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ClinicalTrials.gov public records Last synced Oct 21, 2026, 8:34 PM EDT

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Showing 1–24 of 70 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Normothermia Clear all
Active, not recruiting No phase listed Observational

An All Comers Registry For Normothermic Ex Vivo Lung Perfusion (EVLP) as Assessment of Donor Lungs for Transplant

NCT05101460
View directory record Official record
Conditions
Lung Transplant
Interventions
XVIVO Perfusion System (XPS™) with STEEN Solution™
Device
Lead sponsor
XVIVO Perfusion
Industry
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2029
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Oct 21, 2026, 8:34 PM EDT
Completed Not applicable Interventional Results available

Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial

NCT00880087
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Therapeutic Hypothermia, Therapeutic Normothermia
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
48 Hours to 18 Years
Enrollment
329 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
25
States / cities
Birmingham, Alabama • Phoenix, Arizona • Loma Linda, California + 21 more
Source: ClinicalTrials.gov public record
Updated Jun 15, 2018 · Synced Oct 21, 2026, 8:34 PM EDT
Completed Not applicable Interventional Results available

Transnasal Induction of Normothermia in Febrile Stroke Patients

NCT03360656
View directory record Official record
Conditions
Stroke, Ischemic, Stroke Hemorrhagic, Fever, Seizures, Metabolic Encephalopathy
Interventions
Transnasal Thermal Regulating Device
Device
Lead sponsor
CoolTech LLC
Industry
Eligibility
18 Years to 95 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2023 · Synced Oct 21, 2026, 8:34 PM EDT
Not yet recruiting Not applicable Interventional

Feasibility of HISA During TURBT for NMIBC

NCT07817173
View directory record Official record
Conditions
Bladder Cancer, Bladder (Urothelial, Transitional Cell) Cancer Resectable (Pre-Cystectomy), Non-muscle Invasive Bladder Cancer (NMIBC), Non-Muscle Invasive Bladder Neoplasms, Non-muscle Invasive Bladder Cancer, Bladder Cancer (BC), Transurethral Resection of Bladdertumors, Transurethral Resection of the Bladder, Non-Muscle Invasive Bladder Carcinoma
Interventions
HISA
Device
Lead sponsor
CAMC Health System
Other
Eligibility
18 Years to 89 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 21, 2026, 8:34 PM EDT
Completed Not applicable Interventional

Deceased Organ Donor Interventions to Protect Kidney Graft Function

NCT02525510
View directory record Official record
Conditions
Brain Death, Organ Donation, Organ Transplant Failure or Rejection, Delayed Graft Function
Interventions
Pump Eligible - Normothermia - Pump Both Kidneys, Pump Eligible - Hypothermia and Pump Right Kidney, Pump Eligible - Hypothermia and Pump Left Kidney, Not Pump Eligible - Normothermia, Not Pump Eligible - Hypothermia
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
1,427 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
7
States / cities
Phoenix, Arizona • San Francisco, California • Denver, Colorado + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2022 · Synced Oct 21, 2026, 8:34 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss

NCT06729632
View directory record Official record
Conditions
Noise Exposure, Noise-induced Hearing Loss, Noise; Adverse Effect, Mild Therapeutic Hypothermia, Cooling, Occupational Exposure, Occupational Health, Hidden Hearing Loss
Interventions
Cold pack-delivered mild therapeutic hypothermia
Device
Lead sponsor
Restorear Devices LLC
Industry
Eligibility
18 Years to 55 Years
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 21, 2026, 8:34 PM EDT
Not yet recruiting Not applicable Interventional

10 Degree C Static Storage in Heart Transplantation

NCT07818941
View directory record Official record
Conditions
Transplant, Failure, Heart, Heart Transplant, Heart Failure
Interventions
10 degree C Static Storage Cooler
Device
Lead sponsor
John Trahanas
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 21, 2026, 8:34 PM EDT
Terminated Not applicable Interventional Results available

WP02 Continued Access Study

NCT04862156
View directory record Official record
Conditions
Liver Transplantation
Interventions
Normothermic Machine Perfusion (NMP)
Device
Lead sponsor
OrganOx Ltd.
Industry
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
7
States / cities
Aurora, Colorado • Maywood, Illinois • Ann Arbor, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2025 · Synced Oct 21, 2026, 8:34 PM EDT
Recruiting Phase 2 Interventional

A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma

NCT06057935
View directory record Official record
Conditions
Malignant Peritoneal Mesothelioma, Peritoneal Mesothelioma, Mesothelioma, Mesothelioma, Malignant, Malignant Mesothelioma
Interventions
Pemetrexed, Cisplatin, Carboplatin
Drug
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
13
States / cities
Chicago, Illinois • Ann Arbor, Michigan • St Louis, Missouri + 10 more
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 21, 2026, 8:34 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

LBNP Tolerance With Skin Warming After Exercise Cold Stress

NCT06279897
View directory record Official record
Conditions
Blood Pressure, Blood Loss
Interventions
Skin Surface Rewarming, Skin Surface Warming, Skin Surface Heating, Skin Surface Cooling
Other
Lead sponsor
University of Colorado, Colorado Springs
Other
Eligibility
18 Years to 40 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Oct 21, 2026, 8:34 PM EDT
Completed Not applicable Interventional Results available

International Randomized Study of the TransMedics Organ Care System (OCS Lung) for Lung Preservation and Transplantation

