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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Completed Not applicable Interventional Accepts healthy volunteers

Ibuprofen Inhibits Human Sweet Taste

NCT06291337
View directory record Official record
Conditions
Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Ibuprofen Solution in Healthy Participants, Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Naproxen Solution in Healthy Participants
Interventions
Inhibition of Sweet Taste by Ibuprofen Oral Rinses, Inhibition of Sweet Taste by Naproxen Oral Rinses
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 70 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 3, 2024 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Not applicable Interventional Results available

Feasibility Study to Evaluate a New Energy Storage and Return Prosthetic Foot

NCT04239222
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Knee
Interventions
Revo-M, Taleo, Proflex XC
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
4
States / cities
Mesa, Arizona • Linthicum, Maryland • Dayton, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 22, 2024 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study of Experimental Models of Pain and Inflammation.

NCT01097902
View directory record Official record
Conditions
Pain, Inflammation
Interventions
Ibuprofen, Placebo tablet
Drug
Lead sponsor
Martin Angst
Other
Eligibility
18 Years to 60 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 18, 2013 · Synced Sep 7, 2026, 9:53 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

NSAID Use in Postpartum Hypertensive Women

NCT02902172
View directory record Official record
Conditions
Hypertension
Interventions
Acetaminophen, NSAID
Drug
Lead sponsor
St. Louis University
Other
Eligibility
14 Years to 50 Years · Female only
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 30, 2018 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Phase 2 Interventional Results available

Comparison of Ibuprofen, Cyclobenzaprine, or Both for Acute Cervical Strain: A Randomized Clinical Trial

NCT00790270
View directory record Official record
Conditions
Cervical Strain
Interventions
Cyclobenzaprine, Ibuprofen, Ibuprofen plus Cyclobenzaprine
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Nov 20, 2012 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Phase 4 Interventional

Caldolor Versus Caldolor Plus OFIRMEV in Total Knee or Hip Arthroplasty Surgeries

NCT01773005
View directory record Official record
Conditions
Pain
Interventions
Ofirmev, Caldolor
Drug
Lead sponsor
Anita Gupta
Other
Eligibility
18 Years to 70 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 28, 2016 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Phase 2 Interventional

Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial

NCT03978767
View directory record Official record
Conditions
Preeclampsia Severe, Preeclampsia Postpartum
Interventions
Ibuprofen 600 mg, Ketorolac, Acetaminophen, Oxycodone
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
Female only
Enrollment
287 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 7, 2026, 9:53 AM EDT
Recruiting Phase 4 Interventional

Safety of Short-course of NSAIDs in Pediatric Patients With CKD

NCT06860711
View directory record Official record
Conditions
Chronic Kidney Disease, Pediatric Urology
Interventions
NSAIDs, Placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Months to 25 Years
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Phase 3 Interventional Results available

Maxigesic IV Phase 3 Bunionectomy Study

NCT02689063
View directory record Official record
Conditions
Post Operative Pain
Interventions
Maxigesic IV, IV Acetaminophen, IV Ibuprofen, Placebo IV
Drug
Lead sponsor
AFT Pharmaceuticals, Ltd.
Industry
Eligibility
18 Years to 65 Years
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Pasadena, Maryland • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 5, 2021 · Synced Sep 7, 2026, 9:53 AM EDT
Not yet recruiting Phase 2 Interventional

Jaw Muscle Pain Post Wisdom Molar Surgery

NCT07094542
View directory record Official record
Conditions
Post Operative Pain, Impacted Third Molar Tooth, Muscle Pain
Interventions
Temporo-masseteric Nerve Block Injection, Oral Pain Medications only
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 7, 2026, 9:53 AM EDT
Terminated Phase 2Phase 3 Interventional Results available

Paracetamol With Caffeine to Treat Episodic Tension Type Headache

NCT01755702
View directory record Official record
Conditions
Headache, Tension-Type
Interventions
Placebo, Experimental paracetamol + caffeine formulation, ibuprofen marketed formulation, Paracetamol marketed formulation
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
7
States / cities
Pembroke Pines, Florida • Springfield, Massachusetts • Wellesley Hills, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2015 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Self Selection Trial of Naproxen Sodium

NCT01383486
View directory record Official record
Conditions
Pain
Interventions
Naproxen sodium ER (BAYH6689), Advil
Drug
Lead sponsor
Bayer
Industry
Eligibility
12 Years and older
Enrollment
253 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
10
States / cities
Anaheim, California • Yorba Linda, California • Pembroke Pines, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2015 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Phase 4 Interventional Results available

