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ClinicalTrials.gov public records Last synced Nov 14, 2026, 6:05 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 249 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: N-acetyl-l-cysteine Clear all

Conditions: Autistic Disorder, Seizures, Irritability
Interventions: N-Acetyl Cysteine (NAC); Drug
Lead sponsor: Nationwide Children's Hospital; Other
Eligibility: 6 Years to 21 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Mild Depression
Interventions: N-acetylcysteine, Mindfulness-based cognitive therapy, Placebo, Sham mindfulness-based intervention; Drug · Behavioral
Lead sponsor: University of Cincinnati; Other
Eligibility: 15 Years to 24 Years
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Autistic Disorder
Interventions: N-Acetyl Cysteine, Placebo - sugar pill; Drug · Other
Lead sponsor: Stanford University; Other
Eligibility: 3 Years to 12 Years
Enrollment: 43 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Stanford, California

Conditions: Nicotine Dependence, Smoking
Interventions: N-acetylcysteine (NAC), Placebo; Drug · Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 114 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Asthma
Interventions: N-acetylcysteine; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 80 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Interventions: NAC 900mg/day, NAC 3600mg/day, NAC 0mg/day (Placebo); Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 21 Years to 60 Years
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Self-Harm, Depression, Suicide
Interventions: N-acetyl cysteine, Placebo oral tablet; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 16 Years to 24 Years · Female only
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Acute Respiratory Infection
Interventions: Mucinex, Placebo; Drug
Lead sponsor: Reckitt Benckiser LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Transposition of Great Vessels, Congenital Heart Disease
Interventions: N-acetylcysteine, Placebo; Drug
Lead sponsor: University of Michigan; Other
Eligibility: Up to 3 Months
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Primary Open Angle Glaucoma
Interventions: GlaucoCetin, Placebo; Dietary Supplement · Other
Lead sponsor: Wills Eye; Other
Eligibility: 40 Years to 80 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Aging, Erythrocyte Glutathione Deficiency, Muscle Weakness
Interventions: Cysteine (as n-acetylcysteine) and Glycine; Dietary Supplement
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 21 Years to 80 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Fibromyalgia
Interventions: amino acid-based blend; Dietary Supplement
Lead sponsor: Pekarovics, Susan, MD; Other
Eligibility: 18 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use
Interventions: Medical Management Counseling, N-acetylcysteine, Placebo; Behavioral · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Borderline Personality Disorder, Self-Injurious Behavior
Interventions: N-Acetylcysteine, placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Autism, Severe Behavior Disorder
Interventions: placebo, glutathione, glutathione, vit C and NAC; Drug
Lead sponsor: University of Louisville; Other
Eligibility: 5 Years to 16 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Louisville, Kentucky

Conditions: Open-angle Glaucoma, Diabetic Retinopathy
Interventions: GlaucoHealth, GlaucoSelect, Placebo; Drug
Lead sponsor: The New York Eye & Ear Infirmary; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Cannabis Use Disorder
Interventions: N-acetyl cysteine, Placebo oral capsule; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 14 Years to 21 Years
Enrollment: 192 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Sickle Cell Disease, Sickle Cell Anemia
Interventions: N-Acetylcysteine; Drug
Lead sponsor: Bloodworks; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2020
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Niemann-Pick Disease, Type C
Interventions: N-Acetyl Cysteine; Drug
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 12 Months and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Neuroectodermal Tumors, Primitive, Liver Neoplasms, Osteosarcoma, Other Childhood Cancers Using Cisplatin-based Regimens
Interventions: N-Acetylcysteine; Drug
Lead sponsor: Children's Hospital Los Angeles; Other
Eligibility: 1 Year to 21 Years
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Filamentary Keratitis
Interventions: Mucinex®; Drug
Lead sponsor: Massachusetts Eye and Ear Infirmary; Other
Eligibility: 18 Years to 80 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Hermansky-Pudlak Syndrome (HPS), Pulmonary Fibrosis, Oculocutaneous Albinism, Platelet Storage Pool Deficiency, Metabolic Disease
Interventions: Losartan, Zileuton, N-Acetylcysteine, Pravastatin, Erythromycin; Drug
Lead sponsor: National Human Genome Research Institute (NHGRI); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Hysterectomy
Interventions: IV N-acetylcysteine, IV Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: NAC
Interventions: N-acetylcysteine NAC; Drug
Lead sponsor: Lindner Center of HOPE; Other
Eligibility: 18 Years to 65 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Mason, Ohio

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Treatment Resistant Epilepsy and N-Acetyl Cysteine

Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth

A Study of N-Acetyl Cysteine in Children With Autism

N-acetylcysteine for Tobacco Use Disorder

Inpatient Clinical Trial of NAC

Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents

Evaluating the Effect of Mucinex 1200mg on Mucociliary and Cough Clearance During an Acute Respiratory Infection

N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study)

Vision Preservation and Restoration Following a 6 Month Trial of GlaucoCetin

Energetics and Function in Older Humans

Effect of an Amino-Acid-Based Blend on Human Growth Hormone (hGH) and Fibromyalgia (FM) Symptoms

N-acetylcysteine Treatment of Alcohol Use Disorder In Veterans With TBI

N-Acetylcysteine in Adjunct to DBT for the Treatment of Self-Injurious Behavior in BPD

Study of Glutathione, Vitamin C and Cysteine in Children With Autism and Severe Behavior Problems

Safety and Efficacy of Anti-Oxidants and Anti-inflammatory Agents in Glaucoma and Diabetic Retinopathy

N-Acetylcysteine for Youth Cannabis Use Disorder

A Pilot Study of N-acetylcysteine in Patients With Sickle Cell Disease

Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine

NAC to Prevent Cisplatin-induced Hearing Loss

Mucinex® for Treatment of Filamentary Keratitis

Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome

NAC vs Placebo on Opioid Use for Hysterectomy

N-acetylcysteine in Bulimia Nervosa