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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:56 PM EST

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Showing 241–264 of 429 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Nicotine replacement Clear all

Conditions: Tobacco Use Disorder
Interventions: smoking cessation intervention, questionnaire administration, quality-of-life assessment, laboratory biomarker analysis, ecigarettes; Behavioral · Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 18 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2011
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Smoking Cessation, Smoking, Smoking Behaviors, Smoking Reduction, Smoking, Tobacco, Smoking, Cigarette, Hiv, HIV/AIDS
Interventions: Lumme mobile phone application, Standard of Care; Device · Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Alcoholism, Smoking
Interventions: nicotine replacement patch; Drug
Lead sponsor: Minneapolis Veterans Affairs Medical Center; Federal
Eligibility: 21 Years to 75 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2004
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Tobacco Use Cessation, Tobacco Use Disorder, Nicotine Dependence, Smokeless Tobacco Use
Interventions: QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT); Behavioral · Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Tobacco Use Cessation
Interventions: Nicotine patch, Varenicline, Nicotine metabolism, Genetically-informed lung cancer risk score, NCI "Clearing the Air"; Drug · Genetic · Behavioral
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Smoking Cessation, Social Stress
Interventions: Social Support, NRT Sampling; Behavioral · Drug
Lead sponsor: Jessica Burris; Other
Eligibility: 18 Years to 75 Years
Enrollment: 49 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Tobacco Smoking
Interventions: CBI-CHW, Standard Care; Behavioral · Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cigarette Smoking, Nicotine Dependence
Interventions: Coaching calls, Nicotine replacement therapy, Financial Incentives; Behavioral · Drug
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years and older
Enrollment: 165 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Nicotine Dependence, Tobacco Use
Interventions: Nicotine replacement therapy - Transdermal nicotine patch, Nicotine replacement therapy - Nicotine gum, Nicotine replacement therapy - Nicotine lozenge, Bupropion, Varenicline, Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum, Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge, Combination pharmacotherapy - Transdermal nicotine patch + bupropion, Tobacco quitline referral, Tailored behavioral intervention, Alcohol use risk reduction, Behavioral activation for depressive symptoms, Behavioral management of postcessation weight gain; Drug · Behavioral
Lead sponsor: Mark Vander Weg; Other
Eligibility: 18 Years to 99 Years
Enrollment: 411 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Smoking
Interventions: Brief computerized feedback, Resources only (control); Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years and older
Enrollment: 151 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Midlothian, Virginia

Conditions: Smoking Cessation
Interventions: Nicorette Gum, Nicoderm CQ, Smoking Quitline Referral, Behavioral Smoking Cessation Counseling; Drug · Other · Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older · Male only
Enrollment: 134 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Tobacco Use Disorder, Smoking
Interventions: Ariva Silver Wintergreen, Placebo Wintergreen; Other
Lead sponsor: Star Scientific, Inc; Industry
Eligibility: 23 Years to 72 Years
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 1
States / cities: Martinsburg, West Virginia

Conditions: Smoking Cessation
Interventions: Exenatide, NRT, Counseling, Placebo; Drug · Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 75 Years
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation
Interventions: NRT + QuitBuddy, NRT + QuitBuddy-Recall, Treatment as Usual; Other
Lead sponsor: Meharry Medical College; Other
Eligibility: 18 Years and older
Enrollment: 94 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Cigarette Smoking, Tobacco Use, Cigarette Smoking Behavior
Interventions: HRP Sampling period, NPL Sampling period; Other
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 21 Years and older
Enrollment: 472 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Substance Dependence
Interventions: GSK598809, Nicotine Replacement Transdermal Patch, Placebo; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 10
States / cities: DeLand, Florida • Pembroke Pines, Florida • Stockbridge, Georgia + 7 more

Conditions: Tobacco Use Disorder/Cigarette Smoking, HIV
Interventions: nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster; Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 794 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 5
States / cities: Bridgeport, Connecticut • New Haven, Connecticut • Jersey City, New Jersey + 2 more

Conditions: Nicotine Dependence, Schizophrenia
Interventions: NRT, Bupropion SR 150mg bid, Relapse Prevention-Oriented Cognitive Behavioral Therapy; Drug · Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Asthma
Interventions: Cessation Counseling; Behavioral
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: Not listed
Enrollment: 230 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Smoking Cessation
Interventions: Enhanced E-cigarette Coaching, Quitline treatment as usual; Behavioral
Lead sponsor: Consumer Wellness Solutions; Industry
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Tobacco Use Disorder
Interventions: Lower Nicotine Smokeless Tobacco Product, Behavioral Counseling; Other
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2004
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Tobacco Smoking
Interventions: Cognitive-Behavioral Smoking Cessation, Heart Rate Variability Biofeedback (HRVB), Transdermal Nicotine patch; Behavioral · Drug
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 21 Years to 50 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Smoking, Pregnancy
Interventions: Nicotine Replacement Therapy; Behavioral
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 21 Years and older · Female only
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2011
U.S. locations: 2
States / cities: Washington D.C., District of Columbia

Conditions: Smoking Cessation
Interventions: Intervention Arm; Behavioral
Lead sponsor: Friends Research Institute, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 406 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Search by objective public record fields.

Interest in Smokeless Tobacco Product as a Substitution for Cigarettes in Current Smokers

Smoking Cessation Pilot for People Living With HIV (PLWH)

Timing of Smoking Intervention in Alcohol Treatment (Nicotine Patch)

Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid

PRecision Interventions for SMoking in the SCCS

Consultation, Advice, and Tailored Support (CATS) for Cancer Survivors

Computer Delivered and Community Health Worker Supported Smoking Cessation Intervention

Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties

Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers

Brief Computerized Feedback for Smokers in Recovery

Smoking Cessation in Hispanic Construction Workers

A Pilot Study to Evaluate the Efficacy of Ariva® Silver Wintergreen, a Smoking Aversive Lozenge

Exenatide Once Weekly for Smoking Cessation

Smoking Relapse Prevention Via Just-in-Time-Adaptive Interventions

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

Relapse Prevention Study in Newly Abstinent Smokers

Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial

Extended Duration Nicotine Replacement Therapy and Bupropion in Smokers With Schizophrenia

Exploring a Cessation Intervention for Smokers

Enhanced E-cigarette Coaching Intervention for Dual Users of Cigarettes and E-cigarettes

Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use

Heart Rate Variability Biofeedback for Smoking Cessation

Effectiveness of Nicotine Replacement Therapy in Reducing the Risk of Nicotine Exposure in Pregnant Minority Smokers

Embedding Comprehensive Smoking Cessation Programs Into Community Clinics