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Showing 1–24 of 43 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: No contact lenses Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Neurolens and Contact Lens Discomfort

NCT05801991
View directory record Official record
Conditions
Contact Lens Discomfort
Interventions
Neurolens, Placebo spectacle lens
Device
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated Apr 21, 2025 · Synced Sep 25, 2026, 8:41 PM EDT
Active, not recruiting Not applicable Interventional

Evaluation of an Integrated Imaging System For In Vivo Detection of Fluorescently Labeled Lesions

NCT02802553
View directory record Official record
Conditions
Invasive Breast Cancer
Interventions
Smart Goggle, Cardio-Green, SPY Elite Imaging system, Quest near-infrared (NIR) Imaging system, PDE Imaging system, Gamma probe, Blue Dyes
Device · Other
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of a Scleral Lens on the Anterior Chamber Depth and Minimum Rim Width

NCT03926975
View directory record Official record
Conditions
Ocular Hypertension
Interventions
Scleral Lens, No lens
Device · Other
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 60 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Not applicable Interventional Results available

Treatment of Meibomian Gland Dysfunction and Dry Eye in Contact Lens Wearers

NCT02102464
View directory record Official record
Conditions
Meibomian Gland Dysfunction, Dry Eye
Interventions
LipiFlow treatment
Device
Lead sponsor
TearScience, Inc.
Industry
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
5
States / cities
Birmingham, Alabama • Morrow, Georgia • Charlotte, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 17, 2017 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Two Marketed Multifocal Contact Lenses

NCT03322423
View directory record Official record
Conditions
Visual Performance
Interventions
Multifocal Contact Lens 1, Multifocal Contact Lens 2, Spherical Contact Lens 2
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
5
States / cities
Sarasota, Florida • Albuquerque, New Mexico • Vestal, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2019 · Synced Sep 25, 2026, 8:41 PM EDT
Active, not recruiting Not applicable Interventional

Acuity 200™ (Fluoroxyfocon A) Orthokeratology Contact Lens for Overnight Wear

NCT06009458
View directory record Official record
Conditions
Myopia
Interventions
Acuity 200™ (fluoroxyfocon A) Orthokeratology Contact Lens for Overnight Wear
Device
Lead sponsor
Acuity Polymers, Inc.
Industry
Eligibility
7 Years and older
Enrollment
387 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
9
States / cities
Mission Viejo, California • Oakland, California • San Francisco, California + 6 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Two Approved Contact Lenses

NCT02759692
View directory record Official record
Conditions
Visual Acuity
Interventions
TEST Contact Lens, CONTROL Contact Lens
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 39 Years
Enrollment
283 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
13
States / cities
Montgomery, Alabama • Jacksonville, Florida • Sarasota, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Aug 17, 2017 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating and Improving Functional Driving Vision of Patients With Astigmatism

NCT02624791
View directory record Official record
Conditions
Astigmatism
Interventions
1-DAY ACUVUE® MOIST contact lenses, 1-DAY ACUVUE® MOIST for ASTIGMATISM contact lenses, No contact lenses
Device · Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 39 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 5, 2020 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Phase 3 Interventional

Evaluation of Efficacy and Safety of an Anti-Allergy Drug With a Contact Lens in the Treatment of Allergic Conjunctivitis

NCT00445874
View directory record Official record
Conditions
Allergic Conjunctivitis
Interventions
Ketotifen with a Contact Lens (no generic name)
Drug
Lead sponsor
Vistakon Pharmaceuticals
Industry
Eligibility
8 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
7
States / cities
Phoenix, Arizona • Irvine, California • North Andover, Massachusetts + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2009 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Phase 4 Interventional Results available

Evaluation of Systane Complete for the Treatment of Contact Lens Discomfort

NCT03682809
View directory record Official record
Conditions
Contact Lens Discomfort, Dry Eye
Interventions
Systane Complete
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
Birmingham, Alabama • Babylon, New York • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 5, 2020 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Fitting Investigational Contact Lenses

NCT03150485
View directory record Official record
Conditions
Visual Acuity
Interventions
JJVC Fitting Guides
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 28, 2018 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pilot Study on Ambulatory Intraocular Pressure and Blood Pressure Monitoring in Glaucoma

NCT01912599
View directory record Official record
Conditions
Normal-Tension Glaucoma
Interventions
Sensimed Triggerfish, Blood Pressure
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 16, 2016 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Characterization of Symptomatic Populations

NCT03319212
View directory record Official record
Conditions
Ametropia
Interventions
senofilcon A contact lenses
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 14, 2019 · Synced Sep 25, 2026, 8:41 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Meibomian Gland Probing in the Sub-Acute Phase of Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

