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ClinicalTrials.gov public records Last synced Oct 9, 2026, 5:03 PM EDT

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Showing 169–192 of 216 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Near-Infrared Spectroscopy (NIRS) Clear all
Terminated Phase 1 Interventional

Cerebrovascular Reactivity in American Football Players

NCT03417492
View directory record Official record
Conditions
Traumatic Brain Injury, Mild Traumatic Brain Injury, Post-Concussion Syndrome
Interventions
Sildenafil Citrate
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
40 Years to 65 Years · Male only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 21, 2022 · Synced Oct 9, 2026, 5:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

MusculRA: The Effects of Rheumatoid Arthritis on Skeletal Muscle Biomechanics

NCT04226131
View directory record Official record
Conditions
Rheumatoid Arthritis, Healthy Controls
Interventions
Blood Draw, Disease Activity (DAS-28) Assessment, Skeletal Muscle Mitochondrial Respiratory Capacity, Muscle Biopsy, Body Composition, Cardiopulmonary Exercise Test (CPET), Strength Testing, Questionnaires, Skeletal Muscle Biomechanical Property Assessment
Other
Lead sponsor
Duke University
Other
Eligibility
25 Years to 75 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2023 · Synced Oct 9, 2026, 5:03 PM EDT
Not listed No phase listed Observational

Cerebral Oximetry and NIRS in Cardiac Arrest Patients

NCT03769740
View directory record Official record
Conditions
Cardiac Death, Cardiac Arrest, Emergencies
Interventions
Cerebral Oximetry
Device
Lead sponsor
Wayne State University
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
2
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 7, 2019 · Synced Oct 9, 2026, 5:03 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Ability of Near Infrared Spectroscopy to Isolate Compartments of the Extremity

NCT01283451
View directory record Official record
Conditions
Acute Compartment Syndrome
Interventions
Muscle contraction
Behavioral
Lead sponsor
J&M Shuler
Industry
Eligibility
18 Years to 75 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 15, 2018 · Synced Oct 9, 2026, 5:03 PM EDT
Completed No phase listed Observational

Exploring Near Infrared Spectroscopy (NIRS) Technologies for Assessment of Muscle Physiology, Tissue Oxygenation, and Blood Flow in Patients With Sickle Cell Disease (SCD)

NCT05604547
View directory record Official record
Conditions
SCD
Interventions
Non-Invasive Infrared Spectroscopy
Diagnostic Test
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years to 100 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 1, 2025 · Synced Oct 9, 2026, 5:03 PM EDT
Terminated Not applicable Interventional

Near Infrared Spectroscopy (NIRS) for Heart Failure Assessment.

NCT01577810
View directory record Official record
Conditions
Cardiac Failure
Interventions
Near Infrared Spectroscopy
Device
Lead sponsor
Phoenix Children's Hospital
Other
Eligibility
1 Day to 18 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Oct 9, 2026, 5:03 PM EDT
Completed Not applicable Interventional

NIRF Trial: Near-Infrared Spectroscopy for Intraoperative Restriction of Fluids Trial

NCT00731978
View directory record Official record
Conditions
Colorectal Surgery
Interventions
Restricted intraoperative fluid management
Procedure
Lead sponsor
Hutchinson Technology Inc
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
2
States / cities
Stanford, California • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 29, 2009 · Synced Oct 9, 2026, 5:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of Near Infrared Spectroscopy to Measure Intracranial ScvO2

NCT01746576
View directory record Official record
Conditions
Healthy
Interventions
Use of impedance threshold device during spontaneous ventilation
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 16, 2014 · Synced Oct 9, 2026, 5:03 PM EDT
Completed Not applicable Interventional Results available

Prospective Evaluation of Cognitive Outcomes After Anesthesia on Patients in the Beach Chair Position

NCT02674334
View directory record Official record
Conditions
Injury as a Result of Positioning
Interventions
NIRS, NIRS monitored not treated
Device
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 75 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 11, 2017 · Synced Oct 9, 2026, 5:03 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Functional Evaluation in Patients With Urea Cycle Disorders (UCD) During a Driving Task

NCT07701694
View directory record Official record
Conditions
Urea Cycle Disorder
Interventions
Not listed
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
16 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2032
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 9, 2026, 5:03 PM EDT
Terminated Not applicable Interventional Results available

The Vascular Biology of Dipyridamole in Peripheral Arterial Disease (PAD)

NCT00906035
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Dipyridamole 200mg and Aspirin 25mg bid:, Dipyridamole 200 mg bid, Aspirin 25 mg bid
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 79 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2010
U.S. locations
3
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 5, 2017 · Synced Oct 9, 2026, 5:03 PM EDT
Completed Not applicable Interventional Results available

