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ClinicalTrials.gov public records Last synced Sep 30, 2026, 5:51 PM EDT

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Showing 25–48 of 66 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Nicotine 0% Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers

NCT03625986
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Nicotine-Containing Electronic Cigarette, Non-Nicotine Electronic Cigarette
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of e-Cigarettes on Perceptions and Behavior

NCT03742817
View directory record Official record
Conditions
Electronic Cigarettes
Interventions
e-Cigarette
Other
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 11, 2023 · Synced Sep 30, 2026, 5:51 PM EDT
Recruiting Phase 1 Interventional

Tocilizumab-aazg for Hemorrhage: Reduction of Ischemic Vascular Events

NCT06863480
View directory record Official record
Conditions
Aneurysmal Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
Interventions
tocilizumab-aazg (TYENNE)
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 89 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Sep 30, 2026, 5:51 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Thrive Initiative Parent-Education Programming Study

NCT06823518
View directory record Official record
Conditions
Child Maltreatment, Parenting, Child Wellbeing
Interventions
Thrive Initiative Parent-Education Programming
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
18 Years and older
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Web-based Implementation for the Science of Enhancing Resilience Study

NCT02603133
View directory record Official record
Conditions
Burnout, Professional, Resilience, Psychological
Interventions
Three Good Things, Gratitude, Random Acts of Kindess, Awe, 1 Good Chat
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 85 Years
Enrollment
2,650 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
9
States / cities
Palo Alto, California • Stanford, California • Boston, Massachusetts + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2023 · Synced Sep 30, 2026, 5:51 PM EDT
Terminated Phase 3 Interventional Results available

Study to Determine if a New Nicotine Replacement Therapy Can Safely Help Smokers to Quit Smoking

NCT01296698
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Placebo, Nicotine
Drug
Lead sponsor
McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Industry
Eligibility
18 Years and older
Enrollment
257 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
19
States / cities
Muscle Shoals, Alabama • Oceanside, California • Griffin, Georgia + 16 more
Source: ClinicalTrials.gov public record
Updated Apr 23, 2012 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Phase 4 Interventional Results available

Nicotine as an Adjuvant Analgesic for Third Molar Surgery

NCT00385216
View directory record Official record
Conditions
Dental Crowding
Interventions
Nicotine, Placebo
Drug · Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Electronic Cigarette Liquid Characteristics in Smokers.

NCT03861078
View directory record Official record
Conditions
Electronic Cigarettes
Interventions
Own Brand Cigarette, ECIG 15 mg nicotine, sweetened, ECIG 15 mg nicotine, unsweet, ECIG 0 mg nicotine, sweetened, ECIG 0 mg nicotine, unsweet
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 55 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 23, 2022 · Synced Sep 30, 2026, 5:51 PM EDT
Terminated Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Pioglitazone for Heroin and for Nicotine Dependence

NCT01395797
View directory record Official record
Conditions
Heroin Dependence, Nicotine Dependence
Interventions
PIO, Placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 13, 2017 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Not applicable Interventional Results available

Tech and Telephone Smoking Cessation Treatment for Young Veterans With PTSD

NCT03552978
View directory record Official record
Conditions
Smoking Cessation
Interventions
Tech-Facilitated IC Intervention, VA Quitline
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 45 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Not applicable Interventional Results available

Changes in Biomarkers Associated With Use of Electronic Cigarettes

NCT03084315
View directory record Official record
Conditions
Biomarkers
Interventions
E-Cig Zero Nicotine, E-Cig 24mg Nicotine
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Sep 30, 2026, 5:51 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

MicroRNA Correlates of Childhood Maltreatment and Suicidality

NCT04923685
View directory record Official record
Conditions
Major Depressive Disorder, Suicidal Ideation
Interventions
Trier Social Stress Test
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 60 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
2
States / cities
Birmingham, Alabama • Huntsville, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessing Electronic Cigarette Nicotine Flux

NCT04378907
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Cigarette Smoker/ECIG users: 0 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 6 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 15 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 30 mg/ml nicotine concentration
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Evaluating the Pharmacokinetics and Drug Interaction Potential of the Botanical Dietary Supplement Cinnamon

NCT05157672
View directory record Official record
Conditions
Interaction Drug Food
Interventions
Cinnamon (2 g), Nicotine gum (2.5 mg), Letrozole (2.5 mg)
Dietary Supplement · Drug
Lead sponsor
Washington State University
Other
Eligibility
18 Years to 64 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures

NCT05205382
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
5% nicotine (Partial Nicotine Reduction), 3% or 2.4% nicotine (Partial Nicotine Reduction), 5% nicotine (Total Nicotine Reduction), 0% nicotine (Total Nicotine Reduction)
Other
Lead sponsor
Florida International University
Other
Eligibility
21 Years to 35 Years
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessing the Effect of Flavor on ENDS Users' Experiences and Exposures

NCT04192032
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Preferred Juul pod flavor (5% nicotine), Classic Tobacco Juul pod flavor (5% nicotine), Preferred flavor with HWL, Preferred flavor, 3% nicotine, Preferred flavor, 0% nicotine
Other
Lead sponsor
Florida International University
Other
Eligibility
18 Years to 24 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Sep 30, 2026, 5:51 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Effect of Cannabis on Cigarette Use Behavior

NCT06609083
View directory record Official record
Conditions
Cannabis Use, Tobacco Use, Cigarette Smoking
Interventions
THC 30mg, THC 5mg, THC 0mg, Cigarette Full Nicotine, Cigarette Reduced Nicotine
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)

NCT04332926
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Tobacco product administration and assessment, own brand cigarettes, Tobacco product administration and assessment, ECIG 30 Watts, 0 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 8 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 15 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 30 mg/ml nicotine
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Attention Deficit Hyperactivity Disorder (ADHD) Smoking Cessation Study

NCT00736255
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder, Nicotine Dependence
Interventions
Transdermal Nicotine Patch, Lis-dexamphetamine (Vyvanse), Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 30, 2018 · Synced Sep 30, 2026, 5:51 PM EDT
Recruiting Phase 1 Interventional

Effects of Cannabidiol on Stress and Nicotine Withdrawal

NCT07001930
View directory record Official record
Conditions
CBD, Stress, Nicotine Dependence, Tobacco Smoking
Interventions
Epidiolex
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 70 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 30, 2026, 5:51 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Effect of Cannabis on E-Cigarette Use Behavior

NCT06609109
View directory record Official record
Conditions
Cannabis Use, Tobacco Use, Electronic Cigarette Use
Interventions
THC High Dose, THC Low Dose, THC 0mg, E-Cigarette Full Nicotine, E-Cigarette Placebo Nicotine
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Study of TA-NIC to Assess the Efficacy and Safety of the Vaccine as an Aid to Smoking Cessation

NCT00633321
View directory record Official record
Conditions
Smoking
Interventions
TA-NIC, Placebo
Biological
Lead sponsor
Celtic Pharma Development Services
Industry
Eligibility
18 Years and older
Enrollment
522 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
9
States / cities
Sacramento, California • Metairie, Louisiana • Columbia, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2011 · Synced Sep 30, 2026, 5:51 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration

NCT05999383
View directory record Official record
Conditions
THC, Cannabis, Cannabis Use, Cannabis Smoking, Tobacco Use, Vaping
Interventions
Cannabis, Nicotine, Pax Loose Leaf Vaporizer, Placebo Marijuana
Drug · Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 30, 2026, 5:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pharmacokinetics of Nicotine Film in Smokers

NCT02239770
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicotine Film, Placebo Nicotine Film
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 31, 2018 · Synced Sep 30, 2026, 5:51 PM EDT