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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:13 PM EST

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Showing 289–312 of 429 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Nicotine replacement Clear all

Conditions: Smoking Cessation
Interventions: Empowering Cessation for the ACS South; Other
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 100 Years
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Smoking Cessation
Interventions: LTQ; Combination Product
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cigarette Smoking, Smoking Cessation, Depression
Interventions: Treatment as Usual, Goal2Quit + NRT Sampling; Behavioral · Combination Product
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 164 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Use
Interventions: Personalized Smoking Cessation Facilitation Meetings, Personalized Smoking Cessation Pharmacotherapy, Personalized Text Messaging Support, SmokefreeVET, VA Quitline, Education about pharmacotherapy; Behavioral · Drug · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation, Electronic Cigarette Use, Cigarette Smoking
Interventions: Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Smoking
Interventions: Nicoderm C-Q Transdermal Product, Orientation session, Craving-to-Quit app, Two brief follow-up phone calls, Group MT sessions, Brief advice on quitting smoking, Self-help smoking cessation materials; Drug · Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 2
States / cities: Miami, Florida • Memphis, Tennessee

Conditions: Tobacco Use Disorder
Interventions: Nicotrol; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 40 Years to 79 Years · Female only
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1993 – 2000
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Schizophrenia, Schizoaffective Disorder
Interventions: bupropion, transdermal nicotine patch; Drug
Lead sponsor: North Suffolk Mental Health Association; Other
Eligibility: 18 Years to 70 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2005
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking Cessation, Depression, Anxiety, Nicotine Dependence, Gender Minority Stress
Interventions: PRIDE QUIT, Enhanced Treatment As Usual (ETAU); Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 3
States / cities: Boston, Massachusetts

Conditions: Smoking Cessation
Interventions: Take a Break as an augmentation to NRT-sampling in Motivation Phase, NRT and mHealth assessment tool without feedback; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 433 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 4
States / cities: Worcester, Massachusetts • Great Neck, New York

Conditions: Tobacco Use, Substance Use Disorders
Interventions: Switching to E-Cigarette, Quitting using Medication, Counseling; Behavioral · Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 4
States / cities: Charleston, South Carolina • Conway, South Carolina • Greenville, South Carolina + 1 more

Conditions: Tobacco Use Cessation
Interventions: Varenicline plus Motivational Interviewing counseling, Varenicline without counseling; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 428 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Smoking Cessation, Smoking, Tobacco
Interventions: SmokeFreeText, Path2Quit; Behavioral
Lead sponsor: Case Comprehensive Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 119 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Smoking Cessation
Interventions: Stepped-Care, Control; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Walnut Creek, California

Conditions: Cigarette Smoking
Interventions: Nicotine patch; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Alcoholism, Smoking
Interventions: nicotine replacement patch; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years and older
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Ends 2002
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Tobacco Use Disorder
Interventions: Behavioral and pharmacologic tobacco use intervention; Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Tobacco Use Disorder, Mental Illness, Recurring Major Depressive Disorder, Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Persistent Depressive Disorder
Interventions: Quit on the Go App (formerly "Learn to Quit " App), Brief advice, Nicotine patch, Smartphone coaching, Nicotine gum, Nicotine Lozenges; Device · Behavioral · Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 343 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 3
States / cities: Buffalo, New York • Durham, North Carolina • Winston-Salem, North Carolina

Conditions: PTSD, Smoking
Interventions: Bupropion, nicotine replacement therapy, Smoking cessation counseling, mobile contingency management, Stay Quit Coach; Drug · Other · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking, Cardiovascular Disease Risk
Interventions: Resistance Training (RT), Nicotine Replacement Therapy (NRT); Other · Biological
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 35 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Human Immunodeficiency Virus, Smoking
Interventions: Bupropion, Varenicline, Cognitive Behavioral Therapy, Nicotine Replacement Therapy, Relapse Prevention Text Messaging; Drug · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation
Interventions: placebo, varenicline tartrate, bupropion hydrochloride, Nicotine Replacement Therapy Patch; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 4,595 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2015
U.S. locations: 65
States / cities: Mobile, Alabama • Encino, California • Escondido, California + 54 more

Conditions: Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Pancreatic Cancer, Tobacco Use Disorder
Interventions: nicotine, varenicline, placebo; Drug · Other
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 120 Years
Enrollment: 315 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Schizophrenia, Cigarette Smoking
Interventions: Nicotine replacement therapy, Bupropion, cognitive-behavioral smoking cessation counseling, Mobile Contingency Management, Stay Quit Coach, SMS text messaging; Drug · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Search by objective public record fields.

Empowering Cessation ACS South Region

Developing and Pilot Testing a Remote Smoking Cessation Digital Therapeutic for Individuals With Serious Mental Illness

Goal2Quit + NRT Sampling

Tobacco Cessation Treatment Preferences Among Veteran Smokers

CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes

Mindfulness Based Smoking Cessation Among Cancer Survivors

Tobacco Cessation in Postmenopausal Women (Part II) - 2

Nicotine Replacement Therapy for Smoking Cessation in Schizophrenia

Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke

Take a Break (TAB): mHealth-assisted Skills Building Challenge for Unmotivated Smokers

STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking

Improving Varenicline Adherence and Outcomes in Homeless Smokers

Path2Quit Tobacco Intervention For African Americans

Interventions for Smoking Among Persons in Recovery

Effects of Smoking Environments on Brain Reactivity

Smoking Cessation in Alcoholism Treatment

Tobacco Use Intervention Among Radiation Oncology Patients

Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings

Use of Technological Advances to Prevent Smoking Relapse Among Smokers With PTSD

Effect of Resistance Training on Tobacco-Related Cardiovascular Disease Risk

Mobile Evidence-Based Smoking Cessation for Veterans Living With HIV (MESH)

Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.

Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking

Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia