Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 15, 2026, 12:18 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 429 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Nicotine replacement Clear all

Conditions: Tobacco Dependence
Interventions: Placebo, Nicotine; Drug
Lead sponsor: McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 257 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 19
States / cities: Muscle Shoals, Alabama • Oceanside, California • Griffin, Georgia + 16 more

Conditions: E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
Interventions: Nicotine Replacement Therapies, Brief Behavioral Counseling; Drug · Behavioral
Lead sponsor: West Virginia University; Other
Eligibility: 21 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Greenville, North Carolina • Morgantown, West Virginia

Conditions: Tobacco Use Disorder
Interventions: Nicotrol Inhaler; Drug
Lead sponsor: Hartford Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Smoking
Interventions: Cognitive Behavioral Counseling, Mobile Contingency Management, Bupropion, Transdermal nicotine patch, Nicotine polacrilex, Nicotine lozenge; Behavioral · Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Substance Abuse
Interventions: Nicotine Replacement Treatment (NRT), Brief Advice, Contingency Management, Non-Contingent Reinforcement; Drug · Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older
Enrollment: 340 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Nicotine Replacement, Questionnaire Administration, Electronic Cigarette; Drug · Other · Device
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 169 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation
Interventions: Transitional Tobacco Care Management (TTCM), eReferral to State Tobacco Quitline (QL), Nicotine replacement therapy; Behavioral · Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 1,416 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 3
States / cities: Boston, Massachusetts • Pittsburgh, Pennsylvania • Nashville, Tennessee

Conditions: Mental Illness
Interventions: TRIIUMPH Intervention; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 192 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Use Disorder, Smoking
Interventions: Ariva Silver Wintergreen, Ariva Wintergreen; Other
Lead sponsor: Star Scientific, Inc; Industry
Eligibility: 23 Years to 72 Years
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 1
States / cities: Martinsburg, West Virginia

Conditions: Smoking Cessation
Interventions: Non-flavored 2mg nicotine gum, Non-flavored 4mg nicotine gum, Mint-flavored 2mg nicotine gum, Mint-flavored 4mg nicotine gum, Non-flavored nicotine inhaler, Mint-flavored nicotine ihaler; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Smoking, Smoking Cessation, Adherence, Nicotine Dependence, Motivation
Interventions: Short Term Combination Nicotine Replacement Therapy (patch + gum), Long Term Combination Nicotine Replacement Therapy (patch + gum), Intensive Maintenance Counseling, Cognitive Medication Adherence Counseling (CAM), Electronic Medication Monitoring Device (the Helping Hand) + Feedback, Automated Adherence Prompting Phone Calls; Drug · Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 99 Years
Enrollment: 544 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Chronic Disease, Neoplasm, Cardiovascular Disease, Pulmonary Disease, Chronic Obstructive, Diabetes Mellitus, Hypertension
Interventions: Family-supported, Standard Telephone counseling; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 471 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Asthma, Incentives, Tobacco Smoking
Interventions: Incentive plan, Smoking cessation; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 2 Years to 12 Years
Enrollment: 147 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking Cessation
Interventions: Telephone counseling, Voucher, Nicotine patches; Behavioral · Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 3,706 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: San Diego, California

Conditions: Smoking
Interventions: Naltrexone Hydrochloride, Transdermal Nicotine; Drug
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 1998 – 2001
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Tobacco Use Cessation
Interventions: Counseling, Contingency management, Nicotine patches; Other · Behavioral · Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 103 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Smoking, Smoking Behaviors, Smoking Cessation
Interventions: Take a Break plus Nicotine replacement therapy (NRT) Sampling, The Comparison, Community Paramedicine Standard Plus Enhanced Implementation Program, Community Paramedicine Standard Implementation Program; Behavioral · Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 800 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Tobacco Use
Interventions: Patient navigation-based tobacco harm reduction intervention; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Smoking, Smoking Cessation
Interventions: Comprehensive Relapse Prevention Intervention, Standard Treatment Counseling, Nicotine Replacement Therapy (NRT); Behavioral · Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 100 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Schizoaffective Disorder, Schizophrenia, Affective Psychosis, Bipolar, Affective Disorders, Psychotic
Interventions: BTSCS, StSST; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 179 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Baltimore, Maryland

Conditions: Smoking, Smoking, Tobacco, Tobacco Use Disorder
Interventions: Smoking cessation counseling (Quitline), Smoking cessation pharmacotherapy (e.g, nicotine replacement therapy), Financial incentives; Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 182 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Tobacco Cessation
Interventions: BecomeAnEX, Usual Care; Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years and older
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: Quitting Smoking, Smoking Cessation, Smoking, Cigarette
Interventions: Text message smoking treatment, Nicotine replacement therapy sampling, Wisconsin Tobacco QuitLine Referral, Referral to Primary Care Provider, BREATHE 2 Cessation Study, Additional modalities to learn about and request treatment; Behavioral · Drug · Combination Product
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 12,376 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Vaping
Interventions: Social Media Intervention; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 13 Years to 21 Years
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: San Francisco, California

Search by objective public record fields.

Study to Determine if a New Nicotine Replacement Therapy Can Safely Help Smokers to Quit Smoking

Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use

Pilot Study of Nicotine Replacement for Smoking Cessation During Pregnancy

Smoking Treatment and Exercise Program for Underserved Populations (STEP UP)

Contingency Management for Smoking in Substance Abusers

Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes

Post-Discharge Smoking Cessation Strategies: Helping HAND 4

Trial of Integrated Smoking Cessation, Exercise and Weight Management in Serious Mental Illness: TRIUMPH

A Pilot Study to Evaluate the Efficacy and Safety of Ariva® Silver Wintergreen in Healthy Smokers

Evaluation of Cessation Preferences of Menthol Smoker

Evaluation of Treatments to Improve Smoking Cessation Medication Adherence

Family-supported Smoking Cessation for Chronically Ill Veterans

Financial Incentives to Reduce Pediatric Tobacco Smoke Exposures

Providing Free Nicotine Patches to Quitline Smokers

Naltrexone and Patch for Smokers

Low-Cost Contingency Management for Smoking Cessation

Take A Break - Rural

Patient Navigation-based Tobacco Harm Reduction Program Among Cancer Patients

Preventing Smoking Relapse After Total Joint Replacement Surgery

Smoking Cessation for Veterans With Severe and Persistent Mental Illness

Financial Incentives for Smoking Treatment

Pilot Testing a Digital Intervention to Improve Smoking Cessation in Persons With Serious Mental Illness

BREATHE 2 Clinic Stop-Smoking Treatment Outreach Study

Social Media Intervention to Stop Nicotine and Cannabis Vaping Among Adolescents