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ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:22 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–120 of 230 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: N Acetyl Cysteine Clear all

Conditions: Post Traumatic Stress Disorder (PTSD), Addiction, Alcohol Abuse
Interventions: N-Acetylcysteine (NAC) Treatment, Cognitive Behavioral Therapy (CBT), Inactive Placebo Oral Capsule, Functional magnetic resonance imaging (fMRI), Proton magnetic resonance spectroscopy (MRS) Imaging; Drug · Behavioral · Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 70 Years
Enrollment: 182 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2022
U.S. locations: 2
States / cities: Charleston, South Carolina

Conditions: Kidney Failure
Interventions: N-Acetylcysteine; Drug
Lead sponsor: Minneapolis Veterans Affairs Medical Center; Federal
Eligibility: 18 Years and older
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Parkinson Disease, Cerebrospinal Fluid
Interventions: N-Acetylcysteine, Lumbar Puncture, Fluoroscopy; Drug · Procedure · Radiation
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Parkinson's Disease, Gaucher's Disease
Interventions: N-acetylcysteine; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Nicotine Dependence
Interventions: N-acetylcysteine, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cocaine Use Disorder, Opioid Use Disorder, Stimulant Use Disorder
Interventions: n-acetylcysteine, Hydromorphone, Placebo n-acetylcystine, Placebo hydromorphone; Drug
Lead sponsor: William Stoops; Other
Eligibility: 18 Years to 55 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 2
States / cities: Lexington, Kentucky

Conditions: Fuchs Endothelial Corneal Dystrophy
Interventions: N-acetyl cysteine (NAC) 10% solution, N-acetyl cysteine (NAC) 20% solution, Visine Dry Eye Relief eye drops; Drug
Lead sponsor: Massachusetts Eye and Ear Infirmary; Other
Eligibility: 21 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Type 2 Diabetes, Oxidative Stress
Interventions: N-acetylcysteine; Drug
Lead sponsor: Utzschneider, Kristina, M.D.; Individual
Eligibility: 18 Years to 75 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Focus is Determination of the Role of SNO-Hb in Forearm Blood Flow Regulation
Interventions: Oral N-acetylcysteine; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 40 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Mitochondrial Disease
Interventions: N-Acetylcysteine; Drug
Lead sponsor: Michio Hirano, MD; Other
Eligibility: 18 Years to 80 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Schizophrenia
Interventions: N-acetylcysteine (NAC), Inactive placebo capsule; Drug
Lead sponsor: VA Greater Los Angeles Healthcare System; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Bulimia Nervosa
Interventions: N-acetylcysteine; Drug
Lead sponsor: Lindner Center of HOPE; Other
Eligibility: 18 Years to 65 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Mason, Ohio

Conditions: Depression
Interventions: N-acetyl cysteine; Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 15 Years to 24 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Parkinson Disease
Interventions: N-acetylcysteine capsule; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Alcohol Use Disorder, Bipolar Disorder
Interventions: N-Acetylcysteine, Gabapentin, Placebo Oral Tablet; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Chronic Pain
Interventions: Inflammation Support Formula, Nerve Health Formula, Redox Support Formula; Dietary Supplement
Lead sponsor: Ethos Research & Development; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Newport, Kentucky

Conditions: Effects of High Altitude, Hypoxia, Inadequate or Impaired Breathing Pattern or Ventilation, Abnormal Blood Oxygen Pressure
Interventions: NAC, Placebo; Drug
Lead sponsor: United States Army Research Institute of Environmental Medicine; Federal
Eligibility: 18 Years to 39 Years
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Natick, Massachusetts

Conditions: Amyotrophic Lateral Sclerosis
Interventions: PolyMVA; Drug
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: Not listed
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Endodontic Disease
Interventions: N acetyl cysteine; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 6 Years to 18 Years
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Prevention of Hangover Using N-Acety Cysteine
Interventions: N-acetyl cysteine, placebo; Dietary Supplement · Other
Lead sponsor: St. Luke's Hospital and Health Network, Pennsylvania; Other
Eligibility: 21 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Bethlehem, Pennsylvania

Conditions: Type 2 Diabetes
Interventions: Placebo, n-aceylcysteine; Drug
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Mild Cognitive Impairment
Interventions: Memory XL, placebo; Drug
Lead sponsor: University of Oklahoma; Other
Eligibility: 55 Years to 85 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 2
States / cities: Oklahoma City, Oklahoma

Conditions: COVID-19
Interventions: NAC (N-acetyl cysteine), Alpha lipoic acid (ALA), liposomal glutathione (GSH); Drug
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Orange, California

Conditions: Lymphoma
Interventions: N-Acetylcysteine; Drug
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 7
States / cities: Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more

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Clinical Trial for Alcohol Use Disorder and Post Traumatic Stress Disorder (PTSD)

Acetylcysteine in the Prevention of Renal Failure After Bypass Surgery

Does N-Acetylcysteine Decrease Spontaneous Oxidation of Central Neural Dopamine in Parkinson's Disease?

Intravenous N-acetylcysteine for the Treatment of Gaucher's Disease and Parkinson's Disease

N-Acetylcysteine and Smoking Reduction

Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)

Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy

Effect of the Anti-oxidant N-acetylcysteine on Beta-cell Function in Type 2 Diabetes

The Role of S-nitrosohemoglobin in Regulating Systemic Blood Flow During Hypoxia and Normoxia

Study of N-acetylcysteine in the Treatment of Patients With the m.3243A>G Mutation and Low Brain Glutathione Levels

N-acetylcysteine (NAC) for Improving Cognitive Dysfunction in Schizophrenia

N-acetylcysteine in the Treatment of Bulimia Nervosa

N-acetylcysteine in the Treatment of Depressive Symptoms in Bipolar Offspring

Repeated-Dose Oral N-acetylcysteine for the Treatment of Parkinson's Disease

Imaging GABAergic/Glutamatergic Drugs in Bipolar Alcoholics Alcoholics

Pilot Study: Impact of Biomarker-Guided Dietary Supplementation on Quality-of-Life Measures in Subjects With Chronic Pain

Induced Changes in Ventilatory Responsiveness and Altitude Exposure

Open Label Study: Treatment of ALS Fatigue With PolyMVA

N-Acetyl Cysteine Protects Pulpal Stem Cells in Endodontic Revascularization

Use of NAC in Prevention of Hangover Symptoms; Independent Alcohol Consumption Protocol

Antioxidant Treatment of Type 2 Diabetes

MemoryXL Effects on Mild Cognitive Impairment Patients

The Role of Glutathione Deficiency and MSIDS Variables in Long COVID-19

A Study of N-Acetylcysteine (N-AC) in People Receiving CAR T-cell Therapy for Lymphoma