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Showing 1–24 of 87 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Nicotine gum and lozenge Clear all
Recruiting Not applicable Interventional

E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness

NCT05815199
View directory record Official record
Conditions
Cigarette Smoking
Interventions
E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling, Ecological Momentary Intervention (EMI) Text Messaging
Other · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Not applicable Interventional Results available

Pharmacist Intervention to Improve Smoking Cessation

NCT06943287
View directory record Official record
Conditions
Smoking Cessation
Interventions
Pharmacist Intervention
Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 100 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 29, 2026, 8:23 PM EDT
Not yet recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

A Stepped Care Approach to Treating Tobacco Use in Rural Veterans

NCT04501016
View directory record Official record
Conditions
Tobacco Cessation
Interventions
Tailored behavioral counseling, Tobacco cessation pharmacotherapy
Behavioral · Drug
Lead sponsor
Iowa City Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 99 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 5, 2020 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smoking Cessation in Women With Gynecological Conditions

NCT01989923
View directory record Official record
Conditions
Cervical Dysplasia
Interventions
Nicotine Replacement Therapy, Electronic Cigarettes
Other · Device
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 29, 2026, 8:23 PM EDT
Terminated Not applicable Interventional Results available

Analysis of Aldehyde Biomarkers of Exposure and Host Response

NCT00482690
View directory record Official record
Conditions
Smoking Cessation
Interventions
nicotine polacrilex, nicotine transdermal system, nicotine inhaler
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Not applicable Interventional

Use of Technological Advances to Prevent Smoking Relapse Among Smokers With PTSD

NCT01990079
View directory record Official record
Conditions
PTSD, Smoking
Interventions
Bupropion, nicotine replacement therapy, Smoking cessation counseling, mobile contingency management, Stay Quit Coach
Drug · Other · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Not applicable Interventional

Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use

NCT04694846
View directory record Official record
Conditions
Lung Non-Small Cell Carcinoma, Head and Neck Squamous Cell Carcinoma
Interventions
Nicotine Replacement, Bupropion Hydrochloride Controlled-release, Varenicline, Tobacco Cessation Counseling, Questionnaire Administration, Quality of Life Assessment, Best Practice
Drug · Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Not applicable Interventional

Durham Housing Authority (DHA) Community Health Advisor (CHA) Smoking Cessation Project

NCT04114526
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicotine Replacement Therapy
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 11, 2020 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Phase 2Phase 3 Interventional Results available

CPT and Smoking Cessation

NCT01901848
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Smoking
Interventions
Cognitive Processing Therapy (CPT), Bupropion, nicotine replacement therapy (NRT), Integrated Care for Smoking Cessation (ICSC), smokefreeVET
Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Phase 2 Interventional

Clinical Study of Smoke-Break Liquid Cigarettes

NCT00715871
View directory record Official record
Conditions
Smoking
Interventions
Nicotine, Smoke-Break nicotine delivery device
Drug · Device
Lead sponsor
Smoke-Break, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
West Allis, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 18, 2014 · Synced Sep 29, 2026, 8:23 PM EDT
Active, not recruiting Phase 4 Interventional

C-Raven, a Virtual Tobacco Cessation Intervention in Residency Clinics

NCT07220356
View directory record Official record
Conditions
Tobacco Dependence
Interventions
C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker, Lung Cancer Screening
Behavioral · Drug · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Not applicable Interventional

Evaluating the Impact of Quitting Using Executive Function Strategy Training (QUEST) on Smoking Cessation in Homeless Young Adult Smokers

NCT06745154
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Biospecimen Collection, Cognitive Assessment, Interview, Nicotine Replacement, Smoking Cessation Intervention, Survey Administration, Tobacco Cessation Counseling
Procedure · Other · Drug + 1 more
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years to 24 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 19, 2024 · Synced Sep 29, 2026, 8:23 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Testing an MBI for Smoking Cessation and Alcohol Use Among Cancer Survivors

NCT07447635
View directory record Official record
Conditions
Smoking Cessation, Alcohol Use
Interventions
Mindfulness-Based Relapse Prevention for Smoking and Alcohol (MBRP-SA), Quitline Support
Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Phase 4 Interventional Results available

Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking

NCT02995915
View directory record Official record
Conditions
Smoking Cessation, Alcohol Drinking
Interventions
Nicotine Replacement Therapy, Bupropion, Cognitive Behavioral Treatment, Mobile Contingency Management, Mobile Monitoring
Other · Drug · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Not applicable Interventional

Mobile Contingency Management for Smoking Cessation in Returning US Veterans

NCT02513069
View directory record Official record
Conditions
Smoking, Veterans
Interventions
Nicotine gum, mobile contingency management, Telephone counseling, Nicotine patch, Nicotine lozenge, Smart phone, Carbon monoxide monitor
Other · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 20, 2020 · Synced Sep 29, 2026, 8:23 PM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Integrating Financial Coaching and Smoking Cessation Coaching

NCT05154669
View directory record Official record
Conditions
Smoking
Interventions
Financial counseling, Nicotine Replacement Therapy Agent - Patches, Nicotine Replacement Therapy Agent - Lozenges, Nicotine Replacement Therapy Agent - Gum
Other · Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 100 Years
Enrollment
602 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Provoked Craving Relief Study by NRT

NCT01476202
View directory record Official record
Conditions
Smoking Cessation
Interventions
nicotine
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 29, 2013 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Offering Proactive Tobacco Treatment

NCT01123967
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
proactive outreach (PRO), telephone counseling (TC), Nicotine replacement therapy (NRT), Usual care (UC)
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Enrollment
2,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Not applicable Interventional Results available

Mobile Contingency Management for Marijuana and Tobacco Cessation

NCT02869451
View directory record Official record
Conditions
Cigarette Smoking, Marijuana Abuse
Interventions
bupropion, transdermal nicotine patch, Nicotine polacrilex, nicotine lozenge, counseling for marijuana and smoking cessation, mobile contingency management
Drug · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2020 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Not applicable Interventional

Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings

NCT05030272
View directory record Official record
Conditions
Tobacco Use Disorder, Mental Illness, Recurring Major Depressive Disorder, Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Persistent Depressive Disorder
Interventions
Quit on the Go App (formerly "Learn to Quit " App), Brief advice, Nicotine patch, Smartphone coaching, Nicotine gum, Nicotine Lozenges
Device · Behavioral · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
343 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
3
States / cities
Buffalo, New York • Durham, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Health Effects of SLT, Cigarette Smoking, and New Tobacco Products

NCT00469079
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine gum and lozenge, Taboka, Camel Snus
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 70 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 31, 2019 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment

NCT04461288
View directory record Official record
Conditions
Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions
Social media-based education, counseling, and support, Nicotine replacement therapies (NRT), Gamification
Behavioral · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 20, 2022 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Phase 4 Interventional Results available

BREATHE 2 Clinic Stop-Smoking Treatment Outreach Study

NCT05683821
View directory record Official record
Conditions
Quitting Smoking, Smoking Cessation, Smoking, Cigarette
Interventions
Text message smoking treatment, Nicotine replacement therapy sampling, Wisconsin Tobacco QuitLine Referral, Referral to Primary Care Provider, BREATHE 2 Cessation Study, Additional modalities to learn about and request treatment
Behavioral · Drug · Combination Product
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
12,376 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 29, 2026, 8:23 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Preloading With Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts

NCT04994444
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Nicoderm CQ 21Mg/24Hr Transdermal System
Drug
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Sep 29, 2026, 8:23 PM EDT