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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:26 PM EST

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Showing 169–192 of 429 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Nicotine replacement Clear all

Conditions: Smokeless Tobacco, Nicotine Dependence
Interventions: Tailored behavioral intervention, Behavioral activation for elevated depressive symptoms, Post-cessation weight gain management, Alcohol use risk reduction, Nicotine replacement therapy - transdermal nicotine patch, Nicotine replacement therapy - nicotine lozenge, Nicotine replacement therapy - nicotine gum, Bupropion sustained release, Varenicline, Combination nicotine replacement therapy, Combination nicotine replacement therapy + bupropion, Tobacco quit line, Educational materials; Behavioral · Drug
Lead sponsor: Mark Vander Weg; Federal
Eligibility: 18 Years to 99 Years
Enrollment: 123 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Tobacco Smoking
Interventions: Cognitive-Behavioral Smoking Cessation, Heart Rate Variability Biofeedback, Nicotine patch; Behavioral · Biological · Drug
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 21 Years to 50 Years
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Peer Recovery Coaching for TUD
Interventions: Dual NRT, PeerTTS; Drug · Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking Cessation
Interventions: Nicotine Replacement Therapy, Smoking Cessation Counseling; Drug · Behavioral
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 278 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 2
States / cities: Kansas City, Kansas • Kansas City, Missouri

Conditions: Nicotine Dependence
Interventions: Nicotine patch - transdermal, placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 60 Years
Enrollment: 127 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Nicotine Replacement, Questionnaire Administration, Vaping; Drug · Other · Device
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 1,500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Limited Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer, Stage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lung Cancer, Stage IIB Non-small Cell Lung Cancer, Stage IIIA Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer, Tobacco Use Disorder
Interventions: questionnaire administration, quality-of-life assessment, counseling intervention, internet-based intervention, telephone-based intervention, educational intervention, nicotine replacement therapy; Other · Procedure · Behavioral + 1 more
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Tobacco Use Cessation
Interventions: Nicotine patch, nicotine gum, nicotine nasal spray, nicotine inhaler, Varenicline or bupropion, Contingency Management; Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 323 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 4
States / cities: Bridgeport, Connecticut • New Haven, Connecticut • Brooklyn, New York + 1 more

Conditions: Tobacco Use Disorder, Smoking Cessation
Interventions: Nicotine Polacrilex Gum (2 mg), Cognitive Behavioral Group Therapy (CBGT); Drug · Behavioral
Lead sponsor: University of Hawaii; Other
Eligibility: 18 Years to 80 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Honolulu, Hawaii

Conditions: Cigarette Smoking
Interventions: Harm Reduction Tax - Normal Nicotine Cigarettes Available, Harm Reduction Tax - Normal Nicotine Cigarettes Not Available, Modified Risk Tobacco Product Tax - Normal Nicotine Cigarettes Available, Modified Risk Tobacco Product Tax - Normal Nicotine Cigarettes Not Available, Nicotine Content Tax - Normal Nicotine Cigarettes Available, Nicotine Content Tax - Normal Nicotine Cigarettes Not Available, Tobacco Parity Tax - Normal Nicotine Cigarettes Available, Tobacco Parity Tax - Normal Nicotine Cigarettes Not Available; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 316 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Buffalo, New York • Roanoke, Virginia

Conditions: Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions: Social media-based education, counseling, and support, Nicotine replacement therapies (NRT), Gamification; Behavioral · Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 121 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Initial Efficacy of Quit Line, Efficacy of Secondary Reengagement Intervention
Interventions: Rate reduction intervention, Recycling Group, Choice Group, Proactive QL; Behavioral
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 614 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Lackland Air Force Base, Texas

