Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:36 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 193–216 of 429 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Nicotine replacement Clear all

Conditions: Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Pancreatic Cancer, Tobacco Use Disorder
Interventions: nicotine lozenge, nicotine patch; Drug
Lead sponsor: Fox Chase Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 642 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 10
States / cities: Washington D.C., District of Columbia • Miami Beach, Florida • Augusta, Georgia + 7 more

Conditions: Tobacco Use Cessation
Interventions: Nicotine lozenge, Nicotine gum, Nicotine patch, Maryland Quitline, John Hopkins Tobacco Treatment Clinic; Drug · Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Smoking, Tobacco
Interventions: MASP app + NRT, QuitGuide app + NRT; Other
Lead sponsor: University of Houston; Other
Eligibility: 18 Years and older
Enrollment: 227 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 2
States / cities: Oklahoma City, Oklahoma • Houston, Texas

Conditions: Smoking Cessation
Interventions: NRT, Web Guide, Tweet2Quit; Drug · Behavioral
Lead sponsor: University of California, Irvine; Other
Eligibility: 21 Years to 59 Years
Enrollment: 980 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2022
U.S. locations: 2
States / cities: Irvine, California • Stanford, California

Conditions: Nicotine Dependence
Interventions: Active Retraining, Sham Retraining, Active transcranial direct current stimulation (TDCS), Sham transcranial direct current stimulation (TDCS), Nicotine Replacement Therapy (Habitrol); Behavioral · Device · Drug
Lead sponsor: The Mind Research Network; Other
Eligibility: 18 Years to 60 Years
Enrollment: 86 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Smoking Cessation, Mood Tolerance, Mood Management, Nicotine Replacement Therapy
Interventions: Mood Tolearance, Mood Management, Nicotine Replacement therapy; Behavioral · Drug
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: Not listed
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Nicotine Dependence
Interventions: Ad Libitum Use followed by Instructed Use of the Inspire Device, Instructed Use followed by Ad Libitum Use of the Inspire Device, Smart-T Smoking Cessation App with the Inspire Device Condition, Smart-T Smoking Cessation App Without the Inspire Device Condition, Nicotine replacement therapy (NRT), Inspire Device; Device · Drug
Lead sponsor: University of Houston; Other
Eligibility: 18 Years and older
Enrollment: 132 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Smoking Cessation
Interventions: nicotine; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Sedentary Time, Frailty
Interventions: Continuous sedentary reduction intervention, Bouted sedentary reduction intervention; Behavioral
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 65 Years and older
Enrollment: 61 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: Nicotine Dependence
Interventions: Varenicline, Bupropion, Nicotine patches, Nicotine Inhaler; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 702 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 4
States / cities: Charlotte, North Carolina • Durham, North Carolina • Raleigh, North Carolina + 1 more

Conditions: Smoking, Bipolar Disorder
Interventions: Experimental plus Nicotine Replacement Therapy, Control plus Nicotine Replacement Therapy; Behavioral
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 4
States / cities: Palo Alto, California • Denver, Colorado • Bedford, Massachusetts + 1 more

Conditions: Tobacco Use Disorder
Interventions: EHR alert; Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Use, Smoking Cessation, Smoking Behaviors, Nicotine Dependence, Nicotine Withdrawal
Interventions: Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling; Drug · Behavioral
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 780 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Smoking Cessation, HIV
Interventions: Combination Therapy, Standard Care Intervention; Other
Lead sponsor: dr. maria miguez; Other
Eligibility: 18 Years and older
Enrollment: 488 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Smoking Cessation
Interventions: Mobile Contingency Management, Standard Care; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 100 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Smoking Cessation
Interventions: Nicotine Replacement Therapy; Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Lung Non-Small Cell Carcinoma, Head and Neck Squamous Cell Carcinoma
Interventions: Nicotine Replacement, Bupropion Hydrochloride Controlled-release, Varenicline, Tobacco Cessation Counseling, Questionnaire Administration, Quality of Life Assessment, Best Practice; Drug · Other
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania

Conditions: Tobacco Dependence
Interventions: ProChange ExpertSystem; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 360 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 3
States / cities: Menlo Park, California • San Francisco, California • San Rafael, California

Conditions: Tobacco Use Cessation
Interventions: Opt Out Treatment Program, Nicotine Replacement Therapy, Opt In Treatment Program; Behavioral · Drug
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Smoking Cessation, Overweight, Obesity
Interventions: Nicotine patch; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Addiction, Smoking Cessation
Interventions: Quit Center cessation program; Behavioral
Lead sponsor: Quit Center LLC; Industry
Eligibility: 18 Years and older
Enrollment: 371 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Naples, Florida

Conditions: Nicotine Dependence
Interventions: Nicotine gum and lozenge, Taboka, Camel Snus; Drug · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 70 Years
Enrollment: 130 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Nicotine Dependence
Interventions: Transdermal nicotine patch; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 525 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 2
States / cities: Chicago, Illinois • Philadelphia, Pennsylvania

Conditions: Nicotine Addiction
Interventions: Nicotine patch and gum, Minnesota Nicotine Withdrawal Scale (MNWS), ASSIST (the Alcohol, Smoking and Substance Involvement Screening), Counseling, NIDA Standardized Research E-cigarettes (SREC); Other · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: New York, New York

Search by objective public record fields.

Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking

Inpatient Smoking Cessation Pilot Program

Smoking, Stress, and Mobile Technology

Twitter-enabled Mobile Messaging for Smoking Relapse Prevention (Tweet2Quit)

TDCS and Cognitive Retraining to Augment Pharmacotherapy for the Treatment of Nicotine Dependence

Mood and Smoking: A Comparison of Smoking Cessation Treatments

Smart Olfaction App to Reduce Relapse

Provoked Craving Relief Study by NRT

The Sedentary to Active Rising to Thrive (START) Trial

Concurrent Bupropion / Varenicline for Smoking Cessation

Web-Delivered Acceptance & Commitment Therapy for Smokers With Bipolar Disorder

Nicotine Replacement Therapy Prescribing and Lung Cancer Screening in Hospitalized Patients

Overcoming Nicotine Dependence to Enable Quitting

Patch Study - Intervention for HIV Positive Smokers

Automated Mobile Contingency Management for Smoking Cessation: A Pilot RCT (SCC PREVAILgo)

Durham Housing Authority (DHA) Community Health Advisor (CHA) Smoking Cessation Project

Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use

Tobacco Treatment for Employable Californians, Total IMPACT Study

Changing the Default for Tobacco Treatment

Internet-Administered Smoking Cessation Treatment for Overweight and Obese Smokers

Evaluation of a Smoking Cessation Program for Long-Term Abstinence

Health Effects of SLT, Cigarette Smoking, and New Tobacco Products

An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence

Electronic Cigarettes as a Harm Reduction Strategy Among People Living With HIV/AIDS