NCT05145959
View directory record Official record
Conditions
Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses, Ocular Surface Disease, Meibomitis, Meibomian Gland Dysfunction, Dry Eye
Interventions
Maskin Probe
Device
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 5, 2021 · Synced Sep 25, 2026, 8:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparison of OCT and OCTA-based Ocular Measurements to Those of Predicate

NCT03852485
View directory record Official record
Conditions
Normal Eyes and Eyes With Ocular Pathologies
Interventions
SD-OCT
Device
Lead sponsor
Optovue
Industry
Eligibility
18 Years and older
Enrollment
199 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
2
States / cities
Newark, New Jersey • Marysville, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 2, 2019 · Synced Sep 25, 2026, 8:41 PM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Changes in Eye Shape With Myopia Management Interventions

NCT06450132
View directory record Official record
Conditions
Myopia
Interventions
Atropine Ophthalmic, MiSight 1-day disposable contact lenses
Drug · Device
Lead sponsor
Ohio State University
Other
Eligibility
21 Years to 30 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Phase 4 Interventional

Comfort and Cleaning Evaluation of Multipurpose Solutions in Contact Lens Patients

NCT00519948
View directory record Official record
Conditions
Patient Comfort, Lens Cleanliness
Interventions
new MPS, opti-free express no rub MPS
Drug
Lead sponsor
Innovative Medical
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Timeline
Ends 2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2008 · Synced Sep 25, 2026, 8:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Peripheral Defocus Profile of Multifocal Minus Contact Lenses

NCT06335212
View directory record Official record
Conditions
Myopia, Refractive Errors, Contact Lens
Interventions
Single vision and multifocal contact lenses
Device
Lead sponsor
State University of New York College of Optometry
Other
Eligibility
18 Years to 30 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 27, 2024 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Phase 4 Interventional Results available

Direct Application of Systane Complete to Contact Lenses

NCT03848221
View directory record Official record
Conditions
Dry Eye, Contact Lens Complication
Interventions
Systane Complete, Sensitive Eyes Rewetting Drops
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
3
States / cities
Birmingham, Alabama • Babylon, New York • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Evaluation of Miebo (Perfluorohexyloctane) Eyedrops in Habitual Contact Lens Wearers

NCT06176651
View directory record Official record
Conditions
Dry Eye, Dry Eye, Evaporative, Dry Eye Disease, Evaporative Dry Eye, Evaporative Dry Eye Disease, Kerato Conjunctivitis Sicca
Interventions
Miebo
Drug
Lead sponsor
Gordon Schanzlin New Vision
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2024 · Synced Sep 25, 2026, 8:41 PM EDT
Completed No phase listed Observational

A Retrospective Analysis of Restasis® Benefits in Dry Eye Contact Lens Patients

NCT02522312
View directory record Official record
Conditions
Dry Eye Syndrome
Interventions
No Intervention
Other
Lead sponsor
Hazleton Eye Specialists
Other
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Hazleton, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 2, 2016 · Synced Sep 25, 2026, 8:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

24-hour Wear Performance and Safety Study of Smartlens miLens Contact Lens for IOP Monitoring

NCT06689696
View directory record Official record
Conditions
Glaucoma, GLAUCOMA 1, OPEN ANGLE, D (Disorder), Ocular Hypertension, Ocular Hypertension (OH), Ocular Hypertension Glaucoma, IOP, Intraocular Pressure, Glaucoma Open-Angle, Glaucoma and Ocular Hypertension, Glaucoma Patients and Healthy Controls, Normal Tension Glaucoma (NTG)
Interventions
miLens system
Device
Lead sponsor
Smartlens, Inc.
Industry
Eligibility
22 Years to 80 Years
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
3
States / cities
Fullerton, California • Petaluma, California • Torrance, California
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Sep 25, 2026, 8:41 PM EDT
Terminated Phase 1 Interventional

Latanoprost Eluting Contact Lens for Treating Glaucoma and Ocular Hypertension

NCT04500574
View directory record Official record
Conditions
Glaucoma, Ocular Hypertension
Interventions
Latanoprost eluting contact lens, Topical Latanoprost
Drug
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years to 85 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Sep 25, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of an Investigational Multi-Purpose Disinfecting Solution for Care of Soft Contact Lenses

NCT00382681
View directory record Official record
Conditions
Contact Lens Care
Interventions
FID 107027 Multi-Purpose Disinfecting Solution, ReNu MultiPlus Multi-Purpose Solution No Rub Formula
Device
Lead sponsor
Alcon Research
Industry
Eligibility
Not listed
Enrollment
252 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004
U.S. locations
1
States / cities
Elkin, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 1, 2012 · Synced Sep 25, 2026, 8:41 PM EDT