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ClinicalTrials.gov public records Last synced Nov 15, 2026, 12:09 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 429 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Nicotine replacement Clear all

Conditions: Smoking Cessation, Alcohol Drinking
Interventions: Nicotine Replacement Therapy, Bupropion, Cognitive Behavioral Treatment, Mobile Contingency Management, Mobile Monitoring; Other · Drug · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation
Interventions: High intensity disease management, Low intensity disease management, Comparison group, Bupropion; Behavioral · Drug
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 750 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Chronic Diseases
Interventions: smoking cessation; Behavioral
Lead sponsor: National Institutes of Health (NIH); NIH
Eligibility: 18 Years to 80 Years
Enrollment: 443 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Cigarette Smoking
Interventions: Market Price Condition (control), Tobacco Parity Tax Condition, Nicotine-Content Tax Condition, Harm-Reduction Tax Condition, Modified Risk Tobacco Product (MRTP) Tax Condition; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 285 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 2
States / cities: Buffalo, New York • Roanoke, Virginia

Conditions: Smoking Cessation
Interventions: hypnotherapy, Nicotine; Behavioral · Drug
Lead sponsor: North Shore Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 164 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Salem, Massachusetts

Conditions: Smoking
Interventions: mTHS 2.2, mCC, NNS; Other
Lead sponsor: Philip Morris Products S.A.; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Smoking Cessation
Interventions: Treatment As Usual (TAU), Nicotine Replacement Therapies, Text Message Intervention (TMI); Other · Drug · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 203 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Alcoholism, Smoking
Interventions: naltrexone (Revia), nicotine replacement patch; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 50 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1998 – 2003
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation
Interventions: Counseling, combination NRT; Behavioral · Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Smoking Cessation
Interventions: Counselor-Initiated Tobacco Quit Line, Self-Paced Tobacco Quit Line; Other
Lead sponsor: St. Jude Children's Research Hospital; Other
Eligibility: 18 Years and older
Enrollment: 946 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Tobacco Cessation
Interventions: BecomeAnEx; Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking Cessation
Interventions: nicotine polacrilex, nicotine transdermal system, nicotine inhaler; Drug
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Smoking Cessation
Interventions: Self-help materials, nicotine patch, Counseling, Smartphone-delivered automated treatment; Behavioral · Drug · Other
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 99 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Schizophrenia, Schizoaffective Disorder, Smokers
Interventions: bupropion + nicotine patch + nicotine gum or lozenges, Placebo pill + placebo patch; Drug
Lead sponsor: North Suffolk Mental Health Association; Other
Eligibility: 18 Years to 70 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking Cessation
Interventions: Nicotine patch, Quitline Counseling Phone Calls, Counseling Sessions, Pathways to Freedom, Monetary Incentive; Drug · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 21 Years and older
Enrollment: 1,550 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 5
States / cities: Phoenix, Arizona • Indianapolis, Indiana • Kansas City, Kansas + 2 more

Conditions: Cigarette Smoking, Addiction, E Cig Use
Interventions: E cigarettes, Nicotine Replacement Therapy; Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Tobacco Use Cessation
Interventions: Standard Care, smoking cessation DVD, PTF DVD; Behavioral
Lead sponsor: Case Comprehensive Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 1,050 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Smoking Cessation
Interventions: Smoking cessation; Behavioral
Lead sponsor: Virtua Health, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Voorhees Township, New Jersey

Conditions: Smoking Cessation
Interventions: standard care, standard care plus contingency management; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 2
States / cities: New Haven, Connecticut

Conditions: Tobacco Use
Interventions: e-cigarette, Nicotine patch, Nicotine lozenge; Behavioral · Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: iCanQuit Smartphone App Smoking Cessation Program, Nicotine Gum, Nicotine Patch, Nicotine Lozenge, Survey Administration, Interview; Device · Drug · Other
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 854 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Tobacco Use Disorder, Homelessness
Interventions: Nicotine Patches, mobile contingency management (mCM), Smoking cessation counseling, Nicotine rescue method, Bupropion; Drug · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 133 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Tobacco Use Disorder
Interventions: Nicotine Lozenge, Behavioral Counseling; Drug · Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Tobacco-Related Carcinoma
Interventions: Behavioral Intervention, Informational Intervention, Nicotine Replacement, Telephone-Based Intervention; Behavioral · Other · Drug
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Buffalo, New York

Search by objective public record fields.

Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking

Disease Management for Smoking Cessation

Longitudinal Care: Smoking Reduction to Aid Cessation

The Impact of Innovative Tax Proposals on Purchase Patterns

Smoking Cessation After Hospitalization for a Cardiopulmonary Illness

Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 Menthol (THS 2.2 Menthol)

A Pilot Text Messaging Intervention to Reduce Smoking in Office-based Buprenorphine and Inpatient Detoxification Patients

Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch)

Nicotine Replacement Therapy (NRT) Sampling and Selection to Increase Medication Adherence

Efficacy of Tobacco Quitline for Cancer Survivors

Development of a Scalable Intervention to Improve Smoking Cessation in Persons With Serious Mental Illness

Analysis of Aldehyde Biomarkers of Exposure and Host Response

Smartphone-delivered Automated Video-assisted Smoking Treatment for People Living With HIV

Smoking Relapse Prevention in Schizophrenia

My Path to Quit Tobacco

Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder

Enhancing Quitline Services for African American Smokers

Effectiveness of Smoking Cessation Program in a Community Health System

Novel Treatments to Enhance Smoking Cessation Before Cancer Surgery: Effects on Smoking and Surgical Outcomes

Quit or Switch: E-cigarette Study

iCanQuit Smoking Cessation Among Hispanic Adults

Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers

Nicotine Lozenge to Reduce Smokeless Tobacco Use

Episodic Future Thinking and Future Thinking Priming for Smoking Cessation