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ClinicalTrials.gov public records Last synced Sep 13, 2026, 8:43 PM EDT

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Showing 1–19 of 19 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Novel DBS Stimulation Clear all
Recruiting Not applicable Interventional

Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients

NCT07455760
View directory record Official record
Conditions
Parkinson's Disease (PD), Essential Tremor
Interventions
Phoneme sequence learning, Cessation and re-enabling of stimulation of the STN, Cessation and re-enabling of stimulation of the VIM thalamic nucleus, Multisyllabic sequence learning
Behavioral · Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Sep 13, 2026, 8:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Human Intracranial Electrophysiology

NCT05529264
View directory record Official record
Conditions
Epilepsy
Interventions
Memory Tasks, Attention/arousal tasks, Language tasks, Visuospatial tasks, Auditory Tasks, Brain Stimulation, Social Emotional Task, Recording of facial expressions, Judgement/Impulsivity Task
Other · Procedure
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2032
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Sep 13, 2026, 8:43 PM EDT
Active, not recruiting Not applicable Interventional

Combined Cortical/Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder

NCT03184454
View directory record Official record
Conditions
Obsessive Compulsive Disorder
Interventions
Medtronic Percept Deep Brain Stimulation
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
2
States / cities
Charlestown, Massachusetts • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 13, 2026, 8:43 PM EDT
Terminated Not applicable Interventional

Temporally Optimized Patterned Stimulation (TOPS®) Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease

NCT04390867
View directory record Official record
Conditions
Parkinson Disease
Interventions
TOPS1 DBS, TOPS2 DBS, TOPS3 DBS, Standard DBS
Device
Lead sponsor
Deep Brain Innovations LLC
Industry
Eligibility
18 Years to 80 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
3
States / cities
Gainesville, Florida • Chicago, Illinois • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 26, 2022 · Synced Sep 13, 2026, 8:43 PM EDT
Completed Phase 1 Interventional

State-dependent Pathophysiological Oscillations in Parkinson's Disease and Treatment With Deep Brain Stimulation (DBS)

NCT02709148
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Activa PC+S
Device
Lead sponsor
University of Minnesota
Other
Eligibility
45 Years to 75 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 12, 2021 · Synced Sep 13, 2026, 8:43 PM EDT
Recruiting Phase 1 Interventional

Coordinated Reset Deep Brain Stimulation for Essential Tremor

NCT05897775
View directory record Official record
Conditions
Essential Tremor, Upper Extremity Essential Tremor
Interventions
Deep brain stimulation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 13, 2026, 8:43 PM EDT
Recruiting Not applicable Interventional

Novel Brain Stimulation Treatment for Neuropsychiatric Symptoms in Alzheimer's Disease

NCT06835283
View directory record Official record
Conditions
Alzheimer&Amp;#39;s Disease-related Dementia, Alzheimer Disease, rTMS Stimulation
Interventions
Brain Stimulation
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
65 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 13, 2026, 8:43 PM EDT
Completed Not applicable Interventional Results available

Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder

NCT05903495
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Deep Brain Stimulation
Device
Lead sponsor
West Virginia University
Other
Eligibility
22 Years to 50 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Sep 13, 2026, 8:43 PM EDT
Completed No phase listed Observational

Novel Stimulation Patterns for the Treatment of Dystonia

NCT02468843
View directory record Official record
Conditions
Dystonia, Cervical Dystonia
Interventions
Biphasic DBS stimulation, Unified Dystonia Rating Scale, Burke-Fahn- Marsden scale
Device · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 26, 2016 · Synced Sep 13, 2026, 8:43 PM EDT
Completed Not applicable Interventional

Novel Paradigms of Deep Brain Stimulation for Movement Disorders

NCT04563143
View directory record Official record
Conditions
Parkinson Disease
Interventions
Novel DBS Stimulation
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
40 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 28, 2025 · Synced Sep 13, 2026, 8:43 PM EDT
Terminated Not applicable Interventional Results available

Advancing Pre-operative Targeting for Deep Brain Stimulation in the Globus Pallidus Internus

NCT03600740
View directory record Official record
Conditions
Parkinson Disease
Interventions
DBS Programming
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
3
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 28, 2021 · Synced Sep 13, 2026, 8:43 PM EDT
Completed Not applicable Interventional Results available

Chronic Effects of DBS in Parkinson's Disease and Dystonia

NCT01934296
View directory record Official record
Conditions
Parkinson's Disease, Isolated Dystonia
Interventions
Activa PC+S
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
22 Years to 75 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 23, 2023 · Synced Sep 13, 2026, 8:43 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers Results available

Feasibility of Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder

NCT03950492
View directory record Official record
Conditions
Opioid-Related Disorders
Interventions
Deep Brain Simulator
Device
Lead sponsor
West Virginia University
Other
Eligibility
21 Years to 50 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Sep 13, 2026, 8:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neural Correlates of Real World Spatial Navigation in Humans

NCT04874220
View directory record Official record
Conditions
Memory, Delayed
Interventions
Deep Brain Stimulation, Memory and spatial navigation tasks, Physiological Signals, Questionnaires and Assessments
Device · Behavioral
Lead sponsor
Duke University
Other
Eligibility
12 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
2
States / cities
Los Angeles, California • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 13, 2026, 8:43 PM EDT
Terminated Not applicable Interventional Results available

Burst-Type Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease

NCT05753449
View directory record Official record
Conditions
Parkinson Disease, Deep Brain Stimulation
Interventions
Baseline (or standard of care) DBS programming, Burst-type DBS electrical stimulation programming
Device
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years to 85 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 27, 2025 · Synced Sep 13, 2026, 8:43 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Battery-preserving Stimulation Patterns for Deep Brain Stimulation

NCT02569021
View directory record Official record
Conditions
Parkinsons Disease, Essential Tremor
Interventions
Biphasic DBS stimulation, Unified Parkinson's Disease Rating Scale, Tremor Rating Scale, Kinesia accelerometer, Trigno wireless system, GaitRite walking assessment.
Device · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 23, 2016 · Synced Sep 13, 2026, 8:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease

NCT04799470
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Novel DBS stimulation patterns
Device
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2028
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 13, 2026, 8:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor

NCT04212780
View directory record Official record
Conditions
Essential Tremor
Interventions
Medtronic Summit Rechargable (RC)+S, ipsilateral thalamic (VIM+VO) DBS, standard ET DBS, ipsilateral VO
Device · Procedure
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 99 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 13, 2026, 8:43 PM EDT
Completed Not applicable Interventional

Novel DBS Device in Parkinson's Disease

NCT07213999
View directory record Official record
Conditions
Parkinson's Disease (PD)
Interventions
Novel neural recorder
Device
Lead sponsor
University of Minnesota
Other
Eligibility
22 Years to 75 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 13, 2026, 8:43 PM EDT