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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:22 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 73–96 of 230 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: N Acetyl Cysteine Clear all

Conditions: Infantile Neronal Ceroid Lipofuscinosis
Interventions: Cystagon; Drug
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 6 Months to 3 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2013
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Covid19
Interventions: Famotidine, N-Acetyl cysteine; Drug
Lead sponsor: Prisma Health-Upstate; Other
Eligibility: 18 Years and older
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 3
States / cities: Easley, South Carolina • Greenville, South Carolina • Greer, South Carolina

Conditions: Systemic Lupus Erythematosus
Interventions: N-acetylcysteine, Placebo; Drug
Lead sponsor: State University of New York - Upstate Medical University; Other
Eligibility: 18 Years and older
Enrollment: 290 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2028
U.S. locations: 12
States / cities: Los Angeles, California • New Haven, Connecticut • Atlanta, Georgia + 8 more

Conditions: Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
Interventions: Neutral pills with no medicinal effect, Inosine; Tocopherols, Tocotrienol, CoQ10 combination capsule; Niacinamide SR; Viatmin C; N-acetyl Cysteine; Complete Multivitamin with all minerals, Inosine; Tocopherol, Tocotrienol, CoQ10 combination capsule; Niacinamide; Vitamin C; N-acetyl Cysteine; Complete Multivitamin with all minerals; Minocycline; Drug · Dietary Supplement
Lead sponsor: Mid-Atlantic Retina Consultations, Inc.; Other
Eligibility: Not listed
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Osteoarthritis, Knee, Total Knee Arthroplasty, Chronic Postsurgical Pain
Interventions: GlyNAC (combination of glycine and n-acetylcysteine), Placebo; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 50 Years and older
Enrollment: 148 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Trichotillomania, Hair Pulling
Interventions: N-Acetylcysteine, Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 8 Years to 17 Years
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Autistic Disorder
Interventions: N-Acetyl Cysteine; Drug
Lead sponsor: Stanford University; Other
Eligibility: 3 Years to 12 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Stanford, California

Conditions: Contrast Induced Nephropathy
Interventions: N-acetylcysteine; Drug
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2014
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Hypertrophic Cardiomyopathy
Interventions: N-acetylcysteine, Placebo; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Schizophrenia
Interventions: N-Acetylcysteine, Placebo; Dietary Supplement · Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Diabetic Nephropathy, Proteinuria, Oxidative Stress
Interventions: N-acetylcysteine placebo and silibin placebo, N-acetylcysteine active and silibin placebo, N-acetylcysteine placebo and silibin active, N-acetylcysteine active and silibin active, N-acetylcysteine active + high-dose silibin active; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 76 Years
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Diabetes, Diabetic Retinopathy
Interventions: DVS supplementation; Dietary Supplement
Lead sponsor: ZeaVision, LLC; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 2
States / cities: Pomona, California • Tahlequah, Oklahoma

Conditions: Stage 0/1 Breast Cancer, Post Biopsy, Pre-surgery
Interventions: IV/oral n-acetylcysteine; Drug
Lead sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Chorioamnionitis, Brain Injury
Interventions: N-acetylcysteine, Control; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 13 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Healthy
Interventions: N-acetylcysteine, ascorbate, Placebo; Drug
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 49 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Interstitial Lung Disease, Connective Tissue Disease
Interventions: N-Acetylcysteine; Drug
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2011
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Alcoholism
Interventions: N-acetylcysteine, Placebo; Drug
Lead sponsor: Minneapolis Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Multiple Sclerosis
Interventions: Progressive exercise, Neuromuscular electrical stimulation delivered using the electrical therapy device EMPI 300 PV, Modified paleolithic diet, Omega 3 fatty acids, Full Spectrum vitamin, Essential - hydroxytyrosol, Maltodextrin fiber supplement, Mineral boost (magnesium), Niacinamide, Methyl B12, Taurine, creatine, thiamine, riboflavin, N acetylcysteine, alpha lipoic acid, L acetyl carnitine, methyl folate, coenzyme Q, meditation, self massage, learning, Coconut oil; Other · Device · Dietary Supplement + 1 more
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 65 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Traumatic Brain Injury
Interventions: N-Acetyl cysteine; Drug
Lead sponsor: HonorHealth Research Institute; Other
Eligibility: 60 Years to 100 Years
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Phoenix, Arizona

Conditions: Multiple Sclerosis
Interventions: N-acetyl Cysteine; Dietary Supplement
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Traumatic Brain Injury
Interventions: Multivitamin Supplement intervention; Dietary Supplement
Lead sponsor: Amen Clinics, Inc.; Industry
Eligibility: 18 Years and older · Male only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Newport Beach, California

Conditions: Chronic Bronchitis
Interventions: Guafenesin tablets; Drug
Lead sponsor: American Health Research; Other
Eligibility: 40 Years to 90 Years
Enrollment: 82 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 2
States / cities: Charlotte, North Carolina • Rock Hill, South Carolina

Conditions: Healthy
Interventions: OP-101; Drug
Lead sponsor: Orpheris, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Schizophrenic Psychoses
Interventions: n-acetylcysteine, Placebo; Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years to 35 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 2
States / cities: Boston, Massachusetts

Search by objective public record fields.

Cystagon to Treat Infantile Neuronal Ceroid Lipofuscinosis

Trial of Famotidine & N-Acetyl Cysteine for Outpatients With COVID-19

Treatment of Systemic Lupus Erythematosus (SLE) With N-acetylcysteine

Supplemental Adjuvants for Intracellular Nutrition and Treatment

Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

N-Acetylcysteine for Pediatric Trichotillomania

An Open-Label Study of N-Acetyl Cysteine in Children With Autism

Safety Study Of N-Acetylcysteine For Prevention Of Contrast Induced Nephropathy In Patients w/Stage 3 Renal Failure

Hypertrophic Regression With N-Acetylcysteine in HCM

A Pilot Trial of Acute N-Acetylcysteine Effects on Working Memory and Other Cognitive Functions in Schizophrenia

N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy

Diabetic Retinopathy Functional Evaluation Study: Monitoring Carotenoid Vitamins Treatment Using ERG

Pilot Study of Anti-oxidant Supplementation With N-Acetyl Cysteine in Stage 0/I Breast Cancer

Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio)

Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans

A Clinical Trial for CTD-ILD Treatment

N-acetylcysteine in Alcohol Dependence

Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)

Prospective Analysis of the Use of N-Acetylcysteine and Vitamins in the Treatment of TBI in Geriatric Patients

Physiological Effects of N-Acetyl Cysteine in Patients With Multiple Sclerosis

Single Photon Emission Computed Tomography (SPECT) Imaging Study of Professional American Football Players

A Study to Explore if Long-term Use of Mucinex Can Help With Symptoms in Patients With Stable Chronic Bronchitis.

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of OP-101 After Intravenous Administration in Healthy Volunteers

N-Acetyl-Cysteine (NAC) in Early Phase Schizophrenia Spectrum Psychosis