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Conditions: Progressive Supranuclear Palsy Richardson Syndrome (PSP-RS)
Interventions: NIO752, Placebo; Other · Drug
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 41 Years to 81 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 5
States / cities: Scottsdale, Arizona • San Francisco, California • Englewood, Colorado + 2 more

Conditions: Progressive Supranuclear Palsy (PSP)
Interventions: antisense oligonucleotide, placebo; Drug
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 40 Years to 75 Years
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 3
States / cities: La Jolla, California • Rochester, Minnesota • Nashville, Tennessee

Conditions: Alzheimer Disease, Autosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 1 (Disorder), Autosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 2 (Disorder), Autosomal Dominant Alzheimer Disease Due to Mutation of Amyloid Precursor Protein (Disorder)
Interventions: NIO752, Placebo; Drug · Other
Lead sponsor: University College, London; Other
Eligibility: 21 Years to 80 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: St Louis, Missouri

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