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ClinicalTrials.gov public records Last synced Nov 15, 2026, 12:59 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–120 of 429 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Nicotine replacement Clear all

Conditions: Smoking, Alcoholism
Interventions: Cognitive Behavior Therapy for alcohol and smoking cessation, Nicoderm CQ nicotine patch, Placebo gum, Nicotine gum - Nicorette®; Behavioral · Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2006
U.S. locations: 1
States / cities: Newington, Connecticut

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Bupropion Hydrochloride Controlled-release, Nicotine Replacement, Questionnaire Administration, Tobacco Cessation Counseling, Varenicline; Drug · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 2,010 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Tobacco Use Disorder
Interventions: Oral tobacco, Nicotine Gum; Other · Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 70 Years
Enrollment: 391 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Eugene, Oregon

Conditions: Smoking Cessation, Alcohol Use
Interventions: Mindfulness-Based Relapse Prevention for Smoking and Alcohol (MBRP-SA), Quitline Support; Behavioral
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 600 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Smoking, Homeless Persons
Interventions: Bupropion, Nicotine replacement therapy, Contingency Management; Drug · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Tobacco Dependence
Interventions: Brief Intervention, Extended Treatment, Usual Care; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 956 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 3
States / cities: Berkeley, California • San Francisco, California • Stanford, California

Conditions: Smoking Cessation, Tobacco Use Cessation, Tobacco Smoking
Interventions: Nicorette, Tobacco Quit-line, Brief Behavioral Counseling, Intensive Behavioral Counseling; Drug · Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 608 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Miami, Florida

Conditions: HIV/AIDS, Smoking Cessation, Tobacco Use Disorder
Interventions: Learn to Quit-HIV, QuitGuide, Nicotine patch, Smartphone coaching; Device · Behavioral · Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: HIV Infection, Tobacco-Related Carcinoma
Interventions: Computed Tomography, Smoking Cessation Intervention; Procedure · Behavioral
Lead sponsor: AIDS Malignancy Consortium; Network
Eligibility: 45 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 11
States / cities: La Jolla, California • Washington D.C., District of Columbia • Tampa, Florida + 7 more

Conditions: Nicotine Addiction, Smoking Cessation
Interventions: Nicotine polacrilex, STAM 1100mAh CE4 eGo Clearomizer; Drug · Other
Lead sponsor: Creighton University; Other
Eligibility: 19 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: ESCAPE Intervention+NRT, quitSTART Intervention+NRT, CTRL+NRT
Interventions: ESCAPE app + NRT, quiSTART app + NRT, Control (CTRL); Behavioral
Lead sponsor: University of Houston; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Smoking Cessation
Interventions: Treatment as Usual, QuitGuide, Smart-T; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years and older
Enrollment: 98 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Veteran, Smoking Cessation
Interventions: Abstinence Reinforcement Therapy (ART), Telephone Counseling and NRT; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 310 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Nicotine Dependence
Interventions: Aerobic exercise, Smoking Cessation Intervention; Behavioral
Lead sponsor: Jasper A. Smits; Other
Eligibility: 18 Years to 65 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Cervical Dysplasia
Interventions: Nicotine Replacement Therapy, Electronic Cigarettes; Other · Device
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Cigarette Smoking
Interventions: Ask-Advise-Refer, Nicotine Patch, 14 Mg/24 Hr Transdermal Film, Extended Release, Nicotine lozenge; Behavioral · Drug
Lead sponsor: Sandra Japuntich; Other
Eligibility: 18 Years and older
Enrollment: 1,239 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Airway Morbidity, Smoking Cessation, Nicotine Adverse Reaction, Smoking, Tobacco, Smoking, Cigarette
Interventions: Electronic cigarette use, Control regular cigarette smokers; Device · Other
Lead sponsor: Miami VA Healthcare System; Federal
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Tobacco Use Disorder
Interventions: Usual Care Group, Reduction Group; Drug · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 70 Years
Enrollment: 332 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Smoking Cessation
Interventions: ELEVATE enhancement to electronic health record (EHR) to improve cessation counseling offer, ELEVATE enhancement to electronic health record (EHR) to improve smoking cessation medication offer, Data Driven Feedback reports; Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 1,000,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Smoking, Smoking Cessation, Lung Cancer Screening, Smoking, Tobacco, Smoking Behaviors
Interventions: Escape, Standard Care; Other
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 55 Years to 77 Years
Enrollment: 153 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Smoking Cessation
Interventions: Financial Incentives (FI) and Nicotine Replacement Therapy (NRT); Behavioral
Lead sponsor: University of Vermont Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Smoking Cessation
Interventions: Motivational Interviewing (MI), Nicotine Replacement Therapy (NRT), Nicotine Lozenge, Message Framing, saliva sample; Behavioral · Drug · Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 50 Years to 80 Years
Enrollment: 807 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2027
U.S. locations: 18
States / cities: Los Angeles, California • Walnut Creek, California • La Grange, Georgia + 14 more

Conditions: Tobacco Use Cessation, Smoking Cessation, Smoking, Tobacco Use Disorder
Interventions: Brief Intervention with NRT Initiation; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 780 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Smoking
Interventions: Brief tobacco counseling; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 2,637 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2009
U.S. locations: 3
States / cities: Jackson, Mississippi • New York, New York • Eugene, Oregon

Search by objective public record fields.

Combination Nicotine Replacement for Alcoholic Smokers

Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial

Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine

Testing an MBI for Smoking Cessation and Alcohol Use Among Cancer Survivors

Contingency Management for Smoking Cessation in Homeless Smokers

Evaluation of Tobacco Treatment Strategies for Inpatient Psychiatry

Smoking Cessation Program in the Construction Sector

Learn to Quit-HIV Pilot Study

Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study

e-Cigarettes Versus NRT Gum for Smoking Cessation

Enhancing Smoking Cessation for African American People Everywhere

Clinical Trial of an Automated Smartphone Based Smoking Cessation Treatment

Abstinence Reinforcement Therapy (ART) for Rural Veteran Smokers

YMCA Exercise Intervention for Smoking Cessation Study

Smoking Cessation in Women With Gynecological Conditions

Free Samples for Health

Adverse Airway Effects From Tobacco and E-Cigarettes

Comparison Across Treatment Conditions to Reduce Smokeless Tobacco Use

Electronic Health Record-Enabled Evidence-Based Smoking Cessation Quality Improvement Implementation Program

Digitally Enhanced Smoking Cessation for High Risk Smokers

Remote Smoking Cessation in Hospitalized Cardiac Patients

Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites

Treating Low-Income Smokers in the Hospital Emergency Department

Tobacco Cessation Via Public Health Dental Clinics