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Showing 1–24 of 41 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Nasal CO2 Clear all
Withdrawn Not applicable Interventional

Oscillatory Versus Non-oscillatory Nasal Continuous Airway Pressure Neonatal Respiratory Support

NCT03711565
View directory record Official record
Conditions
Neonatal Respiratory Distress Related Conditions
Interventions
Regular Nasal CPAP using a conventional ventilator, High Frequency Nasal CPAP
Device
Lead sponsor
University of California, Davis
Other
Eligibility
Up to 4 Months
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Apr 5, 2021 · Synced Sep 10, 2026, 6:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessment of N-95 Facemask for Use in COVID-19 Pandemic in Case of Shortage of Personal Protective Equipment

NCT04416919
View directory record Official record
Conditions
Coronavirus Infection, Disease Prevention
Interventions
Assembled mask
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 10, 2026, 6:09 PM EDT
Completed No phase listed Interventional Results available

Companion Protocol for ¹³C-Methacetin Breath Tests in BMS: NCT03486899, NCT03486912 Referenced Trials

NCT03611101
View directory record Official record
Conditions
NASH - Nonalcoholic Steatohepatitis
Interventions
¹³C-Methacetin Breath Test, BMS-986036, BreathID MCS device
Combination Product · Drug · Device
Lead sponsor
Meridian Bioscience, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Humble, Texas
Source: ClinicalTrials.gov public record
Updated Dec 19, 2022 · Synced Sep 10, 2026, 6:09 PM EDT
Completed Phase 2 Interventional

Nasal Carbon Dioxide (CO2)for the Treatment of Temporomandibular Disorders (TMD)Related Pain

NCT00484029
View directory record Official record
Conditions
Temporomandibular Disorders, Pain, Headaches
Interventions
Nasal Carbon Dioxide, Air
Drug · Other
Lead sponsor
Capnia, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 19, 2010 · Synced Sep 10, 2026, 6:09 PM EDT
Completed Not applicable Interventional

Effect of CPAP on Fetal pH at Scheduled C-section in Morbidly Obese Women

NCT04993651
View directory record Official record
Conditions
Morbid Obesity, Cesarean Delivery Affecting Fetus
Interventions
CPAP
Device
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 10, 2026, 6:09 PM EDT
Completed Phase 3 Interventional Results available

Use of Methacetin Breath Test to Predict Liver Failure in Patients With Cirrhosis

NCT01157845
View directory record Official record
Conditions
Cirrhosis
Interventions
BreathID (Methacetin breath test)
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
3
States / cities
Detroit, Michigan • Charleston, South Carolina • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 15, 2014 · Synced Sep 10, 2026, 6:09 PM EDT
Suspended Early Phase 1 Interventional Accepts healthy volunteers

Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation

NCT05153395
View directory record Official record
Conditions
Healthy, Vasodilation, Insulin Resistance, Autonomic Dysfunction, Obesity
Interventions
Carbon dioxide breathing, Neurovascular Coupling, Human insulin
Other · Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 45 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 10, 2026, 6:09 PM EDT
Completed Phase 2 Interventional

The Effect of Nasal Carbon Dioxide (CO2) on Nasal Congestion in Subjects With Perennial Allergic Rhinitis

NCT00638755
View directory record Official record
Conditions
Perennial Allergic Rhinitis
Interventions
Nasal Carbon Dioxide
Drug
Lead sponsor
Capnia, Inc.
Industry
Eligibility
19 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 18, 2010 · Synced Sep 10, 2026, 6:09 PM EDT
Completed Phase 2Phase 3 Interventional Results available

13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF

NCT02786836
View directory record Official record
Conditions
Acute Liver Failure
Interventions
13C-Methacetin
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
11
States / cities
Birmingham, Alabama • San Francisco, California • New Haven, Connecticut + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2020 · Synced Sep 10, 2026, 6:09 PM EDT
Recruiting No phase listed Observational

The APS Phenotyping Study

NCT06521502
View directory record Official record
Conditions
ARDS, Sepsis, Pneumonia
Interventions
Blood collection, Urine Collection, Nasal, oral, and rectal swabs, Stool collection, Heat Moisture Exchange Filter collection, Tracheal Aspirate sample collection, Non-bronchoscopic bronchoalveolar lavage (NBBAL), Surveys, Short physical performance battery, Hand grip strength, CNS Vital Signs, Muscle Ultrasound, Muscle Strength, Spirometry, Lung Diffusion Testing (DLCO), Chest CT Scan
Other · Procedure · Radiation
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
20
States / cities
Fresno, California • Palo Alto, California • San Francisco, California + 12 more
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 10, 2026, 6:09 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Stroke and CPAP Outcome Study: A Sham-controlled Trial of CPAP Among Stroke Rehabilitation Patients

NCT02551757
View directory record Official record
Conditions
Stroke, Sleep Apnea, Obstructive
Interventions
Auto-titrating CPAP, Sham-CPAP
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 12, 2021 · Synced Sep 10, 2026, 6:09 PM EDT
Completed Phase 2 Interventional

The Effect of Nasal Carbon Dioxide (CO2) in the Symptomatic Treatment of Seasonal Allergic Rhinitis

NCT00917111
View directory record Official record
Conditions
Seasonal Allergic Rhinitis
Interventions
Nasal CO2, Inactive Placebo Gas
Drug
Lead sponsor
Capnia, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 14, 2012 · Synced Sep 10, 2026, 6:09 PM EDT
Completed Not applicable Interventional Results available

Physiological Changes With High-Flow Nasal Cannula

NCT03700606
View directory record Official record
Conditions
Respiratory Distress Syndrome in Premature Infant
Interventions
High flow nasal cannula, Nasal CPAP
Procedure
Lead sponsor
Sharp HealthCare
Other
Eligibility
23 Weeks to 28 Weeks
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 10, 2026, 6:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Exercise and Energy Balance on 24-hour Blood Glucose Control

NCT03350997
View directory record Official record
Conditions
Metabolic Disease, Adipose Tissue
Interventions
Trial 2 Exercise, Trial 1 Exercise
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 40 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 20, 2022 · Synced Sep 10, 2026, 6:09 PM EDT
Terminated Phase 2 Interventional Results available

Pilot Study Evaluating the Use of Nasal Carbon Dioxide for the Treatment of Cluster Headache

NCT02381795
View directory record Official record
Conditions
Cluster Headache
Interventions
Nasal Carbon Dioxide
Drug
Lead sponsor
Cady, Roger, M.D.
Individual
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 13, 2018 · Synced Sep 10, 2026, 6:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Cerebral Blood Flow and Childhood Obstructive Sleep Apnea

NCT02995837
View directory record Official record
Conditions
Obstructive Sleep Apnea Syndrome
Interventions
Sleep Study, Neurocognitive Testing, CBF During Wakefulness, CBF During Sleep
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
6 Years to 12 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 8, 2024 · Synced Sep 10, 2026, 6:09 PM EDT
Completed Phase 2 Interventional Results available

Market Potential of Carbon Dioxide Nasal Spray

NCT02113449
View directory record Official record
Conditions
Nasal Congestion
Interventions
Carbon Dioxide
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
4
States / cities
Chandler, Arizona • Pinellas Park, Florida • Paramus, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2015 · Synced Sep 10, 2026, 6:09 PM EDT
Active, not recruiting Not applicable Interventional

Stress Management Program

NCT06526585
View directory record Official record
Conditions
Stress, Anxiety
Interventions
Cyclic Sighing Breathing, Box Breathing, Hypnosis, Audiobook
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 10, 2026, 6:09 PM EDT
Terminated Not applicable Interventional

CPAP vs.Unsynchronized NIPPV at Equal Mean Airway Pressure

NCT03670732
View directory record Official record
Conditions
Prematurity, Respiratory Distress Syndrome, Apnea of Prematurity
Interventions
continuous positive airway pressure, nasal intermittent positive pressure ventilation
Other
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
Up to 6 Months
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Sep 10, 2026, 6:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Psychophysiological Effects of Controlled Respiration and Mindfulness

NCT05304000
View directory record Official record
Conditions
Stress, Physiological, Stress, Emotional, Insomnia
Interventions
Mindfulness Meditation, Cyclic Sighing Breathing, Box Breathing, Cyclic Hyperventilation with Retention
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
2
States / cities
Palo Alto, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Sep 10, 2026, 6:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Comparison of Pulse Oximetry, End-tidal Capnometry, and Integrated Pulmonary Index (IPI)

NCT01191528
View directory record Official record
Conditions
Postoperative Care
Interventions
capnostream 20, Oridian Medical 1987 ltd, Needham MA
Device
Lead sponsor
Allenmore Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Dec 12, 2010 · Synced Sep 10, 2026, 6:09 PM EDT
Terminated Phase 2 Interventional

The Effect of Nasal Carbon Dioxide in the Treatment of Moderate to Severe Migraine

NCT01253915
View directory record Official record
Conditions
Migraine
Interventions
Nasal Carbon Dioxide, Placebo
Drug
Lead sponsor
Capnia, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
3
States / cities
San Diego, California • Bethesda, Maryland • Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 30, 2013 · Synced Sep 10, 2026, 6:09 PM EDT
Completed Not applicable Interventional Results available

Intranasal CO2 for Allergic Rhinitis

NCT00618410
View directory record Official record
Conditions
Allergic Rhinitis
Interventions
Carbon dioxide, USP, Placebo
Device · Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 45 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 26, 2014 · Synced Sep 10, 2026, 6:09 PM EDT
Terminated Not applicable Interventional

Telemedicine for Improving Outcome in Inner City Patient Population With Hypercapneic Respiratory Failure

NCT03353064
View directory record Official record
Conditions
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome, Sleep Disordered Breathing, Neuromuscular Diseases
Interventions
Vivify, EMS
Other
Lead sponsor
Albert Einstein Healthcare Network
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 28, 2018 · Synced Sep 10, 2026, 6:09 PM EDT