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Conditions: Head Injuries
Interventions: Aerobic exercise; Other
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 350 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 3
States / cities: Amherst, New York • Rochester, New York • Charleston, South Carolina

Conditions: Healthy, Carotid Artery Diseases
Interventions: Ultrasound imaging, Magnetic Resonance Imaging (MRI), Neurocognitive testing, Transcranial Doppler (TCD), Pulse Wave Doppler; Device · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 89 Years
Enrollment: 217 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Pediatric Acute Neurologic Disease, Traumatic and Non-traumatic
Interventions: Early Rehabilitation Protocol, Usual care; Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 3 Years to 17 Years
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 3
States / cities: Chicago, Illinois • Cincinnati, Ohio • Pittsburgh, Pennsylvania

Conditions: Chronic Pain
Interventions: Shared Decision Making, Motivational Interviewing and Cognitive Behavioral Therapy for Chronic Pain; Behavioral
Lead sponsor: RTI International; Other
Eligibility: 18 Years to 85 Years
Enrollment: 543 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 3
States / cities: Chapel Hill, North Carolina • Durham, North Carolina • Nashville, Tennessee

Conditions: Traumatic Brain Injury (TBI)
Interventions: Cognitive/Neuropsychological Testing, Vestibular/Ocular-Motor Testing, Cervical (Neck) Evaluation, Sleep Evaluation, HDFT MRI, MR Spectroscopy (MRS), MEG (Magnetoencephalography); Behavioral · Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 60 Years
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Carotid Artery Disease, Carotid Artery Stenosis, Stroke, Transient Ischemic Attack
Interventions: Angioplasty, Stent, Neurological and neuropsychological evaluations, Angiography; Procedure · Device · Other
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2014
U.S. locations: 1
States / cities: New York, New York

Conditions: Asymptomatic Carotid Stenosis, Symptomatic Carotid Stenosis, TCD, HITS
Interventions: Transcranial Doppler (TCD); Device
Lead sponsor: Ochsner Health System; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: NeuroQuant, Automated Neuropsychological Assessment Matrices, EDSS, Physical Examination; Other
Lead sponsor: George Washington University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder
Interventions: Cognitive Training, Aerobic Exercise, Case management and supportive psychotherapy, Individual Placement and Support; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 45 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Spinal Cord Injury, ALS (Amyotrophic Lateral Sclerosis)
Interventions: Eye Tracker, Mouth Operated Joystick, Non-invasive electroencephalogram (EEG) Headset, Implantable Brain-Computer-Interface, Personal Assistive Technology, Voice Control; Device
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Epilepsy, Post-Traumatic
Interventions: Neurology Based Collaborative Care, SOC Neurological care; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Carotid Artery Stenosis, Carotid Artery Disease, Transient Ischemic Attack, Stroke
Interventions: Carotid endarterectomy, Neurological and neuropsychological evaluations; Procedure · Other
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 817 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2014
U.S. locations: 1
States / cities: New York, New York

Conditions: Lumbar Spinal Stenosis
Interventions: Minimally Invasive Lumbar Decompression; Procedure
Lead sponsor: The Center for Pain Relief, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 2
States / cities: Charleston, West Virginia

Conditions: Congenital Heart Disease
Interventions: Not listed
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 1 Day to 2 Months
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: New York, New York

Conditions: Brain Trauma
Interventions: Conventional MRI of the brain, MR spectroscopy (MRS), MR Diffusion Tensor Imaging (DTI); Other
Lead sponsor: University of Michigan; Other
Eligibility: Not listed
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2009
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Fossa Ependymoma
Interventions: 5-Azacytidine and trastuzumab infusion; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 1 Year to 80 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Acute Brain Injury, Pupillary Reflex Impaired
Interventions: pupillometry; Other
Lead sponsor: University of Milano Bicocca; Other
Eligibility: 18 Years and older
Enrollment: 118 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 4
States / cities: San Francisco, California • Baltimore, Maryland • Seattle, Washington

Conditions: Mild Traumatic Brain Injury
Interventions: Cognitive Assessment, Patient Reported Neurological Outcome Assessments, Blood Draw; Behavioral · Procedure
Lead sponsor: BRAINBox Solutions Inc; Industry
Eligibility: 18 Years and older
Enrollment: 2,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 11
States / cities: Kansas City, Kansas • Detroit, Michigan • Rochester, New York + 5 more

