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Conditions: Tobacco Dependence
Interventions: C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker, Lung Cancer Screening; Behavioral · Drug · Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 50 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Substance Use Disorders
Interventions: Technology Augmented Treatment for Screening, Brief Intervention, Referral, and Treatment (SBIRT); Behavioral
Lead sponsor: Washington State University; Other
Eligibility: 21 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Spokane Valley, Washington

Conditions: Colorectal Cancer, Early Onset Colorectal Cancer, Diet Habit, Risk Reduction
Interventions: Semi Quantitative Food Frequency Questionnaire (SQFFQ); Behavioral
Lead sponsor: San Raffaele University; Other
Eligibility: 18 Years to 49 Years
Enrollment: 2,300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2035
U.S. locations: 2
States / cities: Denver, Colorado • Chicago, Illinois

Conditions: Smoking, Smoking Cessation, Smoking Reduction, Smoking Behaviors
Interventions: Reduction (relocation and reduction of personal smoking) and cessation, Resident Endorsement; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 405 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: New York, New York

Conditions: Gestational Diabetes Mellitus, Gestational Diabetes Mellitus in Pregnancy, Insulin Resistance
Interventions: Acute exercises sessions with different exercise types and intensities; Behavioral
Lead sponsor: University of Central Arkansas; Other
Eligibility: 18 Years to 35 Years · Female only
Enrollment: 23 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Conway, Arkansas

Conditions: Cardiovascular Diseases
Interventions: ENRICH pilot intervention (full intervention), ENRICH pilot intervention (partial intervention: only diet and physical activity); Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 39 Years · Female only
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Smoking Cessation
Interventions: Mobile EX cessation support, DC Quitline Support, Device Control; Behavioral
Lead sponsor: Truth Initiative; Other
Eligibility: 18 Years and older
Enrollment: 803 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Cancer, Smoking, Tobacco Use, Nicotine Dependence
Interventions: Clinician Nudge, Patient Nudge; Other
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: Not listed
Enrollment: 2,146 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 3
States / cities: Lancaster, Pennsylvania • Philadelphia, Pennsylvania • West Chester, Pennsylvania

Conditions: Smoking Cessation, Cancer, Treatment-Related
Interventions: Varenicline, Bupropion, Long-acting nicotine replacement therapy, Low-intensity counseling, High-intensity counseling, No nicotine replacement therapy, Nicotine Replacement Products; Drug · Behavioral · Other
Lead sponsor: Joseph Valentino, MD; Other
Eligibility: 18 Years and older
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 3
States / cities: Bowling Green, Kentucky • Lexington, Kentucky • Owensboro, Kentucky

Conditions: Tobacco Use Cessation, Perioperative/Postoperative Complications, Tobacco Smoking
Interventions: Brief behavioral intervention, SMS Program; Behavioral · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Prenatal Alcohol Exposure, Prenatal Tobacco Exposure, Prenatal Marijuana Exposure
Interventions: Computer tablet-delivered C4H, Person-delivered C4H, Brief Advice; Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years to 44 Years · Female only
Enrollment: 219 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Nicotine Dependence
Interventions: Cognitive Behavioural Therapy, Contingency Management, Nicotine Transdermal Patch; Behavioral · Drug
Lead sponsor: Yale University; Other
Eligibility: 14 Years to 19 Years
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Use, Cigarette Smoking
Interventions: Sham rTMS, Active rTMS 10 Hz DLPFC; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 22 Years to 70 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Nicotine Dependence
Interventions: Juul Electronic cigarette, Very Low Nicotine Cigarettes, Active Nicotine Patch, Placebo Patch; Device · Other · Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 21 Years and older
Enrollment: 209 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 2
States / cities: Madison, Wisconsin • Milwaukee, Wisconsin

Conditions: Smoking, Smoking Cessation
Interventions: Tobacco Treatment; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 706 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Tobacco Use Disorder, Mental Illness, Recurring Major Depressive Disorder, Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Persistent Depressive Disorder
Interventions: Quit on the Go App (formerly "Learn to Quit " App), Brief advice, Nicotine patch, Smartphone coaching, Nicotine gum, Nicotine Lozenges; Device · Behavioral · Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 343 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 3
States / cities: Buffalo, New York • Durham, North Carolina • Winston-Salem, North Carolina

Conditions: Smoking, Tobacco
Interventions: Counseling, Nicotine patch, Community Resource; Behavioral · Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 50 Years to 80 Years
Enrollment: 642 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 6
States / cities: Boston, Massachusetts • Newton, Massachusetts • Oak Bluffs, Massachusetts + 1 more

Conditions: Pulmonary Sarcoidosis
Interventions: nicotine patch; Drug
Lead sponsor: Elliott Crouser MD; Other
Eligibility: 18 Years and older
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Tobacco Use, Cigarette Smoking
Interventions: Experimental Tobacco Marketplace Task; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Tobacco Dependence, Schizophrenia
Interventions: Sampling Research Cigarettes; Combination Product
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 60 Years
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: Chronic Obstructive Pulmonary Disease
Interventions: HEPA portable air filter, Sham Control/Active Comparator; Other
Lead sponsor: Intermountain Health Care, Inc.; Other
Eligibility: 40 Years and older
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Quitting Smoking, Smoking Cessation, Smoking, Cigarette
Interventions: Text message smoking treatment, Nicotine replacement therapy sampling, Wisconsin Tobacco QuitLine Referral, Referral to Primary Care Provider, BREATHE 2 Cessation Study, Additional modalities to learn about and request treatment; Behavioral · Drug · Combination Product
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 12,376 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Smoking
Interventions: Quit smoking, Nicotine patch, Placebo Patch; Behavioral · Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 147 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Tobacco Use Disorder, Smoking
Interventions: Ariva® Silver Wintergreen, Silver Wintergreen; Other
Lead sponsor: Star Scientific, Inc; Industry
Eligibility: 23 Years to 72 Years
Enrollment: 111 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010
U.S. locations: 1
States / cities: Martinsburg, West Virginia

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C-Raven, a Virtual Tobacco Cessation Intervention in Residency Clinics

Technologically-Augmented Referrals to Mitigate Addiction Consequences

Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer

Supporting Smoke-Free Policy Compliance in Public Housing

Prenatal Exercise and Glucose Regulation

Early Intervention to Promote Cardiovascular Health of Mothers and Children

Study of Mobile Phone Support for the DC Tobacco Quitline

Improving Tobacco Treatment Rates for Outpatient Cancer Patients Who Smoke

Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment

Short Messaging Service Program to Help Quit Smoking During Perioperative Period.

Choices4Health: Intervention to Prevent Substance-exposed Pregnancy

Enhancing a High School Based Smoking Cessation Program

RTMS Targets Neural Circuits for Smoking Cessation

Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use

Tobacco Treatment Outreach to Reduce Disparities for Primary Care Populations

Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings

Assessing the Integration of Tobacco Cessation Treatment Into Lung Cancer Screening (LCS)

Study of Nicotine Patches in Patients With Sarcoidosis

Assessing Tobacco Product Choice When the Cost of Menthol Cigarettes Increases

Cigarette Smoking in Smokers With and Without Schizophrenia

Indoor Air Quality and Respiratory Symptoms in Former Smokers

BREATHE 2 Clinic Stop-Smoking Treatment Outreach Study

Neurobiology of Nicotine and Non-nicotine Components of Tobacco Addiction

Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in Smokers