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ClinicalTrials.gov public records Last synced Oct 12, 2026, 4:38 PM EDT

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Showing 217–240 of 415 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: No analgesia Clear all
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Healthy Children and Virtual Reality Mediation of Simulated Pain

NCT06854991
View directory record Official record
Conditions
Acute Pain, Experimental Pain in Healthy Human Participants, Children, Adolescents
Interventions
Active VR-PAT, Passive VR-PAT, iPad
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
6 Years to 17 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 12, 2026, 4:38 PM EDT
Recruiting Phase 4 Interventional

Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients

NCT06201676
View directory record Official record
Conditions
Orthopaedic Trauma, Chronic Opioid Use
Interventions
Ketorolac Injection, Standard of Care (SOC) Multimodal Analgesia
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
458 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 12, 2026, 4:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Quadratus Lumborum Block for Analgesia Following Hip Arthroscopy

NCT03557125
View directory record Official record
Conditions
Surgery
Interventions
QL Block, Saline Skin Wheel
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Oct 12, 2026, 4:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of Doulas in Early Pregnancy Management

NCT02165540
View directory record Official record
Conditions
Uterine Evacuation
Interventions
Doula
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 8, 2016 · Synced Oct 12, 2026, 4:38 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0

NCT06725550
View directory record Official record
Conditions
Sickle Cell Disease, Pain, Acupuncture, Quantitative Sensory Testing, Magnetic Resonance Imaging, Circulating Biomarkers, Electroencephalography, Functional Near-infrared Spectroscopy
Interventions
needling acupuncture, laser acupuncture
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
14 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Oct 12, 2026, 4:38 PM EDT
Completed Not applicable Interventional

Improving Pain Management for Older Adults in the Emergency Department (ED)

NCT01962610
View directory record Official record
Conditions
Abdominal Pain Care
Interventions
ePCA and Pain keycept intervention
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
20 Years and older
Enrollment
4,693 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 5, 2015 · Synced Oct 12, 2026, 4:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Aromatherapy on the Incidence and Severity of Acute Pain

NCT03122574
View directory record Official record
Conditions
Venipuncture
Interventions
Lavender Aromatherapy, Jojoba Aromatherapy
Other
Lead sponsor
Children's National Research Institute
Other
Eligibility
7 Years to 11 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 21, 2017 · Synced Oct 12, 2026, 4:38 PM EDT
Recruiting Phase 4 Interventional

Efficacy of Methylprednisolone for Pain Control After ACL Repair

NCT07158476
View directory record Official record
Conditions
ACL Surgery, Pain Management
Interventions
Meloxicam 15 mg, Medrol 4 MG Oral Tablet Includes Medrol Dosepak, Gabapentin 300 mg, Hydrocodone 5Mg/Acetaminophen 325Mg Tab, Ketorolac 10 Mg Oral Tablet
Drug
Lead sponsor
St. Louis University
Other
Eligibility
13 Years to 50 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 24, 2025 · Synced Oct 12, 2026, 4:38 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Sevoflurane's Effect on Neurocognition Study

NCT06044740
View directory record Official record
Conditions
Anesthesia, Pain, Amnesia
Interventions
Sevoflurane, Peripheral Nerve Stimulation
Drug · Device
Lead sponsor
Keith M Vogt
Other
Eligibility
18 Years to 59 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 12, 2026, 4:38 PM EDT
Completed Not applicable Interventional Results available

iCanCope With Sickle Cell Pain

NCT03201874
View directory record Official record
Conditions
Sickle Cell Disease
Interventions
Pain self-management, Education
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
12 Years to 18 Years
Enrollment
137 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
3
States / cities
Hartford, Connecticut • Atlanta, Georgia • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 13, 2023 · Synced Oct 12, 2026, 4:38 PM EDT
Recruiting Not applicable Interventional

Gastric Emptying of Water and Sports Drink in Labor

NCT04229043
View directory record Official record
Conditions
Pregnancy, Gastric Emptying
Interventions
Sports drink, Water
Dietary Supplement
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Oct 12, 2026, 4:38 PM EDT
Withdrawn Not applicable Interventional

Pain Management in Children Undergoing Supracondylar Humerus Fracture Repair

NCT01812863
View directory record Official record
Conditions
Humeral Fractures, Fractures, Closed
Interventions
Supraclavicular nerve block
Procedure
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
2 Years to 10 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 7, 2018 · Synced Oct 12, 2026, 4:38 PM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine for Pain Control Following Anterior Cruciate Ligament Reconstruction

