon Intraocular Lens

Monofocal IOL Visual Outcomes When Targeting Mini Monovision

Clinical Investigation of the Next Generation Intraocular Lens

Pilocarpine and Brimonidine in Patients With Monofocal Lenses

Pseudoaccommodation of the Light Adjustable Lens: A Comparitive Study

Trial to Investigate the Safety and Effectiveness of the KI-362-US1 (YP2.2VM) Intraocular Lens (IOL) in Adult Participants for Correction of Aphakia Following Cataract Extraction

A Clinical Study of the ACRYSOF® IQ Extended Depth of Focus Intraocular Lens (IOL)

PureSee EDOF Versus ZCB00 Monofocal IOLs in Mild-to-Moderate Glaucoma

The Effect of Capsulotomy Size on Effective Lens Position in Robotic Laser Cataract Surgery

Contralateral ReSTOR / Monofocal or Phakic Eye

Safety & Effectiveness Study of the Hydrus Microstent for Lowering IOP in Glaucoma Patients Undergoing Cataract Surgery (HORIZON)

A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the Synchrony Dual Optic Intraocular Lens in Patients Undergoing Cataract Extraction

Visual Function and Patient Satisfaction After Bilateral Implantation of AcrySof Natural ReSTOR (Model SN60D3) or AcrySof Natural Monofocal (Model SN60AT)

A Real-World Evidence (RWE) Long-Term Follow-Up Study to Assess Outcomes of Alcon Monofocal Intraocular Lenses

Clinical Investigation of AcrySof® IQ PanOptix™ IOL Model TFNT00

Evaluate the Safety and Effectiveness of the enVista® One-Piece Hydrophobic Acrylic Trifocal Intraocular Lens

Clinical Evaluation of a Small Aperture Extended Depth of Focus Intraocular Lens

Prospective Evaluation of Near and Intermediate Visual Outcomes With Monofocal Intraocular Lenses: The Mast Study

Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhine)