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ClinicalTrials.gov public records Last synced Oct 13, 2026, 4:49 PM EDT

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Showing 193–216 of 423 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Nicotine Replacement Therapies Clear all
Terminated No phase listed Observational Accepts healthy volunteers

Smoking Cessation Program: A Quality Improvement Trial in a Resident-Based Outpatient Clinic

NCT00436943
View directory record Official record
Conditions
Smoking
Interventions
nicotine replacement therapy and bupropion, smoking cessation counseling and referrals
Drug · Behavioral
Lead sponsor
Atlantic Health System
Other
Eligibility
21 Years and older
Enrollment
900 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 12, 2010 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Neuroimaging Reward, Behavioral Treatment, and Smoking Cessation

NCT02927847
View directory record Official record
Conditions
Smoking
Interventions
Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (.03 mg), Behavioral Activation, Supportive Counseling
Drug · Behavioral
Lead sponsor
Maggie M Sweitzer, PhD
Other
Eligibility
18 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Phase 4 Interventional

Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch)

NCT00000447
View directory record Official record
Conditions
Alcoholism, Smoking
Interventions
naltrexone (Revia), nicotine replacement patch
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 50 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2003
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2010 · Synced Oct 13, 2026, 4:49 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Episodic Future Thinking and Future Thinking Priming for Smoking Cessation

NCT04297332
View directory record Official record
Conditions
Tobacco-Related Carcinoma
Interventions
Behavioral Intervention, Informational Intervention, Nicotine Replacement, Telephone-Based Intervention
Behavioral · Other · Drug
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Oct 13, 2026, 4:49 PM EDT
Completed No phase listed Observational Results available

Evaluation of a Smoking Cessation Program for Long-Term Abstinence

NCT06746025
View directory record Official record
Conditions
Nicotine Addiction, Smoking Cessation
Interventions
Quit Center cessation program
Behavioral
Lead sponsor
Quit Center LLC
Industry
Eligibility
18 Years and older
Enrollment
371 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Naples, Florida
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Exenatide Once Weekly for Smoking Cessation

NCT02975297
View directory record Official record
Conditions
Smoking Cessation
Interventions
Exenatide, NRT, Counseling, Placebo
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 75 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Not applicable Interventional Results available

Take a Break (TAB): mHealth-assisted Skills Building Challenge for Unmotivated Smokers

NCT02973425
View directory record Official record
Conditions
Smoking Cessation
Interventions
Take a Break as an augmentation to NRT-sampling in Motivation Phase, NRT and mHealth assessment tool without feedback
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
433 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
4
States / cities
Worcester, Massachusetts • Great Neck, New York
Source: ClinicalTrials.gov public record
Updated Aug 11, 2022 · Synced Oct 13, 2026, 4:49 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Treating Adults at Risk for Weight Gain With Interactive Technology

NCT01199185
View directory record Official record
Conditions
Smoking, Body Weight
Interventions
Smoking Cessation, Smoking Cessation plus Weight Loss
Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 35 Years
Enrollment
330 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 18, 2013 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Remote vs. In-Person Study Evaluation (RISE) Trials: RISE Above Smoking (Trial 1)

NCT06822049
View directory record Official record
Conditions
Remote vs. In-Person, Remote Visits, In-person Visits
Interventions
Combination Nicotine Replacement Therapy (patch and lozenge)
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 99 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
2
States / cities
Buffalo, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Improving Quitline Support Study

NCT03538938
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
1-Call Quitline Counseling, 4-Call Quitline Counseling, Nicotine patch, Nicotine Patch and Nicotine Lozenge, SmokefreeTXT, No SmokefreeTXT, Financial Incentives for Treatment Engagement, No Financial Incentives for Treatment Engagement
Behavioral · Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
1,316 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 12, 2024 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Tobacco Treatment Strategies for Inpatient Psychiatry

NCT00968513
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Brief Intervention, Extended Treatment, Usual Care
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
956 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
3
States / cities
Berkeley, California • San Francisco, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Heart Rate Variability Biofeedback for Smoking Cessation Treatment

NCT05224050
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Cognitive-Behavioral Smoking Cessation, Heart Rate Variability Biofeedback, Nicotine patch
Behavioral · Biological · Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
21 Years to 50 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 1, 2024 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Phase 1 Interventional

Tobacco Cessation in Postmenopausal Women (Part II) - 2

NCT00061074
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Nicotrol
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
40 Years to 79 Years · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 2000
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 2, 2015 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Text Messaging-Based Smoking Cessation Program for Homeless Youth

NCT03874585
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Group counseling and nicotine replacement, Group counseling, nicotine replacement, and text messaging support
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years to 25 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
3
States / cities
Los Angeles, California • Venice, California
Source: ClinicalTrials.gov public record
Updated Jul 22, 2020 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Phase 4 Interventional Results available

Testing C-Raven, a Virtual Tobacco Cessation Intervention, in the Community

NCT06289192
View directory record Official record
Conditions
Tobacco Dependence
Interventions
C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker, Lung Cancer Screening
Behavioral · Drug · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
3
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interventions for Smoking Among Persons in Recovery

NCT00714896
View directory record Official record
Conditions
Smoking Cessation
Interventions
Stepped-Care, Control
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Walnut Creek, California
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Nicotine Lozenge Bioequivalence Study

NCT01536704
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicotine (2 mg), Nicotine (4 mg)
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
19 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Apr 26, 2013 · Synced Oct 13, 2026, 4:49 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation

NCT07099638
View directory record Official record
Conditions
Smoking Cessation
Interventions
Varenicline (VAR), Nicotine lozenge (NRT), Smartphone intervention with adherence components (COMBO-A), Smartphone intervention without adherence components (COMBO-B), Telephone Counseling
Drug · Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
496 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 13, 2026, 4:49 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid

NCT07694492
View directory record Official record
Conditions
Tobacco Use Cessation, Tobacco Use Disorder, Nicotine Dependence, Smokeless Tobacco Use
Interventions
QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT)
Behavioral · Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Contingency Management, Quitting Smoking, and ADHD

NCT02266784
View directory record Official record
Conditions
Cigarette Smoking, Smoking Cessation
Interventions
Contingency Management (CM), Transdermal nicotine skin patches (i.e. Habitrol), Supportive Counseling
Behavioral · Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 13, 2026, 4:49 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Semaglutide for Post-Smoking Cessation Weight Management

NCT06173778
View directory record Official record
Conditions
Obesity, Overweight, Cigarette Smoking
Interventions
semaglutide 2.4mg, Placebo, Nicotine Replacement Therapy (NRT, nicotine patch), Brief Smoking Cessation Counseling
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 75 Years
Enrollment
197 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
2
States / cities
Austin, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Not applicable Interventional

Feasibility of a Culturally-Specific Video Text Cessation Intervention With AA Quitline Callers

NCT03927976
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Path2Quit - culturally specific text message intervention
Behavioral
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 16, 2020 · Synced Oct 13, 2026, 4:49 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

The Impact of Smoking on Outcomes and Complications in Total Joint Arthroplasty: A Prospective Crossover Study

NCT04592302
View directory record Official record
Conditions
Smoking, Total Joint Arthroplasty
Interventions
Blood Draw
Diagnostic Test
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years to 99 Years
Enrollment
1,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 13, 2026, 4:49 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Tobacco Cessation Via Public Health Dental Clinics

NCT00683839
View directory record Official record
Conditions
Smoking
Interventions
Brief tobacco counseling
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
18 Years and older
Enrollment
2,637 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
3
States / cities
Jackson, Mississippi • New York, New York • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 26, 2011 · Synced Oct 13, 2026, 4:49 PM EDT