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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Nicotine Patch Therapy Clear all
Recruiting Phase 1Phase 2 Interventional

Overcoming Nicotine Dependence to Enable Quitting

NCT05513872
View directory record Official record
Conditions
Tobacco Use, Smoking Cessation, Smoking Behaviors, Nicotine Dependence, Nicotine Withdrawal
Interventions
Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling
Drug · Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
780 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 27, 2026, 9:56 AM EDT
Terminated Early Phase 1 Interventional

Smoking Cessation Treatment for Head and Neck Cancer Patients

NCT00931021
View directory record Official record
Conditions
Smoking Cessation
Interventions
Varenicline (Chantix), Nicotine Patch
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 14, 2013 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Phase 4 Interventional

Behavioral Counseling for Alcohol Dependent Smokers (Nicotine Patch)

NCT00004551
View directory record Official record
Conditions
Alcoholism, Smoking
Interventions
nicotine replacement patch, mood management
Drug · Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2003
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 28, 2010 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Not applicable Interventional Results available

Mindfulness-based Smoking Cessation Enhanced With Mobile Technology

NCT04965181
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Mindfulness-Based Addiction Treatment, Nicotine Replacement Therapy, Self-help materials, iQuit Mindfully
Behavioral · Drug
Lead sponsor
Georgia State University
Other
Eligibility
18 Years and older
Enrollment
504 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Phase 3 Interventional Results available

Pharmacogenetics of Nicotine Addiction Treatment

NCT01314001
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Varenicline, Placebo, Transdermal Nicotine
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
1,246 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
3
States / cities
Buffalo, New York • Philadelphia, Pennsylvania • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 2, 2016 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Phase 3 Interventional Results available

Evaluation of a Tailored Smoking Cessation Treatment Algorithm Based on Initial Treatment Response and Genotype

NCT00894166
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicotine Patches, Nicotine patches, then bupropion & nicotine patches (Pre-Quit), Nicotine patches, then varenicline (Pre-Quit), Nicotine patches, then nicotine patches (Pre-Quit), Nicotine patches, then bupropion & nicotine patches (Post-Quit), Nicotine patches, then varenicline (Post-Quit), Nicotine patches, then nicotine patches (Post-Quit)
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
606 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Charlotte, Durham, Raleigh, Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 22, 2013 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Youth Smoking Cessation: Therapy +/- "The Patch"

NCT00631020
View directory record Official record
Conditions
Smoking
Interventions
CBME, Optional NRT
Behavioral · Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
14 Years to 21 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 21, 2015 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Phase 4 Interventional Results available

A Comparative Effectiveness RCT of Optimized Cessation Treatments

NCT02301403
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicotine patch, in-person counseling and quitline counseling, Preparation Nicotine Mini-Lozenges, Combination NRT (nicotine patch + nicotine mini-lozenges), Intensive In-Person Cessation Counseling, Extended Maintenance Counseling Calls, Automated Adherence Calls
Drug · Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
623 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 12, 2020 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Nicotine Patch Pretreatment for Smoking Cessation in PTSD

NCT00625131
View directory record Official record
Conditions
Stress Disorders, Posttraumatic, Tobacco Use Disorder
Interventions
Nicotine, Cognitive Behavioral Therapy for Smoking Cessation, Bupropion Sustained Release (SR), Placebo patch
Drug · Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 70 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 19, 2014 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Phase 4 Interventional

Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone)

NCT00000437
View directory record Official record
Conditions
Alcoholism, Smoking
Interventions
Naltrexone Tablet and Nicotine Patch, Naltrexone Tablet and Placebo Patch, Placebo Tablet and Nicotine Patch, Placebo Tablet and Placebo Patch
Drug
Lead sponsor
The Scripps Research Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2005
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 19, 2017 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Not applicable Interventional

Motivation and Nicotine Patch Treatment for Under-served Smokers

NCT01684995
View directory record Official record
Conditions
Smoking Cessation
Interventions
Brief physician advice, nicotine patch, Individually Tailored Behavioral Skills training
Behavioral · Drug
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years and older
Timeline
1996 – 1999
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 12, 2012 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Phase 2 Interventional Results available