Conditions: Second Hand Tobacco Smoke, Nicotine Dependence
Interventions: Ask, Advise, Refer, Telebased tobacco counseling, Telebased nutrition counseling, Mobile phone smoking cessation application, Mobile phone nutrition application, Nicotine polacrilex; Behavioral · Device · Drug
Lead sponsor: Temple University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 396 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking
Interventions: transdermal nicotine replacement therapy; Drug
Lead sponsor: Duke University; Other
Eligibility: 21 Years and older
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Tobacco Smoking
Interventions: Nicotine Patch, E-cigarette; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 65 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Tobacco-Use Disorder, Schizophrenia, Psychotic Disorders
Interventions: bupropion SR, Cognitive Behavioral Group Therapy, nicotine replacement therapy; Drug · Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1998 – 2004
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Pancreatic Cancer, Tobacco Use Disorder
Interventions: telephone-based intervention, nicotine replacement therapy, informational intervention, internet-based intervention, questionnaire administration; Behavioral · Drug · Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 18 Years to 120 Years
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Bladder Cancer, Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer, Lymphoma, Prostate Cancer, Testicular Germ Cell Tumor, Tobacco Use Disorder, Unspecified Adult Solid Tumor, Protocol Specific
Interventions: nicotine, Usual Care; Drug · Behavioral
Lead sponsor: Eastern Cooperative Oncology Group; Network
Eligibility: 19 Years to 120 Years
Enrollment: 434 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 1990
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Smoking Cessation, Smoking Behaviors, Smoking, Tobacco, Smoking, Cigarette, Smoking (Tobacco) Addiction
Interventions: ACT Lung Health Intervention; Behavioral
Lead sponsor: Dana-Farber Cancer Institute; Other
Eligibility: 18 Years to 100 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Smoking, Veterans
Interventions: Nicotine gum, mobile contingency management, Telephone counseling, Nicotine patch, Nicotine lozenge, Smart phone, Carbon monoxide monitor; Other · Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 291 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Cigarette Smoking, Nicotine Dependence
Interventions: varenicline (Chantix), bupropion (Zyban), nicotine patches; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 2
States / cities: Durham, North Carolina • Raleigh, North Carolina

Conditions: Tobacco Use Cessation
Interventions: proactive outreach (PRO), telephone counseling (TC), Nicotine replacement therapy (NRT), Usual care (UC); Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 64 Years
Enrollment: 2,500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Smoking Cessation
Interventions: Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC), Treatment As Usual; Behavioral
Lead sponsor: Kristin Ashford; Other
Eligibility: 18 Years to 49 Years · Female only
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 2
States / cities: Lexington, Kentucky

Conditions: Asthma, Smoking Cessation
Interventions: PAM, PAM-Enhanced/Asthma Counseling Phone Calls, Follow-Up Phone Calls - Child Wellness Topic; Behavioral
Lead sponsor: The Miriam Hospital; Other
Eligibility: 18 Years and older
Enrollment: 573 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2011
U.S. locations: 5
States / cities: Fall River, Massachusetts • Pawtucket, Rhode Island • Providence, Rhode Island + 1 more

Search by objective public record fields.

Treating Smokeless Tobacco Use in Rural Veterans

Heart Rate Variability Biofeedback for Smoking Cessation Treatment

Peer Recovery Coaching for Tobacco Abstinence in People With Opioid Use Disorder

Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers

Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging

A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior

Enhanced Quitline Intervention in Smoking Cessation for Patients With Non-Metastatic Lung Cancer

A Smart Approach to Treating Tobacco Use Disorder in Persons Living With HIV

Quit-Smoking Study for Native Hawaiians

Effects of Tax Proposals and Cigarette Availability on Tobacco Purchasing

Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment

Enhancing the Efficacy of Smoking Quit Line in the Military (AFIII Renewal)

Babies Living Safe and Smokefree

Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment

E-cigarettes to Promote Smoking Reduction Among Individuals With Schizophrenia

Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke

Acceptability of Less Harmful Alternatives to Cigarettes

Physician-Initiated Stop-Smoking Program for Patients Receiving Treatment for Early-Stage Cancer

ACT Lung Health Intervention: Phase Two

Mobile Contingency Management for Smoking Cessation in Returning US Veterans

Tailored Smoking Cessation Treatment for LIVE FOR LIFE® Participants

Offering Proactive Tobacco Treatment

Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC): Reducing Tobacco Use Among Opioid Addicted Women

Sustaining Smoking Cessation in Smokers With Kids With Asthma