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ClinicalTrials.gov public records Last synced Nov 15, 2026, 3:09 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 361–384 of 429 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Nicotine replacement Clear all

Conditions: Smoking Cessation, Diabetes Type 2
Interventions: Contingency Management, Usual Care smoking cessation; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 75 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Tobacco Cessation
Interventions: Motivational interviewing, Smoking cessation counseling, Navigation to smoking cessation resources, Social support; Behavioral
Lead sponsor: Boston University; Other
Eligibility: 18 Years to 79 Years
Enrollment: 330 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Tobacco Smoking
Interventions: Genetic Education Session, Nutrition Education Session; Behavioral
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years and older
Enrollment: 103 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Smoking Cessation
Interventions: Nicotine replacement therapy (NRT), CS-CBT intervention, Path2Quit, Relapse prevention program, SmokefreeTXT; Other · Behavioral
Lead sponsor: Case Comprehensive Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Lung Cancer
Interventions: Digital-based support, Traditional-based support + Nicotine replacement therapy (NRT); Behavioral
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Smoking Cessation
Interventions: Aggressive Therapy; Other
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years and older
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Staten Island, New York

Conditions: Smokeless Tobacco Cessation
Interventions: Commit® nicotine lozenges (4 mg) & self-help materials, Commit® nicotine lozenges (4 mg) & phone counseling & self-help materials, Phone counseling & self-help materials; Drug · Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 1,067 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Smoking Cessation, Cancer, Treatment-Related
Interventions: Varenicline, Bupropion, Long-acting nicotine replacement therapy, Low-intensity counseling, High-intensity counseling, No nicotine replacement therapy, Nicotine Replacement Products; Drug · Behavioral · Other
Lead sponsor: Joseph Valentino, MD; Other
Eligibility: 18 Years and older
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 3
States / cities: Bowling Green, Kentucky • Lexington, Kentucky • Owensboro, Kentucky

Conditions: Smoking Cessation
Interventions: nicotine patch, experimental use, nicotine patch, labeled use; Drug
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 701 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Tobacco Dependence
Interventions: Nicotine Spray, Placebo; Drug
Lead sponsor: McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 1,198 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 8
States / cities: Scottsdale, Arizona • Burbank, California • Chicago, Illinois + 5 more

Conditions: Smoking Cessation
Interventions: Integrated Smoking Cessation and Financial Counseling, Waitlist Integrated Smoking Cessation and Financial Counseling, Nicotine Replacement Therapy (NRT); Behavioral · Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 410 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Nicotine Addiction, E-Cig Use, Quitting Smoking
Interventions: Nicotine replacement therapy patch, Nicotine replacement therapy lozenge, Quit electronic cigarettes, Continue electronic cigarettes; Drug · Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years to 29 Years
Enrollment: 396 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Remote vs. In-Person, Remote Visits, In-person Visits
Interventions: Combination Nicotine Replacement Therapy (patch and lozenge); Drug
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 18 Years to 99 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Buffalo, New York • Philadelphia, Pennsylvania

Conditions: Smoking
Interventions: active nicotine gum, Standard behavioral therapy; Drug · Behavioral
Lead sponsor: Brian Primack; Other
Eligibility: 18 Years and older
Enrollment: 505 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Smoking, Nicotine Addiction, Surgery
Interventions: ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling, brief advice, brochure; Behavioral · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Disorder
Interventions: Nicotine polacrilex, Bupropion; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 50 Years and older
Enrollment: 403 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2001 – 2009
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Nicotine Dependence
Interventions: Nicotine Patch, Moclobemide; Drug
Lead sponsor: Jed E. Rose; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 3
States / cities: Charlotte, North Carolina • Durham, North Carolina • Winston-Salem, North Carolina

Conditions: Dual Use of Cigarettes and E-cigarettes
Interventions: Text- and web-based support, Nicotine Replacement Therapy (NRT, nicotine patch), Nicotine replacement therapy lozenge; Behavioral · Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 321 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Use Disorder, Tobacco Dependence
Interventions: Quitbuddy, Control, SDoH Augmentation, SDoH Control; Other
Lead sponsor: Bryan W. Heckman; Other
Eligibility: 21 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Cigarette Smoking Behavior, E-Cigarette Use
Interventions: E-cigarette, Nicotine replacement therapy (patch, gum), both arms, CO-contingent financial incentives, both arms, Cessation counseling; Other · Drug · Behavioral
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 21 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Cessation
Interventions: Best Practices Advisory (BPA), BPA + Enhanced Education; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking
Interventions: Proactive outreach, Usual care; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 1,938 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2018
U.S. locations: 4
States / cities: Tampa, Florida • Minneapolis, Minnesota • New York, New York + 1 more

Conditions: Smoking Cessation
Interventions: Nicotine patch, Nicotine gum, Medication Therapy Management; Drug · Behavioral
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Tobacco Use Cessation
Interventions: Nicoderm CQ 21Mg/24Hr Transdermal System; Drug
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older
Enrollment: 49 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Providence, Rhode Island

Search by objective public record fields.

Diabetes Smoking Cessation Incentives Study

Intervention Study to Increase Smoking Cessation Rates Among Public Housing Residents

Developing Genetic Education for Smoking Cessation

Innovations to Prevent Relapse Among Low-income African American Smokers

Beyond the Lung Cancer Diagnosis: Leveraging the Oncology Clinic Setting for Actively Smoking Family Members

Comparison of Conservative and Aggressive Smoking Cessation Treatment Strategies in a Vascular Surgery Office Practice

Nicotine Lozenges and Assisted Self-help for Smokeless Tobacco Cessation

Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment

Treatment of Smoking Lapses and Relapses

Study to Determine the Efficacy and Safety of a Novel Nicotine Replacement Therapy

Integrating Financial Management Counseling and Smoking Cessation Counseling to Reduce Health and Economic Disparities in Low-Income Immigrants

Quit Smoking Study for People Who Use E-Cigarettes

Remote vs. In-Person Study Evaluation (RISE) Trials: RISE Above Smoking (Trial 1 of 3)

Cessation in Non-Daily Smokers

The END Perioperative Smoking Pilot Study

Maintaining Nonsmoking: Older Smokers - 1

Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers

DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy

Equitable Smoking Relapse Prevention

Project E-Shift: A Harm Reduction Intervention for Chronically Unhoused Smokers.

An EPIC Based BPA to Enhance Quit Line Referral and Use

Proactive Outreach for Smokers in VA Mental Health

QuitAid Pilot Feasibility Trial

Preloading With Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts