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ClinicalTrials.gov public records Last synced Oct 25, 2026, 1:28 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–22 of 22 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Non-Contact Lens Wear Clear all
Completed No phase listed Observational Accepts healthy volunteers

Precision of OCT and OCTA-based Ocular Measurements

NCT03859310
View directory record Official record
Conditions
Normal Eyes and Ocular Pathology
Interventions
SD-OCT
Device
Lead sponsor
Optovue
Industry
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Marysville, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Oct 25, 2026, 1:28 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Study to Evaluate the Clinical Performance of SynergEyes A2 Hybrid Contact Lenses

NCT01058629
View directory record Official record
Conditions
Refractive Errors, Astigmatism
Interventions
SynergEyes A2 Hybrid Contact Lens
Device
Lead sponsor
SynergEyes, Inc.
Industry
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
10
States / cities
Campbell, California • Carlsbad, California • Encino, California + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2010 · Synced Oct 25, 2026, 1:28 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Delefilcon A Contact Lenses

NCT06884202
View directory record Official record
Conditions
Refractive Errors, Myopia
Interventions
Delefilcon A contact lenses with different base curves and diameters, Delefilcon A contact lenses with standard base curves and diameters
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
267 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
16
States / cities
Los Angeles, California • Oakland, California • San Francisco, California + 13 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 25, 2026, 1:28 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Corneal Epithelial Thickness Mapping

NCT01712022
View directory record Official record
Conditions
Dry Eye and Contact Lens Wear
Interventions
Not listed
Lead sponsor
Optovue
Industry
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
3
States / cities
Palo Alto, California • San Diego, California • Latham, New York
Source: ClinicalTrials.gov public record
Updated Sep 11, 2014 · Synced Oct 25, 2026, 1:28 PM EDT
Completed No phase listed Observational

Air Optix Night and Day Aqua (AONDA) Retrospective Study 1

NCT05790928
View directory record Official record
Conditions
Refractive Ametropia, Hyperopia, Myopia
Interventions
Lotrafilcon A spherical contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
108 participants
Timeline
2023
U.S. locations
4
States / cities
Tallahassee, Florida • Franklin Park, Illinois • Eden Prairie, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated May 25, 2023 · Synced Oct 25, 2026, 1:28 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Cosmetic Contact Lenses Post-Market Clinical Follow-up Study

NCT06517316
View directory record Official record
Conditions
Cosmetic Appearance
Interventions
Nelfilcon A plano cosmetic contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
12 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Oct 25, 2026, 1:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Controlling Myopia Progression With Soft Contact Lenses (Contact Lens Control)

NCT01829191
View directory record Official record
Conditions
Myopia
Interventions
Soft Contact Test Lens A, Soft Contact Test Lens C
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
8 Years to 12 Years
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 19, 2018 · Synced Oct 25, 2026, 1:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of a Scleral Lens on the Anterior Chamber Depth and Minimum Rim Width

NCT03926975
View directory record Official record
Conditions
Ocular Hypertension
Interventions
Scleral Lens, No lens
Device · Other
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 60 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 29, 2021 · Synced Oct 25, 2026, 1:28 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Visual Performance With Contact Lenses

NCT03705130
View directory record Official record
Conditions
Myopia
Interventions
Single Vision Contact Lens, Multifocal Contact Lens 1, Multifocal Contact Lens 2
Device
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 39 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Oct 25, 2026, 1:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pilot Study on Ambulatory Intraocular Pressure and Blood Pressure Monitoring in Glaucoma

NCT01912599
View directory record Official record
Conditions
Normal-Tension Glaucoma
Interventions
Sensimed Triggerfish, Blood Pressure
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 80 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2016 · Synced Oct 25, 2026, 1:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Treating Contact Lens Discomfort With Orthokeratology

NCT03566680
View directory record Official record
Conditions
Dry Eye, Contact Lens Complication
Interventions
Orthokeratology
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 45 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 17, 2020 · Synced Oct 25, 2026, 1:28 PM EDT
Recruiting No phase listed Observational

Agreement of Two OCT Biometers: A Pilot Study

NCT07782619
View directory record Official record
Conditions
Anterior Segment of Eye, Axial Length, Biometrics Measurement
Interventions
UNITY DX, ANTERION
Device
Lead sponsor
Alcon Research
Industry
Eligibility
21 Years and older
Enrollment
50 participants
Timeline
2026 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 25, 2026, 1:28 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers Results available

Tear Evaluation Between Habitual Contact Lens Wearers and Non Contact Lens Wearers

NCT01317030
View directory record Official record
Conditions
Dry Eye
Interventions
Contact Lens Wear, Non-Contact Lens Wear
Device · Other
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2020 · Synced Oct 25, 2026, 1:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Corneal Staining and Physiological Compromise After Eight Hours of Soft Contact Lens Wear

NCT01015768
View directory record Official record
Conditions
Contact Lens-induced Corneal Fluorescein Staining
Interventions
ReNu Multiplus multipurpose disinfecting solution, Control
Device
Lead sponsor
Southern California College of Optometry at Marshall B. Ketchum University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2020 · Synced Oct 25, 2026, 1:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing the Performance of 1 Day Multifocal Contact Lenses

NCT04449263
View directory record Official record
Conditions
Presbyopia
Interventions
Lens A, Lens B, Habitual Lenses
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
42 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
5
States / cities
San Diego, California • Whittier, California • Sarasota, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2021 · Synced Oct 25, 2026, 1:28 PM EDT
Terminated Not applicable Interventional Results available

Intraocular Pressure in Ocular Hypertensives With Scleral Lens Wear

NCT04442464
View directory record Official record
Conditions
Ocular Hypertension
Interventions
Scleral Lens
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 29, 2024 · Synced Oct 25, 2026, 1:28 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

UNITY DX Cornea Study

NCT07768735
View directory record Official record
Conditions
Tomography
Interventions
UNITY DX, ANTERION
Device
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 25, 2026, 1:28 PM EDT
Completed Not applicable Interventional Results available

Proclear 1-D Multifocal Nondispensing Study

NCT01526902
View directory record Official record
Conditions
Presbyopia
Interventions
omafilcon A / PC 1-D MF, lotrafilcon B / Air Optix MF
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
40 Years to 65 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 7, 2014 · Synced Oct 25, 2026, 1:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety and Effectiveness of the Qualis Contact Lens

NCT04295499
View directory record Official record
Conditions
Refractive Errors
Interventions
soft (hydrophilic) contact lens
Device
Lead sponsor
Unicon Optical Co. Ltd.
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
3
States / cities
Honolulu, Hawaii • New York, New York • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 19, 2023 · Synced Oct 25, 2026, 1:28 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft

NCT02592330
View directory record Official record
Conditions
Limbal Stem Cell Deficiency
Interventions
Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
Procedure · Biological
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years to 89 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 15, 2025 · Synced Oct 25, 2026, 1:28 PM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of a Daily Wear Silicone Hydrogel Lens

NCT04207749
View directory record Official record
Conditions
Refractive Errors, Myopia, Hyperopia
Interventions
LID015385 contact lenses, Comfilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
18
States / cities
Glendale, Arizona • Brentwood, California • Irvine, California + 15 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2022 · Synced Oct 25, 2026, 1:28 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparison of OCT and OCTA-based Ocular Measurements to Those of Predicate

NCT03852485
View directory record Official record
Conditions
Normal Eyes and Eyes With Ocular Pathologies
Interventions
SD-OCT
Device
Lead sponsor
Optovue
Industry
Eligibility
18 Years and older
Enrollment
199 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
2
States / cities
Newark, New Jersey • Marysville, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Oct 25, 2026, 1:28 PM EDT