NCT02189317
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Exparel
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 27, 2016 · Synced Oct 12, 2026, 4:38 PM EDT
Completed Not applicable Interventional Results available

Tailored Non-Pharmacotherapy Services for Chronic Pain

NCT04523714
View directory record Official record
Conditions
Chronic Pain
Interventions
Online CBT-CP based program, Virtual health coach-led CBT-CP based program
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
2,333 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
4
States / cities
Atlanta, Georgia • Duluth, Minnesota • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 12, 2026, 4:38 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Can PLIA Reduce Early Post-operative Pain After PAO Surgery?

NCT06519955
View directory record Official record
Conditions
Hip Dysplasia
Interventions
Ropivacaine, Epinephrine, Ketorolac, NaCl (Saline)
Combination Product
Lead sponsor
Michael C Willey
Other
Eligibility
13 Years to 50 Years
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 12, 2026, 4:38 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Intrauterine Device Insertion Pain Management

NCT06951191
View directory record Official record
Conditions
IUD Insertion Pain, IUD Insertion
Interventions
Benzocaine 20%, Lidocaine 2%, Sham injection, Saline 0.9%
Drug · Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older · Female only
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Oct 12, 2026, 4:38 PM EDT
Completed Not applicable Interventional Results available

Lidocaine Analgesia for Urethral Catheterization in Children

NCT01780324
View directory record Official record
Conditions
Pediatric Presentation of Urinary Tract Infection
Interventions
Lidocaine
Drug
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Up to 3 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 11, 2016 · Synced Oct 12, 2026, 4:38 PM EDT
Not listed Phase 4 Interventional

Post Intravitreal Injection Topical NSAID vs. Patching

NCT03918590
View directory record Official record
Conditions
Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
Interventions
nepafenac 0.3% suspension (Ilevro; Alcon, Fort Worth, TX), Theratears tear drop, (Akron, Ann 111 Arbor, MI), patching
Drug · Other
Lead sponsor
The New York Eye & Ear Infirmary
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Oct 12, 2026, 4:38 PM EDT
Recruiting Not applicable Interventional

Impact of the NeuroCuple Device on Pain Management After Cesarean Delivery

NCT07185425
View directory record Official record
Conditions
Pain, Analgesia, Pregnancy
Interventions
NeuroCuple, Sham
Device
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years and older · Female only
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 16, 2025 · Synced Oct 12, 2026, 4:38 PM EDT
Completed Not applicable Interventional Results available

STandard Versus No Opioid Prescription After Prolapse and Anti-INcontinence Surgery Trial

NCT04491617
View directory record Official record
Conditions
Postoperative Pain, Opioid Use, Prolapse; Female, Incontinence
Interventions
Standard opioid prescribing, Restrictive opioid prescribing
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 24, 2025 · Synced Oct 12, 2026, 4:38 PM EDT
Completed Not applicable Interventional Results available

Transcutaneous Electrical Nerve Stimulation (TENS) and Fibromyalgia (FM)

NCT00932360
View directory record Official record
Conditions
Fibromyalgia
Interventions
TENS
Device
Lead sponsor
Dana Dailey
Other
Eligibility
18 Years to 90 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 16, 2019 · Synced Oct 12, 2026, 4:38 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Paracervical Block for Pain Control in First Trimester Abortion

NCT01094366
View directory record Official record
Conditions
Legal Abortion With Complication, Pain
Interventions
Paracervical Block, Sham Paracervical Block
Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 27, 2019 · Synced Oct 12, 2026, 4:38 PM EDT
Terminated Phase 3 Interventional Results available

Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy

NCT05172570
View directory record Official record
Conditions
Thoracotomy, Pain, Postoperative
Interventions
Gabapentin
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 21, 2024 · Synced Oct 12, 2026, 4:38 PM EDT
Terminated Not applicable Interventional

Assessing the Efficacy of Virtual Reality Analgesia (VRA) in Pediatric Patients for Pain Control

NCT03480724
View directory record Official record
Conditions
Pain
Interventions
Google Cardboard VRA, Oculus Rift VRA
Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
5 Years to 18 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jan 5, 2024 · Synced Oct 12, 2026, 4:38 PM EDT