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ClinicalTrials.gov public records Last synced Oct 20, 2026, 5:37 AM EDT

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Showing 1–4 of 4 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: NSI-189 Clear all
Not listed No phase listed Observational

A Longitudinal Observational Cohort Study of NSI-189, With Out-Patients With Major Depressive Disorder

NCT02724735
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
NSI-189
Drug
Lead sponsor
Neuralstem Inc.
Industry
Eligibility
18 Years to 61 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
12
States / cities
Garden Grove, California • National City, California • Denver, Colorado + 9 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2016 · Synced Oct 20, 2026, 5:37 AM EDT
Not listed Phase 2 Interventional

Study of NSI-189 for Major Depressive Disorder

NCT02695472
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
80 Milligrams NSI-189, Placebo, 40 Milligrams NSI-189
Drug
Lead sponsor
Neuralstem Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
13
States / cities
Garden Grove, California • National City, California • Denver, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2017 · Synced Oct 20, 2026, 5:37 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Single-Dose Pharmacokinetics (PK) Study of Novel Neurogenic Compound NSI-189

NCT01310881
View directory record Official record
Conditions
Depression
Interventions
NSI-189 Phosphate
Drug
Lead sponsor
Neuralstem Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Glendale, California
Source: ClinicalTrials.gov public record
Updated Nov 21, 2011 · Synced Oct 20, 2026, 5:37 AM EDT
Completed Phase 1 Interventional

Multiple-Dose Pharmacokinetics (PK), and Pharmacodynamic (PD) Effect of NSI-189 Phosphate in Depression Patient Subjects

NCT01520649
View directory record Official record
Conditions
Depression
Interventions
NSI-189 Phosphate, microcrystalline cellulose capsules
Drug
Lead sponsor
Neuralstem Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Glendale, California
Source: ClinicalTrials.gov public record
Updated Apr 2, 2014 · Synced Oct 20, 2026, 5:37 AM EDT