Cardiac and Cerebral Hemodynamics With Umbilical Cord Milking Compared With Early Cord Clamping

NCT03621956
View directory record Official record
Conditions
Birth Asphyxia With Neurologic Involvement
Interventions
Umbilical Cord Milking, Early Cord Clamping
Procedure
Lead sponsor
Sharp HealthCare
Other
Eligibility
35 Weeks to 42 Weeks
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 8, 2024 · Synced Oct 9, 2026, 5:03 PM EDT
Not listed Phase 1Phase 2 Interventional

Prevention of Transfusion Related Acute Gut Injury (TRAGI) in Extremely Low Gestational Age Neonates (ELGANs) Using iNO

NCT02851472
View directory record Official record
Conditions
Anemia
Interventions
Inhaled Nitric Oxide, Placebo
Drug
Lead sponsor
New York Medical College
Other
Eligibility
2 Weeks and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
4
States / cities
Springfield, Massachusetts • Stony Brook, New York • Valhalla, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2019 · Synced Oct 9, 2026, 5:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

NIRS Guidance Trail in Children's Heart Surgery

NCT02157597
View directory record Official record
Conditions
Heart Defects, Congenital
Interventions
NIRS based management, Control
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
1 Day to 6 Months
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 12, 2016 · Synced Oct 9, 2026, 5:03 PM EDT
Completed No phase listed Observational

Intracoronary Imaging With NIRS-IVUS to Characterize Arterial Plaques

NCT01694368
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Not listed
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2021
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Oct 9, 2026, 5:03 PM EDT
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Broadband Near Infrared Spectroscopy to Understand the Role of Brain Cytochrome C Oxidase in Bipolar Disorder

NCT07806227
View directory record Official record
Conditions
Bipolar Disorder Depression
Interventions
Lurasidone (Latuda)
Drug
Lead sponsor
Martin Lan
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 9, 2026, 5:03 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

fNIRS for Disorders of Consciousness

NCT07485361
View directory record Official record
Conditions
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State, Unresponsive Wakefulness Syndrome, Brain Injury, TBI Traumatic Brain Injury
Interventions
Functional Near-Infrared Spectroscopy Monitoring
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 9, 2026, 5:03 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Near Infrared Spectroscopy in Children With Autism and ADHD

NCT01730079
View directory record Official record
Conditions
Attention Deficit Disorder With Hyperactivity, Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, Autism, Autism Spectrum Disorders
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
4 Years to 8 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 18, 2019 · Synced Oct 9, 2026, 5:03 PM EDT
Not listed Phase 4 Interventional

Early Caffeine in Preterm Neonates

NCT03086473
View directory record Official record
Conditions
BPD - Bronchopulmonary Dysplasia, Apnea of Prematurity, Hemodynamic Instability, Intubation
Interventions
Caffeine Citrate, Placebo (Normal Saline)
Drug
Lead sponsor
Jennifer Shepherd
Other
Eligibility
Up to 1 Day
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 3, 2021 · Synced Oct 9, 2026, 5:03 PM EDT
Withdrawn Not applicable Interventional

Non-invasive Near-infrared Spectroscopy (NIRS) Versus Invasive Licox Intracranial Pressure

NCT04247321
View directory record Official record
Conditions
Brain Injuries
Interventions
Licox® Brain Tissue Oxygen Monitoring System, Near-infrared spectroscopy (NIRS)
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Oct 9, 2026, 5:03 PM EDT
Completed Phase 1 Interventional

Assessment of Coronary Plaque Composition

NCT01581632
View directory record Official record
Conditions
Coronary Atherosclerosis, Endothelial Dysfunction, Coronary Small Vessel Disease
Interventions
LipiScan/LipiScan IVUS
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 5, 2019 · Synced Oct 9, 2026, 5:03 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Mechanisms of Muscle Blood Flow Dysregulation and Exercise Intolerance in Chronic Kidney Disease

NCT02664519
View directory record Official record
Conditions
Chronic Kidney Disease
Interventions
Forearm exercise training
Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Oct 9, 2026, 5:03 PM EDT
Completed No phase listed Observational

The Neu-Prem Trial: Neuromonitoring of Preterm Newborn Brain During Birth Resuscitation

NCT02605733
View directory record Official record
Conditions
Neurologic Manifestations, Premature Birth, Hypoxia-Ischemia, Brain
Interventions
EEG, NIRS
Device
Lead sponsor
Sharp HealthCare
Other
Eligibility
Up to 72 Hours
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Oct 9, 2026, 5:03 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Near-Infrared Spectroscopy for Blood Glucose Measurements

NCT01168115
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
InLight Solutions
Industry
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 22, 2010 · Synced Oct 9, 2026, 5:03 PM EDT