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ClinicalTrials.gov public records Last synced Oct 17, 2026, 6:07 AM EDT

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Showing 1–24 of 26 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: N-of-1 trials Clear all
Completed Early Phase 1 Interventional

N-of-1 Trials for Blood Pressure Medications in Adults

NCT02744456
View directory record Official record
Conditions
Hypertension, High Blood Pressure
Interventions
Losartan, Amlodipine, Hydrochlorothiazide
Drug
Lead sponsor
Columbia University
Other
Eligibility
21 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 26, 2019 · Synced Oct 17, 2026, 6:07 AM EDT
Recruiting Not applicable Interventional

Testing Drug Efficacy in Cystic Fibrosis Through N-of-1 Trials

NCT04580368
View directory record Official record
Conditions
Cystic Fibrosis
Interventions
CFTR Modulators
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
6 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2030
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 17, 2026, 6:07 AM EDT
Terminated Phase 2 Interventional Results available

Individualizing Anti-Inflammatory Medications for Adults With Axial Spondyloarthritis: A Series of N-of 1 Trials

NCT04115098
View directory record Official record
Conditions
Axial Spondyloarthritis
Interventions
Celecoxib, Naproxen, Meloxicam
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Phase 4 Interventional

N-of-1 for Beta-Blockers in Cardiac Amyloidosis

NCT05019027
View directory record Official record
Conditions
Cardiac Amyloidosis, Heart Diseases, TTR Cardiac Amyloidosis
Interventions
Beta blocker
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
65 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Personalized Trials for Stress Management Against Standard of Care

NCT05408832
View directory record Official record
Conditions
Stress
Interventions
Personalized Trial ABCCBA, Personalized Trial CBAABC, Stress Management Techniques with No Randomization Sequence (or order)
Behavioral
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
212 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Phase 4 Interventional Results available

Impact of Beta-blockers on Physical Function in HFpEF

NCT04767061
View directory record Official record
Conditions
Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure, Heart Disease
Interventions
Beta blockers
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
65 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 8, 2023 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Feasibility of Light Therapy for Fatigue N-of-1 Trials

NCT04707846
View directory record Official record
Conditions
Fatigue
Interventions
Bright Blue Light Commercial AYO Light Therapy Device, Dim Blue Light Commercial AYO Light Therapy Device
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 59 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Not applicable Interventional Results available

Assessing the Feasibility of N-of-1 Trials in Children With Hypertension and Chronic Kidney Disease

NCT04591171
View directory record Official record
Conditions
Hypertension, Chronic Kidney Diseases
Interventions
n-of-1 trial guided clinical decision making
Procedure
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
5 Years to 22 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 20, 2023 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Phase 4 Interventional Results available

Deprescribing Tamsulosin in Older Men

NCT05415748
View directory record Official record
Conditions
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
Interventions
Tamsulosin, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
55 Years to 80 Years · Male only
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 22, 2025 · Synced Oct 17, 2026, 6:07 AM EDT
Recruiting Not applicable Interventional

Personalized Exercise Recommendations for Chronic Pelvic Pain Using Reinforcement Learning

NCT07810218
View directory record Official record
Conditions
Pelvic Pain, Endometriosis, Chronic Pelvic Pain
Interventions
Reinforcement Learning (RL)-Based Personalized Exercise Recommendations, Generic Exercise Recommendation
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 17, 2026, 6:07 AM EDT
Not listed Not applicable Interventional

Additional Dietary Large Neutral Amino Acids (LNAA) for Improved Symptoms in Adult Classical Phenylktonuria (PKU)

NCT05174559
View directory record Official record
Conditions
Phenylketonurias
Interventions
PreKUnil® LNAA Medical Food for PKU
Other
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 4, 2023 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Not applicable Interventional

Hypertensive Ambulatory Trial to Compare the Efficacy of HCTZ and Lisinopril

NCT01258764
View directory record Official record
Conditions
Hypertension, Grade 1, Hypertension Treatment, N of 1 Study Design, Hypertension
Interventions
Lisinopril, Hydrochlorothiazide
Drug
Lead sponsor
Scripps Translational Science Institute
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated May 20, 2015 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Not applicable Interventional Results available

