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Showing 1–24 of 66 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Negative pressure wound closure Clear all
Completed Not applicable Interventional Results available

Vacuum Assisted Closure as a Treatment for Open Fractures

NCT00582361
View directory record Official record
Conditions
Orthopaedic Traumatic Open Fractures
Interventions
Standard Wound Dressing, VAC
Procedure · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2010
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 13, 2013 · Synced Sep 11, 2026, 6:04 AM EDT
Completed Not applicable Interventional

SUpPress SSI - Single Use Negative Pressure Wound Therapy (NPWT) to Reduce Surgical Site Infections

NCT03816293
View directory record Official record
Conditions
Surgical Site Infection, Obesity, Diabetes, Cesarean Section Complications
Interventions
Negative Pressure Wound Therapy
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
3,680 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
5
States / cities
Atlanta, Georgia • Chicago, Illinois • Iowa City, Iowa + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 20, 2022 · Synced Sep 11, 2026, 6:04 AM EDT
Withdrawn Phase 4 Interventional

RCT to Compare Restrata and NPWT to Heal Complex DFUs

NCT04405050
View directory record Official record
Conditions
Diabetic Wound
Interventions
Restrata, Negative Pressure Wound Therapy (NPWT)
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2023 · Synced Sep 11, 2026, 6:04 AM EDT
Terminated Not applicable Interventional Results available

Prevention of Wound Complications After Cesarean Delivery in Obese Women Utilizing Negative Pressure Wound Therapy

NCT00654641
View directory record Official record
Conditions
Surgical Wound Dehiscence, Wound Infection
Interventions
Negative pressure wound closure, Standard wound closure
Procedure
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older · Female only
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
2
States / cities
Charleston, West Virginia • Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jan 29, 2013 · Synced Sep 11, 2026, 6:04 AM EDT
Withdrawn Not applicable Interventional

Incisional Wound Vac in Obese Patients

NCT00789659
View directory record Official record
Conditions
Wound Infection, Postoperative Complication
Interventions
Negative pressure dressing
Other
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Feb 9, 2017 · Synced Sep 11, 2026, 6:04 AM EDT
Completed Not applicable Interventional Results available

Negative Pressure Wound Therapy for Prevention of Poststernotomy Infection

NCT02020018
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
Prevena Incision Management System, Conventional sterile dry wound dressing
Device · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
1,869 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 5, 2019 · Synced Sep 11, 2026, 6:04 AM EDT
Terminated Phase 2Phase 3 Interventional Results available

The Effect of Nitroglycerin Ointment, Fluorescent Angiography, and Incisional Negative Pressure Wound Therapy on Mastectomy Skin Flap Perfusion-Related Problems

NCT03716050
View directory record Official record
Conditions
Perfusion; Complications
Interventions
Nitroglycerin, Negative Pressure Wound Therapy/ Wound VAC, Fluorescent Angiography with indocyanine-green (not to exceed 5mg/kg), No treatment
Drug · Device · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 20, 2020 · Synced Sep 11, 2026, 6:04 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Preventing Adverse Incisional Outcomes at Cesarean Multicenter Trial

NCT03009110
View directory record Official record
Conditions
Surgical Wound Infection, Cesarean Section
Interventions
Prophylactic NPWT, Standard Dressing
Device
Lead sponsor
Indiana University
Other
Eligibility
16 Years and older · Female only
Enrollment
1,624 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
6
States / cities
Birmingham, Alabama • Indianapolis, Indiana • New Orleans, Louisiana + 1 more
Source: ClinicalTrials.gov public record
Updated May 31, 2023 · Synced Sep 11, 2026, 6:04 AM EDT
Recruiting Phase 4 Interventional

Combined OFM and Vacuum-assisted Therapy for Expedited Regeneration Over Structures

NCT07385313
View directory record Official record
Conditions
Soft Tissue Defects, Soft Tissue Wounds, Traumatic Soft Tissue Defect
Interventions
Myriad™ applied in conjunction with NPWT, NPWT Alone
Device
Lead sponsor
Aroa Biosurgery Limited
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Aurora, Colorado • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 11, 2026, 6:04 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Incisional Negative Pressure Wound Therapy in High Risk Patients Undergoing Panniculectomy: A Prospective Randomized Controlled Trial

NCT03010137
View directory record Official record
Conditions
Complications Wounds, Negative Pressure Wound Therapy, Wound Healing Delayed, Incisional, Panniculectomy, Incisional Negative Pressure Wound Therapy, Incisional Vac, Wound Vac, Obese, Renal Failure, Kidney Transplant; Complications, Wound Healing Complication
Interventions
Incisional Negative Pressure Wound Therapy, Standard Closure with Skin Glue, PICO (Smith&Nephew), Dermabond
Procedure · Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2020 · Synced Sep 11, 2026, 6:04 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Do Single Use Negative Pressure Dressings Reduce Wound Complications in Obese Women After Cesarean Delivery

NCT02799667
View directory record Official record
Conditions
Obesity, Surgical Site Infections, Wound Complications, Complications; Cesarean Section
Interventions
Standard Dressing, Negative Pressure Wound Therapy Dressing
Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 20, 2021 · Synced Sep 11, 2026, 6:04 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Prevena Spine for Use in Spine Surgery

