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ClinicalTrials.gov public records Last synced Nov 15, 2026, 12:54 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 73–96 of 429 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Nicotine replacement Clear all

Conditions: Smoking Cessation, Motivation
Interventions: Phoenix, NRT order button, Factoid; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years and older
Enrollment: 152 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Smoking, Tobacco Abstinence
Interventions: Smokefree TXT Program, nicotine replacement patches, Nicotine Replacement Gum, Faxed Referral CT Smokers Quitline; Other · Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking
Interventions: Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (.03 mg), Behavioral Activation, Supportive Counseling; Drug · Behavioral
Lead sponsor: Maggie M Sweitzer, PhD; Other
Eligibility: 18 Years to 55 Years
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking Cessation
Interventions: Contingency management, Nicotine replacement therapy, Varenicline, Additional behavioral support; Behavioral · Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Dependence, Smoking Cessation
Interventions: Nicotrol Inhaler, Placebo Inhaler; Drug
Lead sponsor: UConn Health; Other
Eligibility: 16 Years and older · Female only
Enrollment: 154 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 2
States / cities: Hartford, Connecticut • Springfield, Massachusetts

Conditions: Smoking, Smoking Cessation, Tobacco Smoking, Cigarette Smoking
Interventions: Varenicline 0.5 MG, Nicotine Replacement Therapy (NRT); Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 652 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Smoking Cessation
Interventions: Internet-All Nations Breath of Life (I-ANBL), Honoring the Gift of Heart Health, Nicotine gum, Patch, or Lozenge or Zyban® or Chantix®; Other · Drug
Lead sponsor: Won Choi, PhD, MPH; Other
Eligibility: 18 Years and older
Enrollment: 251 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 2
States / cities: Kansas City, Kansas • Pablo, Montana

Conditions: Smoking Reduction or Abstinence
Interventions: In vivo counseling, Standard Smoking Cessation Counseling; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 517 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Smoking, Smoking Cessation, HIV Infections
Interventions: Nicotine Replacement Therapy, Mindfulness Training Smoking Cessation Intervention, Contingency Management Smoking Cessation Intervention; Drug · Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Smoking Cessation
Interventions: Culturally-tailored Tobacco Treatment, Culturally-tailored Content Newsletters, Control Preference Scale, Active Content Newsletter or Passive Content Newsletter; Behavioral
Lead sponsor: Hackensack Meridian Health; Other
Eligibility: 18 Years to 69 Years · Female only
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Nutley, New Jersey

Conditions: Smokeless Tobacco Use
Interventions: nicotine replacement therapy (nicotine patches), placebo NRT; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 55 Years
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Smoking
Interventions: Counseling, Self-help guide, Pharmacotherapy, Genetic feedback, verbal, Genetic feedback, printed; Behavioral · Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 3
States / cities: Menlo Park, California • Stanford, California • Seattle, Washington

Conditions: Smoking Cessation, Cigarette Smoking, Schizophrenia, Psychotic Disorders, Major Depressive Disorder, Bipolar Disorder I, Bipolar II Disorder, Mental Illness
Interventions: Nicotine patch, Nicotine lozenge, Therapy, Information; Drug · Behavioral · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 65 Years
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Smoking Cessation
Interventions: Standard Care (SC), Intensive Counseling (IC); Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 303 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 3
States / cities: Boston, Massachusetts • New York, New York

Conditions: Smoking Cessation
Interventions: Phone-based Tobacco Treatment, Nicotine Replacement, and Stepped Care Intervention, E-Referral to the Tobacco Quitline; Behavioral
Lead sponsor: Georgetown University; Other
Eligibility: 50 Years to 80 Years
Enrollment: 1,188 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Smoking Cessation
Interventions: BTSCS; Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 75 Years
Enrollment: 219 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 3
States / cities: Baltimore, Maryland • Timonium, Maryland

Conditions: Smoking Cessation
Interventions: Progesterone (200 mgs BID), Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cigarette Smoking, Tobacco Smoking, Tobacco Use Disorder
Interventions: Sustained Care, Standard Care; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 1,359 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 3
States / cities: Boston, Massachusetts • Salem, Massachusetts • Pittsburgh, Pennsylvania

Conditions: Cigarette Smoking
Interventions: Extended Care Management, Standard Care; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 397 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Tobacco Use Disorder
Interventions: Bupropion; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 21 Years to 75 Years
Enrollment: 589 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2000 – 2006
U.S. locations: 1
States / cities: New York, New York

Conditions: Alcoholism, Smoking
Interventions: nicotine replacement patch, mood management; Drug · Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2003
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Smoking, Total Joint Arthroplasty
Interventions: Blood Draw; Diagnostic Test
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years to 99 Years
Enrollment: 1,200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Chronic Kidney Disease, Hypertension
Interventions: In-Person Patient Education, Commitment to Change, Blood pressure monitoring, Written Patient Education, Text-based reinforcement for CKD self-management, Community-based education session, reinforcement for self-management, Text-based reinforcement for general health self-management; Behavioral
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 70 Years
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Smoking Cessation
Interventions: CQSS2, NicoDerm CQ Patch; Drug
Lead sponsor: Chrono Therapeutics, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 220 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 5
States / cities: Mobile, Alabama • Tempe, Arizona • Lexington, Kentucky + 2 more

Search by objective public record fields.

Project Phoenix: Pilot Intervention for Smokers Who Are Not Ready to Quit Smoking

Texting to Promote Tobacco Abstinence in Emergency Department Smokers: A Pilot Study

Neuroimaging Reward, Behavioral Treatment, and Smoking Cessation

A Smoking Cessation Intervention for Yale Dining Employees

Nicotine Replacement for Smoking Cessation During Pregnancy

STARS (Smoking Treatment And Remote Sampling) Study

Web-based Smoking Cessation Program for Tribal College Students

In Vivo Experience With NRT to Increase Adherence and Smoking Abstinence

Testing Integrative Smoking Cessation for HIV Patients

Quit & Fit 2.0: Feasibility and Usability Testing

Highdose Nicotine Patch Therapy for Smokeless Tobacco Use

Behaviorally Enhanced Counseling on Nicotine Dependence (BEACON) Trial.

Treating Smokers With Mental Illness

Integrating Tobacco Treatment Into Cancer Care: A Randomized Controlled Comparative Effectiveness Trial

Tobacco Education and Lung Health Study (TEAL)

An Integrated Approach to Smoking Cessation in Severe Mental Illness (SMI)

Progesterone Augmentation of Nicotine Replacement Therapy Study

Comparative Effectiveness of Post-Discharge Strategies for Hospitalized Smokers

Smoking Interventions for Hospital Patients

Maintenance Treatment for Abstinent Smokers

Behavioral Counseling for Alcohol Dependent Smokers (Nicotine Patch)

The Impact of Smoking on Outcomes and Complications in Total Joint Arthroplasty: A Prospective Crossover Study

Intensive Patient Referral and Education Program Prior to Renal Replacement Therapy

Safety and Efficacy Study of the NRT CQSS2 System for Smoking Cessation in Treatment-Seeking Subjects