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Conditions: Tobacco Use Disorder, Tobacco Dependence
Interventions: Quitbuddy, Control, SDoH Augmentation, SDoH Control; Other
Lead sponsor: Bryan W. Heckman; Other
Eligibility: 21 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Tobacco Dependence
Interventions: C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker, Lung Cancer Screening; Behavioral · Drug · Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 50 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking, Smoking Cessation, HIV Infections
Interventions: Nicotine Replacement Therapy, Mindfulness Training Smoking Cessation Intervention, Contingency Management Smoking Cessation Intervention; Drug · Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Smoking, Smoking Cessation
Interventions: Comprehensive Relapse Prevention Intervention, Standard Treatment Counseling, Nicotine Replacement Therapy (NRT); Behavioral · Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 100 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking Cessation, Tobacco Use Cessation
Interventions: Smoking cessation counseling (Quitline), Smoking cessation pharmacotherapy (e.g, nicotine replacement therapy), Financial incentives for smoking cessation, Financial incentives for use of evidence-based smoking cessation therapies; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 1,058 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 2
States / cities: Los Angeles, California • New York, New York

Conditions: Smoking, Bipolar Disorder
Interventions: Experimental plus Nicotine Replacement Therapy, Control plus Nicotine Replacement Therapy; Behavioral
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 4
States / cities: Palo Alto, California • Denver, Colorado • Bedford, Massachusetts + 1 more

Conditions: Tobacco Use Disorder
Interventions: Cue Extinction Training, Nicotine Replacement Therapy, Cue Extinction Therapy, Progressive Muscle Relaxation; Behavioral · Drug
Lead sponsor: Columbia University; Other
Eligibility: 21 Years to 60 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Nicotine Dependence
Interventions: Nicoderm CQ transdermal nicotine, placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 45 Years
Enrollment: 87 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Cessation
Interventions: Mailed nicotine replacement therapy, Text messaging, Brief advice; Drug · Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 153 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking, Smoking Cessation, Physical Inactivity
Interventions: Actívatexto, Decídetexto; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 408 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Smoking Cessation, Diabetes Type 2
Interventions: Contingency Management, Usual Care smoking cessation; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 75 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Cigarette Smoking
Interventions: Smoking cessation guideline implementation; Behavioral
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years and older
Enrollment: 789 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 2
States / cities: Des Moines, Iowa • Iowa City, Iowa

Conditions: Tobacco Use Cessation
Interventions: Varenicline, Nicotine Patch, Placebo Patch, Placebo Tablet, Questionnaires, Counseling Sessions, Lab Session, Saliva Test; Drug · Behavioral · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 204 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Current Smoker, Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma, Laryngeal Squamous Cell Carcinoma, Nasopharyngeal Carcinoma, Oral Cavity Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma
Interventions: Bupropion Hydrochloride, Laboratory Biomarker Analysis, Nicotine Replacement, Quality-of-Life Assessment, Questionnaire Administration, Varenicline; Drug · Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 2
States / cities: Winston-Salem, North Carolina • Charleston, South Carolina

Conditions: Smokeless Tobacco Cessation
Interventions: Commit® nicotine lozenges (4 mg) & self-help materials, Commit® nicotine lozenges (4 mg) & phone counseling & self-help materials, Phone counseling & self-help materials; Drug · Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 1,067 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Smoking Cessation
Interventions: Phone-based Tobacco Treatment, Nicotine Replacement, and Stepped Care Intervention, E-Referral to the Tobacco Quitline; Behavioral
Lead sponsor: Georgetown University; Other
Eligibility: 50 Years to 80 Years
Enrollment: 1,188 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Smoking, Pulmonary Disease, Chronic Obstructive, Tobacco Use Disorder
Interventions: Standard Smoking Cessation, Extended Nicotine Replacement Therapy, Nicotine replacement therapy; Other · Drug
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 398 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Smoking Cessation
Interventions: Telephone Counseling, Nicotine Patches; Behavioral · Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 243 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: San Diego, California

Conditions: Tobacco Dependence
Interventions: Usual care, Lung age, Contingency Management, Lung age + Contingency Management; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking Cessation
Interventions: individualized counselor-led MI sessions, general health education session, NRT; Behavioral
Lead sponsor: Temple University; Other
Eligibility: 18 Years to 110 Years
Enrollment: 139 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Cessation
Interventions: Treatment As Usual (TAU), Nicotine Replacement Therapies, Text Message Intervention (TMI); Other · Drug · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 203 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
Interventions: Nicotine Replacement Therapies, Brief Behavioral Counseling; Drug · Behavioral
Lead sponsor: West Virginia University; Other
Eligibility: 21 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Greenville, North Carolina • Morgantown, West Virginia

Conditions: Smoking Reduction or Abstinence
Interventions: In vivo counseling, Standard Smoking Cessation Counseling; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 517 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Smokeless Tobacco Cessation
Interventions: #EnufSnuff.TXT- First Responder, Enough Snuff Intervention; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Durham, North Carolina

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Equitable Smoking Relapse Prevention

C-Raven, a Virtual Tobacco Cessation Intervention in Residency Clinics

Testing Integrative Smoking Cessation for HIV Patients

Preventing Smoking Relapse After Total Joint Replacement Surgery

Financial Incentives for Smoking Treatment II

Web-Delivered Acceptance & Commitment Therapy for Smokers With Bipolar Disorder

Effects of Nicotine Replacement and Repeated Cue Exposure on Cigarette Craving

Assessment of High Dose Transdermal Nicotine for Fast Metabolizers of Nicotine

A Text Messaging Program for Smokers in Primary Care

Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos

Diabetes Smoking Cessation Incentives Study

The Effectiveness of Smoking Cessation Guidelines in the Emergency Department

Reward Sensitivity and Pharmacotherapy for Smoking Cessation

Bupropion Hydrochloride or Patient's Choice for Smoking Cessation in Patients With Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy

Nicotine Lozenges and Assisted Self-help for Smokeless Tobacco Cessation

Tobacco Education and Lung Health Study (TEAL)

Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers

Smoking Cessation With the Nicotine Patch: A Pilot Study of Patch Messaging

A Study of Novel Smoking Cessation Interventions in Current and Former Injection Drug Users

Smoking Cessation in NYC

A Pilot Text Messaging Intervention to Reduce Smoking in Office-based Buprenorphine and Inpatient Detoxification Patients

Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use

In Vivo Experience With NRT to Increase Adherence and Smoking Abstinence

Smokeless Tobacco Cessation Intervention for Firefighters