NCT05555355
View directory record Official record
Conditions
Surgery, Incision, Surgical
Interventions
Prevena Plus 125 Therapy Unit, Spine surgery
Device · Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Sep 11, 2026, 6:04 AM EDT
Completed Not applicable Interventional Results available

Evaluating Advantages of Prevena After Hip and Knee Arthroplasty

NCT01854138
View directory record Official record
Conditions
Infection of Total Hip Joint Prosthesis
Interventions
Prevena Incision Management System
Device
Lead sponsor
ProMedica Health System
Other
Eligibility
18 Years to 85 Years
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 11, 2018 · Synced Sep 11, 2026, 6:04 AM EDT
Completed Not applicable Interventional Results available

Comparison of Two Methods of Negative Pressure Wound Therapy

NCT00724750
View directory record Official record
Conditions
Acute Wounds From Trauma, Dehiscence or Surgical Complications
Interventions
Gauze suction (G-SUC), Vacuum Assisted Closure Device (VAC)
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 18, 2015 · Synced Sep 11, 2026, 6:04 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Vacuum Assisted Closure for Cesarean Section

NCT02390401
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
Vacuum-assisted closure, Standard sterile dressing
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
166 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
4
States / cities
Lebanon, New Hampshire • Nashua, New Hampshire
Source: ClinicalTrials.gov public record
Updated May 21, 2018 · Synced Sep 11, 2026, 6:04 AM EDT
Withdrawn Not applicable Interventional

VAC NPWT KCI Dressing Study

NCT01366105
View directory record Official record
Conditions
Surgical Wound Infection
Interventions
V.A.C. by K.C.I.
Device
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 3, 2013 · Synced Sep 11, 2026, 6:04 AM EDT
Terminated Not applicable Interventional Results available

The Use of the Prevena Incision Management System (PIMS) on Closed Incisions in Renal Transplant Subjects

NCT01341444
View directory record Official record
Conditions
Surgical Site Reaction
Interventions
Prevena Incision Management System, Standard of Care for Surgical Incisions
Device · Other
Lead sponsor
KCI USA, Inc
Industry
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Sep 11, 2026, 6:04 AM EDT
Completed Phase 4 Interventional Results available

Use of Negative Pressure Wound Therapy in High Risk Surgical Closed Incisions

NCT02137447
View directory record Official record
Conditions
High Risk Abdominal Wounds
Interventions
Negative Pressure treatment
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 95 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Sep 11, 2026, 6:04 AM EDT
Recruiting Phase 4 Interventional

NPWTi on Closure of Chronic Pressure Sores

NCT05598398
View directory record Official record
Conditions
Pressure Sore
Interventions
V.A.C.Ulta™ Negative Pressure Wound Therapy System, Standard of Care (Wet-to-dry dressings)
Device · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Sep 11, 2026, 6:04 AM EDT
Completed Not applicable Interventional Results available

The Use of the Prevena™ Incision Management System on Post-Surgical Cesarean Section Incisions

NCT01450631
View directory record Official record
Conditions
Post-operative Complications, Surgical Site Infection, Surgical Wound Infection
Interventions
Prevena™ Incision Management System (PIMS), Standard-of-care Dressing
Device
Lead sponsor
KCI USA, Inc
Industry
Eligibility
18 Years and older · Female only
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Sep 11, 2026, 6:04 AM EDT
Completed Phase 3 Interventional Results available

Antimicrobial Barrier Dressing Versus Closed-incision Negative Pressure Therapy in the Obese Primary Total Joint Arthroplasty

NCT03345771
View directory record Official record
Conditions
Osteoarthritis
Interventions
Antimicrobial Barrier Dressing, Negative Pressure Wound Therapy (NPWT)
Combination Product · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 100 Years
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 21, 2022 · Synced Sep 11, 2026, 6:04 AM EDT
Recruiting Not applicable Interventional

Negative Pressure Wound Therapy in Healing Abdominal Incision in Obese Patients Undergoing Breast Reconstruction Surgery

NCT04003038
View directory record Official record
Conditions
Body Mass Index Greater Than or Equal to 30, Malignant Breast Neoplasm, Mammoplasty Patient, Obesity
Interventions
Negative Pressure Wound Therapy, Wound Care Management
Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 11, 2026, 6:04 AM EDT
Withdrawn Not applicable Interventional

Negative Pressure Wound Therapy for Surgical Site Infection Prevention in Common Femoral Artery Exposure

NCT03935659
View directory record Official record
Conditions
Surgical Site Infection, Groin Infections
Interventions
Negative Pressure Pressure Wound Therapy, Standard Wound Care
Device · Procedure
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 9, 2021 · Synced Sep 11, 2026, 6:04 AM EDT
Active, not recruiting Not applicable Interventional

Delayed Primary Closure Using Negative Pressure Wound Therapy

NCT04042259
View directory record Official record
Conditions
Infection Abdominal
Interventions
Abthera, Open adbdomen for post-laparotomy without NPWT device
Device · Procedure
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Sep 11, 2026, 6:04 AM EDT