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Showing 1–24 of 96 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Nicotine containing cigarette Clear all
Completed Phase 2 Interventional

Clinical Study of Smoke-Break Liquid Cigarettes

NCT00715871
View directory record Official record
Conditions
Smoking
Interventions
Nicotine, Smoke-Break nicotine delivery device
Drug · Device
Lead sponsor
Smoke-Break, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
West Allis, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 18, 2014 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Phase 1 Interventional

Investigation of Nicotine Seeking Behavior in Current Smokers

NCT03670212
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Yohimbine Hydrochloride, Hydrocortisone, Lactose Monohydrate Powder
Drug
Lead sponsor
Wayne State University
Other
Eligibility
21 Years to 35 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 12, 2018 · Synced Sep 3, 2026, 6:55 PM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Effects of Progesterone on Smoked Nicotine Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effects

NCT01636336
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine, Progesterone
Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2016
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 14, 2013 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Controlled Trial to Evaluate the Impact of ZYN Nicotine Pouch Products on Cigarette Usage and BoExp in Adult Smokers Over a 12-week Period

NCT06568900
View directory record Official record
Conditions
Tobacco Use
Interventions
cigarette smoking, tobacco flavored and unflavored pouch, unrestricted flavor options pouch
Other
Lead sponsor
Swedish Match AB
Industry
Eligibility
22 Years to 65 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Sep 3, 2026, 6:55 PM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Multiple Cigarette Induced Changes in Hormone Function, Mood States and Behavior

NCT01636310
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine
Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2016
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 14, 2013 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Biomarkers of Exposure and Biomarkers of Potential Harm in Adult Smokers Who Completely Switch to E-vapor Products

NCT04800211
View directory record Official record
Conditions
Tobacco Use
Interventions
Experimental: Test Product 1, Experimental: Test Product 2
Other
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
30 Years to 65 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
10
States / cities
Burbank, California • Wichita, Kansas • Lexington, Kentucky + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Behavioral Memory Modulation in Nicotine Addiction

NCT03744559
View directory record Official record
Conditions
Nicotine Use Disorder
Interventions
Retrieval Extinction Training (RET), Control Retrieval Extinction Training (RET)
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
25 Years to 65 Years
Enrollment
191 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in Smokers

NCT01337830
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
Ariva® Silver Wintergreen, Silver Wintergreen
Other
Lead sponsor
Star Scientific, Inc
Industry
Eligibility
23 Years to 72 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Martinsburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 23, 2014 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Innovative Interventions for Smoking Cessation

NCT01050569
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Nicotine Patch, VLNC Cigarette, VLNC Cigarette Plus Nicotine Patch
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
235 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
2
States / cities
Duluth, Minnesota • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 17, 2019 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Phase 2 Interventional Results available

The Role of Nicotine Dose and Route of Delivery in Affecting Adoption of E-cigarettes and Reducing Exposure to Toxic Combustion Products

NCT03492463
View directory record Official record
Conditions
Nicotine Dependence, Cigarettes
Interventions
Nicotine patch, Placebo patch, E-cigarettes, Non-nicotine e-cigarettes
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 3, 2026, 6:55 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Effect of Cannabis on Cigarette Use Behavior

NCT06609083
View directory record Official record
Conditions
Cannabis Use, Tobacco Use, Cigarette Smoking
Interventions
THC 30mg, THC 5mg, THC 0mg, Cigarette Full Nicotine, Cigarette Reduced Nicotine
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Not applicable Interventional Results available

Testing the Effect of ENDS Flavors on Neurotransmission

NCT05836051
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Flavor
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Manipulating Tobacco Constituents in Male Menthol Smokers

NCT02592772
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Reduced Nicotine Non-Menthol (RNC), Reduced Nicotine Menthol (RNC-Men), Conventional Nicotine Non-Menthol (CN)
Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
2
States / cities
Farmington, Connecticut • Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 8, 2020 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use

NCT02870218
View directory record Official record
Conditions
Nicotine Addiction, Cigarette Smoking
Interventions
Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds
Drug
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 13, 2022 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

BRP1602: Evaluation of Technical and Logistical Feasibility to Measure Lung Permeability

NCT06105424
View directory record Official record
Conditions
Tobacco Use, Smoking, Smoking, Tobacco
Interventions
Lung Permeability Assessment
Procedure
Lead sponsor
RAI Services Company
Industry
Eligibility
30 Years to 50 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Sep 3, 2026, 6:55 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use Cigarettes, E-cigarettes and Cannabis (Co-Tox Study)

NCT07167225
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, E-Cig Use
Interventions
Effectiveness of different recruitment approaches, Choice of study completion locations, Cannabis Engagement Assessment, E-cigarette dependence Scale, Nicotine dependence Scale, Co use practices QUestionnaire
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 25 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Not applicable Interventional

Study on Sit to Quit Phone Intervention

NCT02840435
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Sit to Quit, Quit for Life
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 12, 2019 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Phase 1Phase 2 Interventional

The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence

NCT02590393
View directory record Official record
Conditions
Nicotine Dependence
Interventions
E-cigarettes
Combination Product
Lead sponsor
Duke University
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Not applicable Interventional

Electronic Cigarettes as a Harm Reduction Strategy Among People Living With HIV/AIDS

NCT04218708
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Nicotine patch and gum, Minnesota Nicotine Withdrawal Scale (MNWS), ASSIST (the Alcohol, Smoking and Substance Involvement Screening), Counseling, NIDA Standardized Research E-cigarettes (SREC)
Other · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 19, 2024 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes

NCT04038515
View directory record Official record
Conditions
Nicotine, E-liquid Flavors
Interventions
Nicotine 0 mg/mL, Nicotine 6 mg/mL, Nicotine 12 mg/mL, Nicotine 24 mg/mL, 'Menthol' flavor, 'Menthol/Mint' flavor, 'Green Apple' flavor, 'Watermelon' flavor, 'Unflavored'
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 30 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 4, 2024 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Not applicable Interventional

The Impact of Innovative Tax Proposals on Purchase Patterns

NCT05370313
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Market Price Condition (control), Tobacco Parity Tax Condition, Nicotine-Content Tax Condition, Harm-Reduction Tax Condition, Modified Risk Tobacco Product (MRTP) Tax Condition
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
285 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Buffalo, New York • Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Nicotine in Tobacco Smokers

NCT03651869
View directory record Official record
Conditions
Smoking, Tobacco, Smoking (Tobacco) Addiction
Interventions
Cigarette 1, Cigarette 2, Patch 1, Patch 2
Drug
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 12, 2023 · Synced Sep 3, 2026, 6:55 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Melanin and Dermal Uptake of Thirdhand Cigarette Smoke

NCT06020248
View directory record Official record
Conditions
Healthy
Interventions
Wear clothing that has been exposed to cigarette smoke for 3 hours.
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 50 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 3, 2026, 6:55 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Facilitating Smoking Cessation With Reduced Nicotine Cigarettes

NCT02796391
View directory record Official record
Conditions
Smoking Cessation
Interventions
Very Low Nicotine Content (VLNC) Cigarettes, One on One Counseling
Drug · Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 13, 2022 · Synced Sep 3, 2026, 6:55 PM EDT