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ClinicalTrials.gov public records Last synced Sep 30, 2026, 2:49 PM EDT

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Showing 25–48 of 247 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Nicotine replacement therapy patches Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Tobacco Treatment for Employable Californians, Total IMPACT Study

NCT02478697
View directory record Official record
Conditions
Tobacco Dependence
Interventions
ProChange ExpertSystem
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
3
States / cities
Menlo Park, California • San Francisco, California • San Rafael, California
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Sep 30, 2026, 2:49 PM EDT
Recruiting Not applicable Interventional

E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness

NCT05815199
View directory record Official record
Conditions
Cigarette Smoking
Interventions
E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling, Ecological Momentary Intervention (EMI) Text Messaging
Other · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Precision Pharmacotherapy Smoking Cessation Program

NCT04897607
View directory record Official record
Conditions
Smoking Cessation
Interventions
Standard Care, Precision pharmacotherapy
Behavioral
Lead sponsor
Christiana Care Health Services
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Mar 31, 2023 · Synced Sep 30, 2026, 2:49 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Smart Olfaction App to Reduce Relapse

NCT07007195
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Ad Libitum Use followed by Instructed Use of the Inspire Device, Instructed Use followed by Ad Libitum Use of the Inspire Device, Smart-T Smoking Cessation App with the Inspire Device Condition, Smart-T Smoking Cessation App Without the Inspire Device Condition, Nicotine replacement therapy (NRT), Inspire Device
Device · Drug
Lead sponsor
University of Houston
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 30, 2026, 2:49 PM EDT
Not yet recruiting Not applicable Interventional

Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness

NCT07714200
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion, Varenicline, Mobile Contingency Management, Clinic-Based Smoking Cessation Counseling
Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Phase 4 Interventional Results available

Testing C-Raven, a Virtual Tobacco Cessation Intervention, in the Community

NCT06289192
View directory record Official record
Conditions
Tobacco Dependence
Interventions
C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker, Lung Cancer Screening
Behavioral · Drug · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
3
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Preloading With Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts

NCT04994444
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Nicoderm CQ 21Mg/24Hr Transdermal System
Drug
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 6, 2025 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Phase 4 Interventional

Timing of Smoking Intervention in Alcohol Treatment (Nicotine Patch)

NCT00000444
View directory record Official record
Conditions
Alcoholism, Smoking
Interventions
nicotine replacement patch
Drug
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
21 Years to 75 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2004
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 11, 2011 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Not applicable Interventional Results available

Smoking Cessation Using Motivational Therapy and Varenicline

NCT00701896
View directory record Official record
Conditions
Smoking, HIV Infections
Interventions
Varenicline tartrate, Nicotine Replacement Therapy, Biological Control, Motivational Interview
Drug · Other · Behavioral
Lead sponsor
Philip Diaz
Other
Eligibility
18 Years and older
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 15, 2021 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Phase 2 Interventional Results available

Combination Bupropion / Varenicline for Smoking Cessation in Male Smokers

NCT01806779
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Chantix, Zyban, Nicotine patches
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
376 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
4
States / cities
Charlotte, North Carolina • Durham, North Carolina • Raleigh, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2016 · Synced Sep 30, 2026, 2:49 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid

NCT07694492
View directory record Official record
Conditions
Tobacco Use Cessation, Tobacco Use Disorder, Nicotine Dependence, Smokeless Tobacco Use
Interventions
QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT)
Behavioral · Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Sep 30, 2026, 2:49 PM EDT
Enrolling by invitation Phase 4 Interventional

Piloting Novel Interventional Strategies to Improve Nicotine Pouches as a Substitute for Smoking

NCT07625956
View directory record Official record
Conditions
Smoking ( Cigarette)
Interventions
Nicotine replacement therapy patches, Oral nicotine pouches
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Not applicable Interventional Results available

Smoking Treatment and Exercise Program for Underserved Populations (STEP UP)

NCT02873754
View directory record Official record
Conditions
Smoking
Interventions
Cognitive Behavioral Counseling, Mobile Contingency Management, Bupropion, Transdermal nicotine patch, Nicotine polacrilex, Nicotine lozenge
Behavioral · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2018 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Assessment of High Dose Transdermal Nicotine for Fast Metabolizers of Nicotine

NCT00956943
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicoderm CQ transdermal nicotine, placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 45 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 15, 2014 · Synced Sep 30, 2026, 2:49 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Comparison of Conservative and Aggressive Smoking Cessation Treatment Strategies in a Vascular Surgery Office Practice

NCT01850589
View directory record Official record
Conditions
Smoking Cessation
Interventions
Aggressive Therapy
Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Staten Island, New York
Source: ClinicalTrials.gov public record
Updated Aug 3, 2015 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Phase 4 Interventional Results available

Engagement With an Adaptive Mobile Health Smoking Cessation Intervention

NCT04020718
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Brief telephone advice plus tailored text messages, Mailed nicotine replacement therapy, Proactive telephone coaching
Behavioral · Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Treating Smokers With Mental Illness

NCT03822416
View directory record Official record
Conditions
Smoking Cessation, Cigarette Smoking, Schizophrenia, Psychotic Disorders, Major Depressive Disorder, Bipolar Disorder I, Bipolar II Disorder, Mental Illness
Interventions
Nicotine patch, Nicotine lozenge, Therapy, Information
Drug · Behavioral · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Not applicable Interventional

Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free

NCT05362318
View directory record Official record
Conditions
Smoking, Tobacco Use, Lung Cancer
Interventions
Nicotine patch and lozenges, Telephone counseling sessions, Access to a web-based video, Florida Tobacco Quitline
Drug · Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Heart Rate Variability Biofeedback for Smoking Cessation Treatment

NCT05224050
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Cognitive-Behavioral Smoking Cessation, Heart Rate Variability Biofeedback, Nicotine patch
Behavioral · Biological · Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
21 Years to 50 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 1, 2024 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Not applicable Interventional Results available

Varenicline and Motivational Advice for Smokers With Substance Use Disorders

NCT00756275
View directory record Official record
Conditions
Smoking Cessation, Nicotine Dependence
Interventions
Nicotine Replacement Treatment (NRT), varenicline, Behavioral counseling for smoking cessation
Drug · Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 75 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Sep 30, 2026, 2:49 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior

NCT06260683
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Nicotine Replacement, Questionnaire Administration, Vaping
Drug · Other · Device
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Phase 2 Interventional

Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment

NCT04634071
View directory record Official record
Conditions
Smoking Cessation, Cancer, Treatment-Related
Interventions
Varenicline, Bupropion, Long-acting nicotine replacement therapy, Low-intensity counseling, High-intensity counseling, No nicotine replacement therapy, Nicotine Replacement Products
Drug · Behavioral · Other
Lead sponsor
Joseph Valentino, MD
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
3
States / cities
Bowling Green, Kentucky • Lexington, Kentucky • Owensboro, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Sep 30, 2026, 2:49 PM EDT
Completed Phase 1 Interventional

Smoking Cessation and Sexual Health in Men

NCT00833404
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicotine transdermal patch
Drug
Lead sponsor
University of Texas at Austin
Other
Eligibility
23 Years to 60 Years · Male only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 12, 2011 · Synced Sep 30, 2026, 2:49 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Risk Perception Among Quitting Smokers

NCT00384696
View directory record Official record
Conditions
Smoking
Interventions
Nicotine Replacement Therapy, Questionnaire
Drug · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 65 Years
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 24, 2019 · Synced Sep 30, 2026, 2:49 PM EDT