Conditions: Colon Carcinoma, Colorectal Carcinoma, Rectal Carcinoma, Stage I Colon Cancer AJCC v8, Stage I Colorectal Cancer AJCC v8, Stage I Rectal Cancer AJCC v8, Stage II Colon Cancer AJCC v8, Stage II Colorectal Cancer AJCC v8, Stage II Rectal Cancer AJCC v8, Stage III Colon Cancer AJCC v8, Stage III Colorectal Cancer AJCC v8, Stage III Rectal Cancer AJCC v8
Interventions: Zanidatamab, Resection, Patient Observation, Echocardiography Test, Multigated Acquisition Scan, Endoscopic Procedure, Computed Tomography, Magnetic Resonance Imaging, Biospecimen Collection, Biopsy Procedure, Digital Rectal Examination, Electronic Health Record Review; Biological · Procedure · Other
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 4
States / cities: Atlanta, Georgia • Decatur, Georgia

Conditions: DNA Repair Disorder, Cockayne Syndrome, Xeroderma Pigmentosum, Trichothiodystrophy
Interventions: Interval History, Physical Examination, ECAB Assessment, Gait Assessment, Specimen Sample Collection; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 6 Months and older
Enrollment: 40 participants
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Parkinson's Disease, Tourette's Syndrome, Tic Disorders, Dystonia, Movement Disorders
Interventions: Transcranial Direct Current Stimulation (tDCS), Eye-tracking Device, Pulsed vibrator, Gait Trainer Treadmill (GTT), Standard psychiatric scales SCID-I, YBOCS and SCI-OBS-lifetime and cognitive scales MMSE and MOCA, iMobility, QMAT, Treadmill Test, Arm Intellistretch Device, Transcranial Sonography (TCS), Behavioral tasks, TMS single/paired pulse, MEG, EEG, MRI techniques, Peripheral Nerve Stimulation, EMG, Trancutaneous spinal direct current stimulation (tsDCS); Procedure · Device · Other + 1 more
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: 18 Years and older
Enrollment: 1,273 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2020
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Amyotrophic Lateral Sclerosis Type 4, Inherited Neurological Disorders of RNA Processing
Interventions: Not listed
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: 5 Years to 120 Years
Enrollment: 330 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2030
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Hypoxic Ischemic Encephalopathy
Interventions: Melatonin, Magnetic Resonance Imaging, Pharmacokinetics, Neurological Outcome Assessment; Drug · Other · Behavioral
Lead sponsor: University of Florida; Other
Eligibility: Up to 6 Hours
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2027
U.S. locations: 2
States / cities: Gainesville, Florida • Orlando, Florida

Conditions: IUGR, Pregnancy
Interventions: Ultrasound, MRI, Blood collection, Neurological Function Assessment, Placental Analysis, Measurement of body fat, Pediatric heart ultrasound; Radiation · Procedure · Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2028
U.S. locations: 1
States / cities: Aurora, Colorado

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Monitoring & Mitigation of Neurologic Injuries to Optimize Resilience After Repetitive Head Impacts

Early Detection of Vascular Dysfunction Using Biomarkers From Lagrangian Carotid Strain Imaging

RCT: Early Rehabilitation Protocol vs. Usual Care in the Pediatric ICU for Children With Acute Brain Injury

Integrated Services for Pain: Interventions to Reduce Pain Effectively

Targeted Evaluation, Action, & Monitoring of Traumatic Brain Injury

Neurological Outcome With Carotid Artery Stenting

Transcranial Doppler(TCD) Evaluation of High Intensity Transient Signals and Carotid Disease

Assessment of Deep Gray Matter Anatomic Changes in RRMS Patients Treated With Gilenya® With and Without Cognitive Impairment Over a 2 Year Period Using NeuroQuant, NeuroQuarc and ANAM

Enhancing Cognitive Training Through Exercise Following a First Schizophrenia Episode

Clinical Outcome Assessment for AT & BCI

Collaborative Care in Posttraumatic Epilepsy

Neuropsychometric Outcome After Carotid Endarterectomy

Vertos Mild - Post Market Patient Outcomes

Use of AEEG as Predictor of Long-term Motor Outcome in Neonates With Congenital Heart Disease

Magnetic Resonance (MR) Spectroscopy and Diffusion Tensor Imaging in Determining Brain Injury and Subsequent Clinical Outcome in Patients of Moderate Brain Trauma

Combination Intraventricular Chemotherapy Pilot Study: 5-Azacytidine (5-AZA) and Trastuzumab Infusions Into the Fourth Ventricle or Resection Cavity in Children and Adults with Recurrent or Residual Posterior Fossa Ependymoma

Outcome pRognostication of Acute Brain Injury With the NeuroloGical Pupil indEx

HEAD Injury Serum Markers and Multi-modalities for Assessing Response to Trauma

Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment

Natural History Study for DNA Repair Disorders

Physiological Investigations of Movement Disorders

Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing

Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia

Longitudinal Study of Intra-Uterine Growth Restriction