Nicotinic Treatment of Post-Chemotherapy Subjective Cognitive Impairment: A Pilot Study

NCT02312934
View directory record Official record
Conditions
Chemo Brain, Chemotherapy-related Cognitive Impairment, Chemo Fog, Breast Cancer, Chemobrain
Interventions
Transdermal nicotine, Placebo Transdermal Patch
Drug · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
35 Years to 80 Years · Female only
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Genetically Informed Smoking Cessation Trial

NCT02351167
View directory record Official record
Conditions
Smoking Cessation
Interventions
Combination NRT (Nicotine patch, Nicotine lozenge), Varenicline, Placebo, Intensive smoking counseling
Drug · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
21 Years and older
Enrollment
822 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Sep 27, 2026, 9:56 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation

NCT02697227
View directory record Official record
Conditions
Cigarette Smoker, Tobacco Use Disorder
Interventions
Behavioral Intervention, Laboratory Biomarker Analysis, Nicotine Patch, Questionnaire Administration, Smoking Cessation Intervention
Behavioral · Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 75 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Sep 27, 2026, 9:56 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Nicotine Receptor Density & Response to Nicotine Patch

NCT01526005
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Transdermal Nicotine Patch, Transdermal Placebo Patch
Drug
Lead sponsor
Brentwood Biomedical Research Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2012
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 26, 2015 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Phase 3 Interventional Results available

Behavioral Activation Intervention, Reward Processing, and Youth Smoking Cessation

NCT01351766
View directory record Official record
Conditions
Smoking
Interventions
Transdermal Nicotine Patch
Drug
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 21 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 17, 2022 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Phase 2 Interventional Results available

Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 1: Nicotine Replacement Therapy

NCT00699556
View directory record Official record
Conditions
Alcohol Drinking
Interventions
21mg transdermal nicotine patch (Nicoderm CQ), 1mg nicotine nasal spray, placebo nasal spray
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2016
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 11, 2018 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Not applicable Interventional

Women Engaging in Quitting Smoking Together

NCT02453659
View directory record Official record
Conditions
Smoking Cessation
Interventions
Distress Tolerance Treatment for Weight Concern (DT-W), Health Education (HE), Smoking Cessation counseling, Transdermal Nicotine Patch
Behavioral · Drug
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 27, 2019 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Applying mHealth to Tobacco-related Health Disparities

NCT03404596
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicotine Patch, Counseling, Smartphone, AutoSense
Drug · Behavioral · Other
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 10, 2023 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Patch, Blood Flow and Oxidative Stress Study

NCT00954096
View directory record Official record
Conditions
Healthy
Interventions
transdermal nicotine patch (7mg)
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 45 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 26, 2009 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Not applicable Interventional Results available

Quit For Life (QFL): Smoking Cessation Among Chinese Smokers Living With HIV

NCT05020899
View directory record Official record
Conditions
Smoking Cessation, HIV Infections
Interventions
Sessions with a trained counselor, Cell phone messages, Offered nicotine replacement therapy, Self-help guide for quitting smoking
Behavioral · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 11, 2024 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Evoked Responses as Pharmacodynamic Biomarkers in Healthy and Schizophrenic Participants (MK-4334-007)

NCT05136690
View directory record Official record
Conditions
Cognitive Impairment Associated With Schizophrenia
Interventions
Nicotine patch, MK-4334, Placebo patch, Placebo capsule
Drug
Lead sponsor
Merck Sharp & Dohme LLC
Industry
Eligibility
18 Years to 55 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
2
States / cities
Long Beach, California • Marlton, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 28, 2024 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Remote vs. In-Person Study Evaluation (RISE) Trials: RISE Above Smoking (Trial 1)

NCT06822049
View directory record Official record
Conditions
Remote vs. In-Person, Remote Visits, In-person Visits
Interventions
Combination Nicotine Replacement Therapy (patch and lozenge)
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 99 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
2
States / cities
Buffalo, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Sep 27, 2026, 9:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Randomized Trial of Internet Access to Nicotine Patches

NCT00534404
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Disorder
Interventions
Nicotine patches, Telephone counseling, iQuit Smoking website
Drug · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
2,485 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 2, 2015 · Synced Sep 27, 2026, 9:56 AM EDT