Individualized Studies of Triggers of Paroxysmal Atrial Fibrillation

NCT03323099
View directory record Official record
Conditions
Atrial Fibrillation Paroxysmal
Interventions
N-of-1, Data Tracking
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
499 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 8, 2023 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Not applicable Interventional

Pilot Comparison of N-of-1 Trials of Light Therapy

NCT03167372
View directory record Official record
Conditions
Cancer, Health Behavior, Depression
Interventions
Litebook® Advantage, Fitbit Flex2 TM
Other
Lead sponsor
Columbia University
Other
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 25, 2019 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Feasibility Study of Personalized Trials to Improve Sleep Quality

NCT05349188
View directory record Official record
Conditions
Sleep Disturbance
Interventions
Melatonin 3 mg, Melatonin 0.5 mg, Cellulose placebo pill
Dietary Supplement · Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Phase 4 Interventional

Combining N-of-1 Trials to Assess Fibromyalgia Treatments

NCT00000428
View directory record Official record
Conditions
Fibromyalgia
Interventions
Amitriptyline, Amitriptyline plus Fluoxitine
Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2004
U.S. locations
7
States / cities
Brockton, Massachusetts • Fall River, Massachusetts • Framingham, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2013 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Phase 4 Interventional Results available

Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF

NCT04757584
View directory record Official record
Conditions
Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure, Heart Disease
Interventions
Beta blockers
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
65 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 9, 2024 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Phase 4 Interventional Results available

N-of-1 Trials In Children With Hypertension

NCT03461003
View directory record Official record
Conditions
Pediatric Hypertension
Interventions
NICHE method, Usual care, Amlodipine, Lisinopril, Hydrochlorothiazide, Losartan
Other · Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
10 Years to 22 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 9, 2022 · Synced Oct 17, 2026, 6:07 AM EDT
Enrolling by invitation Phase 4 Interventional

Pilot Study of StudyU for N-of-1 Trials in HFrEF Patients (N-of-1 App)

NCT07252310
View directory record Official record
Conditions
HFrEF - Heart Failure With Reduced Ejection Fraction, Heart Failure, Heart Failure, Systolic, Heart Diseases
Interventions
beta blockers, StudyU Application
Drug · Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
65 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 17, 2026, 6:07 AM EDT
Active, not recruiting Not applicable Interventional

Exercise Therapy for PAD Using Mobile Health

NCT04889105
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
Smart MOVE!, General walking advice, Performance evaluation
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
40 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Not applicable Interventional Results available

Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension

NCT02412761
View directory record Official record
Conditions
Essential Hypertension
Interventions
Lisinopril, Amlodipine, Hydrochlorothiazide
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
9 Years to 22 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 15, 2018 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Not applicable Interventional Results available

N-of-1 Trials Using mHealth in Chronic Pain

NCT02116621
View directory record Official record
Conditions
Musculoskeletal Pain, Chronic Pain
Interventions
Trialist Intervention, smartphone
Behavioral · Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 75 Years
Enrollment
215 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Mather, California • Sacramento, California
Source: ClinicalTrials.gov public record
Updated May 25, 2018 · Synced Oct 17, 2026, 6:07 AM EDT
Enrolling by invitation Not applicable Interventional

N-of-1 Trial to Promote Beta-Blocker Titration in Heart Failure

NCT07489352
View directory record Official record
Conditions
Heart Failure, Beta-blocker, Older Adults
Interventions
N-of-1 trials, Enhanced usual care
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 17, 2026, 6:07 AM EDT
Completed Not applicable Interventional

Personalized Trial for Chronic Lower Back Pain

NCT04203888
View directory record Official record
Conditions
Back Pain Lower Back Chronic
Interventions
Swedish Massage, Yoga
Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Oct 17, 2026, 6:07 AM EDT