Hydrocodone Compared to Acetaminophen and Ibuprofen for Post-nail Procedure Analgesia

NCT05544734
View directory record Official record
Conditions
Nail Diseases, Nail Abnormality
Interventions
Hydrocodone 5Mg/Acetaminophen 325Mg Tab, Acetaminophen 1000mg, Ibuprofen 400 mg
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 95 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Phase 4 Interventional

Use of ThermaCare Heat Wraps and Ibuprofen as an Adjunct to Physical Therapy for Neck Pain

NCT02327338
View directory record Official record
Conditions
Heat, Pain
Interventions
thermacare heat wraps, Ibuprofen
Device · Drug
Lead sponsor
Future Sciene Technology
Industry
Eligibility
18 Years to 80 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Henderson, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 31, 2017 · Synced Sep 7, 2026, 9:53 AM EDT
Terminated Phase 4 Interventional Results available

NSAIDs vs Opioids for Post-op Pain in Supracondylar Humerus Fractures

NCT04905563
View directory record Official record
Conditions
Supracondylar Humerus Fracture
Interventions
Acetaminophen-Hydrocodone, Acetaminophen and Ibuprofen
Drug
Lead sponsor
Le Bonheur Children's Hospital
Other
Eligibility
4 Years to 13 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Phase 3 Interventional Results available

Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study

NCT01229449
View directory record Official record
Conditions
Post-operative Pain
Interventions
Ibuprofen/acetaminophen, Ibuprofen/acetaminophen (higher dose), Nurofen Plus®, Panadeine® Extra, Placebo
Drug
Lead sponsor
Reckitt Benckiser LLC
Industry
Eligibility
16 Years and older
Enrollment
678 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2018 · Synced Sep 7, 2026, 9:53 AM EDT
Terminated Phase 4 Interventional Results available

Methadone and Medication Abortion

NCT04941443
View directory record Official record
Conditions
Pain, Medical Abortion
Interventions
Methadone Pill, Ibuprofen
Drug
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 22, 2023 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Phase 3 Interventional

Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy

NCT02330926
View directory record Official record
Conditions
Cachexia, Neoplasms
Interventions
standard care, nutritional supplements and advice, home-based self-assisted exercise program, Ibuprofen
Other · Dietary Supplement · Behavioral + 1 more
Lead sponsor
Norwegian University of Science and Technology
Other
Eligibility
18 Years and older
Enrollment
221 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Phase 3 Interventional Results available

Study of Post-Herniorrhaphy Non-opioid MMA Regimens

NCT03907176
View directory record Official record
Conditions
Analgesia
Interventions
HTX-011, Luer lock applicator, Ibuprofen, Acetaminophen
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
30
States / cities
Anaheim, California • La Mesa, California • Orange, California + 22 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Not applicable Interventional Results available

STandard Versus No Opioid Prescription After Prolapse and Anti-INcontinence Surgery Trial

NCT04491617
View directory record Official record
Conditions
Postoperative Pain, Opioid Use, Prolapse; Female, Incontinence
Interventions
Standard opioid prescribing, Restrictive opioid prescribing
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 23, 2025 · Synced Sep 7, 2026, 9:53 AM EDT
Terminated Phase 3 Interventional Results available

Management Of Pain After Cesarean Trial

NCT03929640
View directory record Official record
Conditions
Pain, Postoperative, Opioid Use
Interventions
Acetaminophen, Placebo, Ibuprofen
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 3, 2024 · Synced Sep 7, 2026, 9:53 AM EDT
Not yet recruiting Phase 3 Interventional

A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery

NCT07225140
View directory record Official record
Conditions
Post Operative Pain, Acute
Interventions
Combogesic® tablets, Acetaminophen 500mg, Placebo
Drug
Lead sponsor
AFT Pharmaceuticals, Ltd.
Industry
Eligibility
12 Years to 17 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 7, 2026, 9:53 AM EDT
Completed Phase 4 Interventional Results available

Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients

NCT02432456
View directory record Official record
Conditions
Wounds and Injuries, Rib Fractures
Interventions
Ketamine, Placebo, Intercostal Nerve Block, Acetaminophen, Ibuprofen, Pantoprazole, Methocarbamol, Opioid
Drug · Procedure
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 4, 2020 · Synced Sep 7, 2026, 9:53 AM EDT
Recruiting Phase 4 Interventional

The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair

NCT07076069
View directory record Official record
Conditions
Rotator Cuff Repairs, Pain Management
Interventions
Multimodal Pain Regimen, Standard of Care Pain Regimen
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 7, 2026, 9:53 AM EDT