Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:08 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 265–288 of 429 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Nicotine replacement Clear all

Conditions: Cigarette Smoking
Interventions: Smoking cessation guideline implementation; Behavioral
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years and older
Enrollment: 789 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 2
States / cities: Des Moines, Iowa • Iowa City, Iowa

Conditions: Smoking Cessation, Smoking Reduction, Smoking, Tobacco
Interventions: Cessation Intervention; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 99 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Use Disorder, Smoking
Interventions: Ariva® Silver Wintergreen, Silver Wintergreen; Other
Lead sponsor: Star Scientific, Inc; Industry
Eligibility: 23 Years to 72 Years
Enrollment: 111 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010
U.S. locations: 1
States / cities: Martinsburg, West Virginia

Conditions: Smoking Cessation, Obesity and Obesity-related Medical Conditions
Interventions: Electronic Cigarettes (EC), Nicotine replacement therapy (NRT); Other
Lead sponsor: Brown University; Other
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Attention Deficit Hyperactivity Disorder, Nicotine Dependence
Interventions: Transdermal Nicotine Patch, Lis-dexamphetamine (Vyvanse), Placebo; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cardiovascular Disease, Tobacco Use Disorder
Interventions: Nicotine replacement, Motivational counseling; Drug · Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 152 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2005
U.S. locations: 2
States / cities: Minneapolis, Minnesota

Conditions: Cigarette Smoking
Interventions: Smoking research cigarettes with or without NRT; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Cigarette Smoking
Interventions: Contingency Management, Standard of Care; Behavioral · Other
Lead sponsor: UConn Health; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: New Britain, Connecticut

Conditions: Cigarette Smoker, Current Every Day Smoker
Interventions: Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette, Laboratory Biomarker Analysis, Nicotine Replacement, Questionnaire Administration; Procedure · Drug · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 52 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Interventions: Cigarette, Nicotine Replacement, Questionnaire Administration, Survey Administration, Very Low Nicotine Content Cigarette, ECIG-Hi, ECIG-Lo; Drug · Other · Device
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 21 Years to 65 Years
Enrollment: 213 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smokeless Tobacco Use
Interventions: nicotine replacement therapy, placebo NRT; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older · Male only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 2
States / cities: Rochester, Minnesota • Eugene, Oregon

Conditions: Smoking Cessation, Harm Reduction
Interventions: Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product, BIDI e-cigarette, on!; Drug · Other
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Smoking, Smoking Cessation
Interventions: Nicotine Replacement Therapy (NRT) Sampling, Ask, Advise, Refer (physician brief advice); Other · Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 1,278 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Alcohol Drinking
Interventions: 21mg transdermal nicotine patch (Nicoderm CQ), 1mg nicotine nasal spray, placebo nasal spray; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2016
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking Cessation
Interventions: Brief Advice, Motivational Interviewing, Rate Reduction, Pharmacological, MI+RR; Behavioral · Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 903 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Smoking Cessation
Interventions: Mobile Contingency Management; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 64 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Smoking, Cigarette, Smoking Cessation
Interventions: Varenicline, Combination nicotine patch and nicotine mini-lozenge treatment, Monetary incentives for initiating treatment, Automated tailored outreach, Care management, Wisconsin Tobacco Quit Line referral, Primary care provider referral, Untailored outreach, Multiple smoking cessation coaching calls; Drug · Behavioral · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Smoking
Interventions: Nicotine gum - 2 mg and 4 mg, Nicotine lozenges - 2 mg and 4 mg, Nicotine inhaler (4 mg yield) - low and high "dosage" by frequency of puffing, Computer learning; Drug · Other
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 21 Years to 65 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: West Los Angeles, California

Conditions: Tobacco Use
Interventions: Nicotine Replacement Therapy, Counseling; Drug · Behavioral
Lead sponsor: Hennepin Healthcare Research Institute; Other
Eligibility: 18 Years to 64 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Smoking, Tobacco
Interventions: HaRTS-TRENDS, Standard Care (SC); Other
Lead sponsor: University of Washington; Other
Eligibility: 21 Years to 65 Years
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Asthma
Interventions: Fp MDPI, Placebo MDPI, Flovent Diskus, albuterol/salbutamol; Drug · Other
Lead sponsor: Teva Branded Pharmaceutical Products R&D, Inc.; Industry
Eligibility: 12 Years and older
Enrollment: 889 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 148
States / cities: Birmingham, Alabama • Homewood, Alabama • Goodyear, Arizona + 114 more

Conditions: Smoking Cessation, Smoking
Interventions: Standard Treatment (ST), Telephone Counseling, Quitline, Nicotine Replacement Therapy (NRT); Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 639 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation
Interventions: Project Quit stop smoking program, Nicotine patches 21 mg; Behavioral · Drug
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 767 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Nicotine Dependence
Interventions: Aerobic Exercise, Counseling, Nicotine patch; Behavioral · Drug
Lead sponsor: Jasper A. Smits; Other
Eligibility: 18 Years and older
Enrollment: 360 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2029
U.S. locations: 1
States / cities: Austin, Texas

Search by objective public record fields.

The Effectiveness of Smoking Cessation Guidelines in the Emergency Department

Tobacco Cessation in Public Housing

Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in Smokers

Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy

Attention Deficit Hyperactivity Disorder (ADHD) Smoking Cessation Study

Reduction of Smoking in Cardiac Disease Patients

Project 1, Study 2: The Combined Impact of Nicotine Replacement and Spectrum Cigarettes

Contingency Management for Smoking Cessation in the Homeless

Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs

Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers

A Pilot Study Evaluating Nicotine Lozenges and Self Help

Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT

Tobacco Intervention in Primary Care Treatment Opportunities for Providers

Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 1: Nicotine Replacement Therapy

Strategies to Promote Cessation in Smokers Who Are Not Ready To Quit

Mobile Contingency Management for Smoking Cessation (R01 Supplement) (PrevailGO)

Health Systems Reach Interventions Project

Nicotine Delivery Systems: Research & Treatment

Jail-Based Use of Smoking Cessation Treatment Study

Harm Reduction for Tobacco Smoking With Support of Tobacco-Replacing Electronic Nicotine Delivery Systems

A Study of the Effectiveness and Safety of Different Doses of Fluticasone Propionate Taken From a Dry Powder Inhaler (Puffer) in Adolescents and Adults Who Have Asthma That is Not Controlled by High Dose Inhaled Corticosteroid Asthma Medications

Reducing Tobacco Related Health Disparities

Project Quit: Positive vs. Negative Offers of an Online Stop Smoking Program

Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity.