Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Oct 19, 2026, 3:32 AM EDT

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Showing 145–168 of 584 matching trials from the live ClinicalTrials.gov search.
Conditions
Glaucoma; Drugs, Normal Tension Glaucoma, Primary Open-angle Glaucoma
Interventions
Timolol Maleate, Brimonidine Tartrate
Drug
Lead sponsor
Wills Eye
Other
Eligibility
18 Years to 90 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Completed Not applicable Interventional Results available

Optical Frequency Domain Imaging for Assessing Colonic Polyps

NCT01439087
Conditions
Colonic Polyps
Interventions
MGH Optical Frequency Domain Imaging (OFDI) System
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Terminated Not applicable Interventional Results available

OCT-guided LALAK for KCN

NCT01901614
Conditions
Corneal Opacity, Keratoconus
Interventions
LALAK, IEK, Retrobulbar Block or General Anesthesia, optical coherence tomography (OCT), Topical Anesthesia, femtosecond laser
Procedure · Drug · Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 100 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Portland, Oregon
Completed Not applicable Interventional Accepts healthy volunteers Results available

Wide Field OCT + AI for Positive Margin Rates in Breast Conservation Surgery.

NCT05113927
Conditions
Breast Cancer
Interventions
Selene
Device
Lead sponsor
Perimeter Medical Imaging
Industry
Eligibility
18 Years and older · Female only
Enrollment
613 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
10
States / cities
Jacksonville, Florida • Tampa, Florida • Meadowbrook, Pennsylvania + 6 more
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of the Signal to Noise Ratio at Various Retinal Layers

NCT02982174
Conditions
Healthy Eyes
Interventions
3D OCT-1 Maestro, DRI OCT Triton
Device
Lead sponsor
Topcon Medical Systems, Inc.
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Oakland, New Jersey
Recruiting No phase listed Observational Accepts healthy volunteers

A Study of Noninvasive Methods to Evaluate Skin and Mucosal Conditions

NCT04743362
Conditions
Skin Lesion, Mucosal Lesion
Interventions
Dermoscopic imaging, 3-dimensional total body photography, Confocal microscopy, Optical Coherence Tomography imaging, Ultrasound, Hyperspectral imaging, Electrical impedance spectroscopy, Patient self-imaging
Diagnostic Test
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
Not listed
Enrollment
5,010 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2031
U.S. locations
1
States / cities
New York, New York
Completed No phase listed Observational Results available

Observational Study of OCT in a Patients Undergoing FFR

NCT01663896
Conditions
Coronary Artery Disease
Interventions
OCT stent guidance
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
418 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
15
States / cities
Birmingham, Alabama • La Jolla, California • Orlando, Florida + 12 more
Completed No phase listed Observational Accepts healthy volunteers

Topcon DRI OCT Triton With SS-OCT Angio Software Evaluation Study

NCT04201340
Conditions
Fluorescein Angiography Imaging
Interventions
DRI OCT Triton with SS-OCT Angio software, Cirrus HD-OCT 5000, TRC-50DX
Device
Lead sponsor
Topcon Corporation
Industry
Eligibility
22 Years and older
Enrollment
211 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Augusta, Georgia
Completed No phase listed Observational Accepts healthy volunteers

DISCOVER Study: Microscope-integrated Intraoperative OCT Study

NCT02423213
Conditions
Retinal Diseases, Fuchs Endothelial Dystrophy, Macular Hole, Epiretinal Membrane, Retinal Detachment
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
2,911 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Conditions
Eyes Without Ocular Pathology
Interventions
SD-OCT
Device
Lead sponsor
Optovue
Industry
Eligibility
Not listed
Enrollment
482 participants
Timeline
2019
U.S. locations
5
States / cities
Pomona, California • Fort Lauderdale, Florida • Newark, New Jersey + 2 more
Conditions
Psoriasis Vulgaris
Interventions
Secukinumab
Drug
Lead sponsor
Narrows Institute for Biomedical Research
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Brooklyn, New York
Recruiting Not applicable Interventional Accepts healthy volunteers

Glaucoma Screening to Enhance At-Risk Californians' Health

NCT06854198
Conditions
Glaucoma
Interventions
Glaucoma screening with optical coherence tomography (OCT), color fundus photography, and tonometry, Educational Brochure
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
50 Years and older
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
3
States / cities
Fremont, California • Oakland, California • San Francisco, California
Terminated No phase listed Observational Accepts healthy volunteers

Biomechanics of Optic Neuropathy

NCT02982499
Conditions
Optic Neuropathy
Interventions
magnetic resonance image (MRI), Optical Coherence Tomography (OCT)
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Miami, Florida
Enrolling by invitation No phase listed Observational

Therapeutic EUS Registry

NCT05233631
Conditions
Gastrointestinal Disease
Interventions
Therapeutic Endoscopic ultrasound
Procedure
Lead sponsor
Methodist Health System
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Completed No phase listed Observational Accepts healthy volunteers

Optical Coherence Tomography (OCT) Normative Data Collection Study

NCT02014688
Conditions
Healthy
Interventions
Not listed
Lead sponsor
Heidelberg Engineering GmbH
Industry
Eligibility
18 Years to 90 Years
Enrollment
166 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
New York, New York
Conditions
Sickle Cell Disease
Interventions
Not listed
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
2
States / cities
Charleston, South Carolina
Completed No phase listed Observational

Evaluation of OCT Measurements

NCT01806402
Conditions
Assess Eye Measurements in Patients Having Retina Pathology or Glaucoma
Interventions
Not listed
Lead sponsor
Optovue
Industry
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
3
States / cities
Daly City, California • Petaluma, California • Walnut Creek, California
Conditions
Periorbital Hyperpigmentation
Interventions
Skin imaging, Facial cleanser
Device · Other
Lead sponsor
Allergan
Industry
Eligibility
25 Years to 50 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Irvine, California
Conditions
Vocal Fold Development
Interventions
Children Examined with the OCT Probe
Procedure
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
1 Month to 99 Years
Enrollment
557 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Peripheral Arterial Disease
Interventions
Percutaneous Peripheral Intervention, Optical Coherence Tomography, Ankle Brachial Index, Six minute walk distance, Aspirin, Aspirin + Ticagrelor
Procedure · Device · Other + 1 more
Lead sponsor
Arkansas Heart Hospital
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Little Rock, Arkansas
Conditions
Psoriasis, Psoriatic Arthritis, