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ClinicalTrials.gov public records Last synced Oct 24, 2026, 3:05 AM EDT

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Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Non-thrust manipulation Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Assessment of Chiropractic Treatment: Strength and Balance

NCT02670148
View directory record Official record
Conditions
Low Back Pain
Interventions
Chiropractic manipulative therapy
Procedure
Lead sponsor
Ian Coulter
Other
Eligibility
18 Years to 40 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Pensacola, Florida
Source: ClinicalTrials.gov public record
Updated Mar 28, 2019 · Synced Oct 24, 2026, 3:05 AM EDT
Not listed Not applicable Interventional

Effect of Lumbar Manipulation on Intervertebral Motion, Pain, and Disability

NCT06294132
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Manipulation, Sham Lumbar Manipulation
Procedure
Lead sponsor
Ithaca College
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated Mar 8, 2024 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Joint Mobilization in the Treatment of Chronic Ankle Instability

NCT01438905
View directory record Official record
Conditions
Ankle Sprain
Interventions
Small amplitude (Grade IV) mobilization, High velocity, low amplitude (Grade V) mobilization
Other
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 45 Years · Male only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 23, 2018 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional

Using fMRI to Determine if Cerebral Hemodynamic Responses to Pain Change Following Thoracic Spine Manipulation in Individuals With Mechanical Neck Pain

NCT01862705
View directory record Official record
Conditions
Neck Pain
Interventions
Thoracic spine manipulation
Other
Lead sponsor
OSF Healthcare System
Other
Eligibility
18 Years to 60 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated May 13, 2015 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional

ED Physical Therapy for Chronic Low Back Pain

NCT05206630
View directory record Official record
Conditions
Low Back Pain
Interventions
ED Physical Therapy
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 24, 2026, 3:05 AM EDT
Not listed No phase listed Observational

Applying Pain Adaptability to Manual Therapy Practice

NCT05209659
View directory record Official record
Conditions
Musculoskeletal Manipulations, Low Back Pain
Interventions
Pragmatic Mobilization
Other
Lead sponsor
Youngstown State University
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
3
States / cities
Haslett, Michigan • Old Bridge, New Jersey • Canfield, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 29, 2022 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Manipulation of the Cervical Spine on Pain Biomarkers

NCT03176654
View directory record Official record
Conditions
Neck Pain, Posterior
Interventions
HVLAT manipulation, Sham HVLAT manipulation
Procedure
Lead sponsor
Loma Linda University
Other
Eligibility
20 Years to 45 Years · Female only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Aug 1, 2019 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional

A Comparison of Two Different Methods of Physical Therapy to Treat Acute and Subacute Low Back Pain

NCT02060617
View directory record Official record
Conditions
Low Back Pain
Interventions
Patient Education, Manual therapy of the thoracolumbosacral spine and hips, Motor control exercises, Treatment-Based Classification intervention
Behavioral · Procedure
Lead sponsor
Hendricks Regional Health
Other
Eligibility
18 Years to 80 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Plainfield, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Phase 3 Interventional

Mind Body Intervention for Chronic Lower Back Pain

NCT01894282
View directory record Official record
Conditions
Chronic Lower Back Pain
Interventions
Manual Therapy, Mind Body Intervention
Procedure
Lead sponsor
Canandaigua VA Medical Center
Federal
Eligibility
18 Years to 69 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 31, 2022 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Phase 2 Interventional

Thrust Manipulation Versus Non-Thrust Manipulation

NCT01438203
View directory record Official record
Conditions
Mechanical Low Back Pain
Interventions
Thrust manipulation, Non-thrust manipulation
Procedure
Lead sponsor
Walsh University
Other
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
North Canton, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 5, 2012 · Synced Oct 24, 2026, 3:05 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Mobilization Versus Manipulation on Function in Participants Reporting CAI

NCT03918473
View directory record Official record
Conditions
Ankle Sprains
Interventions
Mobilization with Movement, Thrust Mobilization
Other
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neuroendocrine Changes in Cervical Spinal Manipulation and Mobilization Non-specific Mechanical Neck Pain

NCT04911608
View directory record Official record
Conditions
Neck Pain
Interventions
cervical spinal manipulation, cervical spinal mobilization
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 20, 2023 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional

ED Physical Therapy for Acute Low Back Pain

NCT04921449
View directory record Official record
Conditions
Low Back Pain
Interventions
ED Physical Therapy, Usual Care
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Manual Therapy on Shoulder Function

NCT04513535
View directory record Official record
Conditions
Musculoskeletal Manipulations, Shoulder, Range of Motion, Muscle Strength, Surface Electromyography
Interventions
Thoracic Manipulation, Cervical Manipulation, glenohumeral posterior glide mobilization, Sleeper stretch
Other
Lead sponsor
University of Hartford
Other
Eligibility
18 Years to 55 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
West Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional

Effect of Lower Back Treatment in People With Patellofemoral Pain Syndrome.

NCT01975311
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Lumbopelvic Manipulation, Passive lumbar spine flexion and extension
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years to 50 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 12, 2015 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Thoracic Mobilization on Shoulder Range of Motion

NCT01518504
View directory record Official record
Conditions
Shoulder Range of Motion in Healthy Individuals
Interventions
Thoracic Mobilization, Sham
Other
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 45 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Nov 21, 2012 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional Results available

Chiropractic for Hypertension in Patients

NCT01020435
View directory record Official record
Conditions
Hypertension
Interventions
Spinal Manipulation, Sham Spinal Manipulation
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
21 Years to 75 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 7, 2018 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional

Spinal Manipulation and Dry Needling Versus Conventional Physical Therapy in Patients With Cervicogenic Headache

NCT02373605
View directory record Official record
Conditions
Cervicogenic Headaches
Interventions
Dry Needling,Thrust Manipulation, Exercise,Non-thrust Mobilization
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years to 65 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Montgomery, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 6, 2018 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional

Short-Term Response of Thoracic Spine Manipulation With or Without Trigger Point Dry Needling for Mechanical Neck Pain

NCT02415660
View directory record Official record
Conditions
Neck Pain
Interventions
Thoracic spinal manipulation, Trigger point dry needling, Cervical range of motion exercises, Posterior neck muscle activation exercise, Trigger point dry needling sham, Seirin J-type stainless steel needles, 0-2-0.3 x 40-50 mm
Procedure · Behavioral · Device
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional

Translational Manipulation Under Interscalene Block for Adhesive Capsulitis of the Shoulder (TMACS)

NCT03090555
View directory record Official record
Conditions
Shoulder Adhesive Capsulitis, Frozen Shoulder, Adhesive Capsulitis of Shoulder
Interventions
Translational manipulation, Manual therapy
Procedure
Lead sponsor
Daniel G. Rendeiro
Federal
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 24, 2017 · Synced Oct 24, 2026, 3:05 AM EDT
Recruiting Not applicable Interventional

HVLAT, Electric DN, Exercise Vs. Mobilization, STM, Exercise, TENS for Tension Type Headaches

NCT04609709
View directory record Official record
Conditions
Tension-Type Headache
Interventions
Thrust Manipulation, Electric Dry Needling and Exercise, Non-thrust Mobilization, Soft-Tissue Mobilization, Exercise and TENS
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years to 65 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated May 18, 2025 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Phase 2 Interventional

Cervical Mobilization vs. Standard Physical Therapy for Chronic Neck Pain

NCT01092715
View directory record Official record
Conditions
Neck Pain
Interventions
Spinal mobilization, Massage, Neck exercises
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
20 Years to 80 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 25, 2010 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional Results available

Veterans Response to Dosage in Chiropractic Therapy

NCT04087291
View directory record Official record
Conditions
Low Back Pain, Patient Acceptance of Health Care, Veterans Health
Interventions
Chiropractic Care
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
18 Years and older
Enrollment
766 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
4
States / cities
Los Angeles, California • West Haven, Connecticut • Iowa City, Iowa + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 24, 2026, 3:05 AM EDT
Completed Not applicable Interventional

Changes in Quadriceps Function Following Local or Distant Interventions in Individuals With Patellofemoral Pain

NCT01434966
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Chondromalacia Patellae, Anterior Knee Pain Syndrome
Interventions
Lumbopelvic Manipulation, TENS- Spine, TENS- Knee
Other
Lead sponsor
Creighton University
Other
Eligibility
15 Years to 50 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Dec 14, 2015 · Synced Oct 24, 2026, 3:05 AM EDT