NCT01630434
View directory record Official record
Conditions
Lung Preservation
Interventions
OCS Lung, Cold flush and storage
Device
Lead sponsor
TransMedics
Industry
Eligibility
18 Years and older
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
8
States / cities
Phoenix, Arizona • Los Angeles, California • San Francisco, California + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Oct 21, 2026, 8:34 PM EDT
Completed Not applicable Interventional

Evaluation of Safety and Effectiveness of The SherpaPak in Donation After Circulatory Death Heart Transplantation

NCT05038943
View directory record Official record
Conditions
Heart Transplant Failure, Determination of Death, Outcomes Research, Extracorporeal Membrane Oxygenation
Interventions
Paragonix SherpaPak Cardiac Transport System
Device
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Oct 21, 2026, 8:34 PM EDT
Completed Not applicable Interventional

Thermal Compression Device for Maintenance of Perioperative Normothermia

NCT02155400
View directory record Official record
Conditions
Hypothermia
Interventions
Bair Hugger, Prototype / Experimental device
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 90 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 2, 2017 · Synced Oct 21, 2026, 8:34 PM EDT
Withdrawn Not applicable Interventional

Reperfusion With Cooling in Cerebral Acute Ischemia II

NCT01728649
View directory record Official record
Conditions
Ischemic Stroke, Hypothermia
Interventions
Mild Hypothermia
Other
Lead sponsor
WellStar Health System
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 13, 2018 · Synced Oct 21, 2026, 8:34 PM EDT
Completed Not applicable Interventional

Safety and Effectiveness of NRP for DCD Heart Transplantation

NCT04626284
View directory record Official record
Conditions
Heart Transplant Failure, Determination of Death, Outcomes Research, Death
Interventions
Heart Transplantation
Procedure
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Oct 21, 2026, 8:34 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients

NCT02338947
View directory record Official record
Conditions
Frail Elderly, Coronary Artery Disease
Interventions
Off-pump coronary-artery bypass grafting, On-pump coronary-artery bypass grafting
Other
Lead sponsor
University of Sao Paulo General Hospital
Other
Eligibility
60 Years and older
Enrollment
440 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 5, 2025 · Synced Oct 21, 2026, 8:34 PM EDT
Completed Not applicable Interventional

Heart Transplantation Using Normothermic Regional Perfusion Donation After Circulatory Death

NCT04284319
View directory record Official record
Conditions
Heart Failure
Interventions
DCD Heart Transplantation Using NRP
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 13, 2023 · Synced Oct 21, 2026, 8:34 PM EDT
Active, not recruiting No phase listed Observational

A Central Preservation and Assessment Service to Optimize Donor Kidney Allocation

NCT06263023
View directory record Official record
Conditions
Organ Preservation
Interventions
Sub-Normothermic Machine Preservation and Assessment
Other
Lead sponsor
34 Lives, PBC
Industry
Eligibility
16 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
8
States / cities
Chicago, Illinois • Indianapolis, Indiana • St Louis, Missouri + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Oct 21, 2026, 8:34 PM EDT
Recruiting Not applicable Interventional

Systemic Hypothermia in Acute Cervical Spinal Cord Injury

NCT02991690
View directory record Official record
Conditions
Spinal Cord Injury, Acute
Interventions
Alsius Icy CoolGuard® Catheter
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 70 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
7
States / cities
Phoenix, Arizona • Miami, Florida • Atlanta, Georgia + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 21, 2026, 8:34 PM EDT
Completed Phase 1 Interventional

Evaluate Safety/Tolerability Intra-Arterial Temozolomide in Patients w/Extremity Melanoma by Isolated Limb Infusion

NCT01127594
View directory record Official record
Conditions
Melanoma
Interventions
Temozolomide
Drug
Lead sponsor
Douglas Tyler
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
3
States / cities
Tampa, Florida • Durham, North Carolina • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2015 · Synced Oct 21, 2026, 8:34 PM EDT
Active, not recruiting No phase listed Observational

Registry Analysis of Deceased Donor Kidney Transplant Outcomes

NCT07530991
View directory record Official record
Conditions
Normothermic Machine Perfusion (NMP) of Deceased Donor Kidneys
Interventions
Not listed
Lead sponsor
Chris Jaynes
Industry
Eligibility
15 Years and older
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 21, 2026, 8:34 PM EDT
Completed Early Phase 1 Interventional

Systemic Normothermia in Intracerebral Hemorrhage (ICH)

NCT02078037
View directory record Official record
Conditions
Intracerebral Hemorrhage
Interventions
Arctic Sun cooling device, Standard of Care
Device · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Oct 21, 2026, 8:34 PM EDT
Terminated Not applicable Interventional Results available

To Study the Effect of Early Cooling in Acute Subdural Hematoma Patients

NCT02064959
View directory record Official record
Conditions
Subdural Hematoma, Traumatic
Interventions
Temperature management Zoll Intravascular Temperature Management device
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
22 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
5
States / cities
Miami, Florida • Atlanta, Georgia • Cincinnati, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 21, 2026, 8:34 PM EDT
Terminated Not applicable Interventional Results available

Warming Blanket Comparison Study

NCT04776954
View directory record Official record
Conditions
Surgery, Temperature Change, Body
Interventions
Forced Air Warming System, Resistive Blanket Warming System
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 90 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 27, 2024 · Synced Oct 21, 2026, 8:34 PM EDT