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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Nicotine Clear all
Recruiting Not applicable Interventional

Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study

NCT04949464
View directory record Official record
Conditions
HIV Infection, Tobacco-Related Carcinoma
Interventions
Computed Tomography, Smoking Cessation Intervention
Procedure · Behavioral
Lead sponsor
AIDS Malignancy Consortium
Network
Eligibility
45 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
11
States / cities
La Jolla, California • Washington D.C., District of Columbia • Tampa, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 11, 2026, 10:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Assessment of a Teachable Moment for Smoking Cessation

NCT00596440
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Transdermal nicotine patch
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 27, 2015 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Not applicable Interventional Results available

Evaluation of the Aevidum Curriculum and Club

NCT05018689
View directory record Official record
Conditions
Mental Health Wellness 1
Interventions
Aevidum curriculum, Club
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
13 Years to 21 Years
Enrollment
2,557 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 17, 2024 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Flu Shot Pre-visit Questionnaire

NCT05508698
View directory record Official record
Conditions
Influenza
Interventions
Precommitment Nudge, Salience
Behavioral
Lead sponsor
Geisinger Clinic
Other
Eligibility
18 Years and older
Enrollment
230,962 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Sep 11, 2026, 10:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Safety-Enhancing Motor Vehicle Child Safety Seat

NCT06384989
View directory record Official record
Conditions
Motor Vehicle Injury, Safety Issues
Interventions
Child restraint system with load leg feature
Other
Lead sponsor
Minnesota HealthSolutions
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 15, 2025 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Phase 1 Interventional Results available

Mindfulness-Based Ecological Momentary Intervention For Smoking Cessation Among Cancer Survivors

NCT06476548
View directory record Official record
Conditions
Any Cancer Type
Interventions
EMI
Device
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Not applicable Interventional

The Impact of Innovative Tax Proposals on Purchase Patterns

NCT05370313
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Market Price Condition (control), Tobacco Parity Tax Condition, Nicotine-Content Tax Condition, Harm-Reduction Tax Condition, Modified Risk Tobacco Product (MRTP) Tax Condition
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
285 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Buffalo, New York • Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Isradipine Enhancement of Virtual Reality Cue Exposure for Smoking Cessation

NCT03083353
View directory record Official record
Conditions
Nicotine Dependence, Smoking, Cigarette, Smoking Cessation, Smoking Behaviors, Smoking Reduction, Craving
Interventions
Isradipine, Cue Exposure
Drug · Behavioral
Lead sponsor
Jasper A. Smits
Other
Eligibility
18 Years to 65 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Human Laboratory Study Of Varenicline in Smokers

NCT00709696
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Placebo, Varenicline
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 26, 2017 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Not applicable Interventional Results available

Brain Stimulation For Cancer Smokers

NCT03419741
View directory record Official record
Conditions
Cancer of Head and Neck, Breast Cancer, Prostate Cancer, Nicotine Dependence
Interventions
Transcranial Magnetic Stimulation Clinical Research System
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 12, 2022 · Synced Sep 11, 2026, 10:16 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Nicotine Withdrawal and Reward Processing: Connecting Neurobiology to Real-world Behavior

NCT03840694
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Withdrawal
Interventions
Smoking Abstinence, Ad Lib Smoking
Other
Lead sponsor
Duke University
Other
Eligibility
21 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Smoking Abstinence and Lapse Effects in Smokers With Schizophrenia and Controls

NCT01214005
View directory record Official record
Conditions
Tobacco Use Disorder, Schizophrenia
Interventions
smoking abstinence
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 26, 2012 · Synced Sep 11, 2026, 10:16 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Abuse Liability and Appeal of Oral Nicotine Products

NCT06506162
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Flavor, Nicotine concentration
Other
Lead sponsor
University of Southern California
Other
Eligibility
21 Years to 25 Years
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Selected Constituents in the Exhaled Breath Samples

NCT04143256
View directory record Official record
Conditions
Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
Interventions
JUUL ENDS 5% Virginia Tobacco, JUUL 3% Virginia Tobacco ENDS, JUUL 5% Mint ENDS, JUUL 3% Mint ENDS, JUUL 5% Menthol ENDS, JUUL 3% Menthol ENDS, JUUL 5% Mango ENDS, JUUL 3% Mango ENDS, US Cigarette, Non-menthol - Marlboro Gold King Size, US Cigarette, Menthol - Newport King Size
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
3
States / cities
Secaucus, New Jersey • Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 10, 2020 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia

NCT00770237
View directory record Official record
Conditions
Schizophrenia, Nicotine Dependence
Interventions
Smoking Cues, Neutral Cues
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 64 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 18, 2019 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Not applicable Interventional

Michigan Youth Violence Prevention Center: Building Evidence for Gun Violence Prevention - SafERteens Implementation

NCT05821205
View directory record Official record
Conditions
Violence in Adolescence
Interventions
Narrative Persuasion, Reciprocity, Personalized Feedback, Commitment
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
6
States / cities
Ann Arbor, Michigan • Fruitport, Michigan • Muskegon, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 11, 2026, 10:16 PM EDT
Recruiting Phase 4 Interventional

Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

NCT07145866
View directory record Official record
Conditions
Nicotine Dependence, Transcranial Magnetic Stimulation, Vaping, Smoking Cessation, Smoking (Tobacco) Addiction
Interventions
Varenicline, Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham, Nicotine Cessation Counseling, D-cycloserine
Drug · Device · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Manipulating Tobacco Constituents in Male Menthol Smokers

NCT02592772
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Reduced Nicotine Non-Menthol (RNC), Reduced Nicotine Menthol (RNC-Men), Conventional Nicotine Non-Menthol (CN)
Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
2
States / cities
Farmington, Connecticut • Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 8, 2020 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Phase 2 Interventional Results available

Evaluation of the Nicotine Lozenge in Relief of Provoked Acute Craving

NCT01466361
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Nicotine lower dose, Nicotine higher dose, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Maintaining Nonsmoking

NCT01162239
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Initial Individual counseling, Check-ins with medical staff, Extended Individual Counseling - Health Model, Extended Individual Counseling - Relapse Prevention Model
Drug · Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 11, 2020 · Synced Sep 11, 2026, 10:16 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder

NCT03745339
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Addiction
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 60 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Sep 11, 2026, 10:16 PM EDT
Completed No phase listed Observational

Behavioral Economics of Human Drug Self-Administration

NCT00005765
View directory record Official record
Conditions
Drug Dependence
Interventions
nicotine, alcohol
Drug
Lead sponsor
National Center for Research Resources (NCRR)
NIH
Eligibility
21 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD201203: A Study to Determine Subject Puffing Patterns of a Non-cylindrical, Closed, Electronic Nicotine Delivery System at Three Nicotine Concentrations in an Ambulatory Setting

NCT05118139
View directory record Official record
Conditions
Smoking, Tobacco Use, Electronic Cigarette Use
Interventions
P1211216, P1213416, P1213716, P1213616, P1213816, P1211916, P1210016, P1211217, P1213417, P1211222, P1213422, P1213722, P1213622, P1213822, P1211922, P1210022
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
4
States / cities
Stockbridge, Georgia • Lexington, Kentucky • Hickory, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Sep 11, 2026, 10:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sex Differences in E-cig Perception: Study 1

NCT05432830
View directory record Official record
Conditions
Nicotine Addiction, E-Cig Use, Cigarette Smoking, Sex Differences
Interventions
E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3
Other
Lead sponsor
Yale University
Other
Eligibility
21 Years to 44 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Sep 11, 2026, 10:16 PM EDT