Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:18 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 145–168 of 429 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Nicotine replacement Clear all

Conditions: Smoking, Smoking Cessation, Smoking, Tobacco, Opioid Use, Opioid Abuse
Interventions: Nicotine patch; Drug
Lead sponsor: University of Houston; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation
Interventions: Varenicline, Oral Nicotine Replacement Therapy (NRT), Medication Reminders, Tobacco Cessation Counseling; Drug · Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 65 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Cigarette Smoking, Nicotine Dependence
Interventions: Choose to Change, Enhanced usual care; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 190 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Cystic Fibrosis
Interventions: Tobacco Treatment Specialist (TTS) intervention; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 19 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Tobacco Use Disorder
Interventions: placebo, 2 mg nicotine polacrilex; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 16 Years to 50 Years · Female only
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2007
U.S. locations: 4
States / cities: Farmington, Connecticut • Hartford, Connecticut • New Britain, Connecticut + 1 more

Conditions: Smoking Cessation
Interventions: Android Wear smartwatch, Adaptive Treatment, Nicotine Patch, interviewing-based counseling; Behavioral · Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation, Mental Illness
Interventions: Smart-T Mental Health+ and NRT, QuitGuide + NRT; Combination Product
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 100 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2028
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Smoking Cessation
Interventions: Educational Video; Behavioral
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 75 Years
Enrollment: 94 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Tobacco Use Disorder
Interventions: Very low nicotine content (VLNC) cigarettes and nicotine replacement therapy (NRT), Reduce cigarettes per day (CPD) with nicotine replacement therapy (NRT); Other
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 74 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Nicotine Dependence
Interventions: Motivational Interviewing, Psychoeducation; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 61 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: StayQuit Intervention
Interventions: StayQuit; Behavioral
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Use Disorder
Interventions: active repetitive transcranial magnetic stimulation, sham repetitive transcranial magnetic stimulation, cognitive behavioral therapy for smoking cessation, nicotine replacement therapy; Device · Behavioral · Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Drug Addiction, Smoking Cessation
Interventions: Nicotine transdermal system, Nicotine containing cigarette, Placebo cigarette; Drug · Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Smoking
Interventions: CBME, Optional NRT; Behavioral · Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 14 Years to 21 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Tobacco Cessation, Peripheral Artery Disease
Interventions: Tobacco Treatment Research Program Standard Care; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 100 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Smoking Cessation, Tobacco Use Disorder
Interventions: Nicotine Replacement Therapies, Nicotine patch, Folic Acid; Drug · Dietary Supplement
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 13 Years to 18 Years
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2004
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Smoking, Cigarette, Smoking Cessation
Interventions: Smoking Cessation iPad Decision Aid Tool; Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 100 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Smoking Cessation
Interventions: Nicotine Patch, Telephone Counseling, Placebo, Self-Help Materials; Drug · Behavioral · Other
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 4,200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: San Diego, California

Conditions: Tobacco Smoking
Interventions: Cigarettes, E-Cigarette, Nicotine Gum or Lozenge; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 264 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 3
States / cities: Minneapolis, Minnesota • Buffalo, New York • Columbus, Ohio

Conditions: Smoking Cessation
Interventions: Nicotine nasal spray, Smoking cessation counseling; Drug · Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 15 Years to 18 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use Cessation, Second Hand Tobacco Smoke
Interventions: Smoking Cessation Intervention Bundle, Control Group: Quitline; Behavioral · Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: Up to 80 Years
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2022
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Smoking Cessation
Interventions: Telephone counseling, Nicotine patches, Incentive; Behavioral · Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 3,816 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: San Diego, California

Conditions: Current Smoker, Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma, Laryngeal Squamous Cell Carcinoma, Nasopharyngeal Carcinoma, Oral Cavity Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma
Interventions: Bupropion Hydrochloride, Laboratory Biomarker Analysis, Nicotine Replacement, Quality-of-Life Assessment, Questionnaire Administration, Varenicline; Drug · Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 2
States / cities: Winston-Salem, North Carolina • Charleston, South Carolina

Conditions: Tobacco Use Disorder
Interventions: Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion, Varenicline, Mobile Contingency Management, Clinic-Based Smoking Cessation Counseling; Behavioral · Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2030
U.S. locations: 1
States / cities: Durham, North Carolina

Search by objective public record fields.

Opioids and Smoking Cessation

Effectiveness of Combination Varenicline and Oral Nicotine Replacement Therapy (COMBO)

Reducing Tobacco Use Disparities Among Low-Income Adults

Clinical Effort Against Smoke Exposure in Cystic Fibrosis

Nicotine Replacement Treatment for Pregnant Smokers - 1

Using Machine Learning to Develop Just-in-Time Adaptive Interventions for Smoking Cessation

Mobile App for Smoking Cessation and Mental Health

New Strategies to Enhance Smoking Cessation

Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day

Motivational Interviewing Compared to Psychoeducation for Smoking Precontemplators With SMI

Helping Veterans With SMI "StayQuit" From Smoking After Inpatient Hospitalization

Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD

Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3

Youth Smoking Cessation: Therapy +/- "The Patch"

Onsite Tobacco Cessation Treatment for Patients With PAD

Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1

Feasibility of a Decision Aid for E-Cigarettes in Primary Care

Telephone Counseling and the Distribution of Nicotine Patches to Smokers

Methods Project 4: Clinical Trial - Amended

Nicotine Replacement and Counseling In Adolescents

Interventions to Help Smoking Parents of Inpatients Reduce Exposure (INSPIRE)

A Randomized Trial of Medi-Cal Beneficiaries Calling the California Smokers' Helpline

Bupropion Hydrochloride or Patient's Choice for Smoking Cessation in Patients With Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy

Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness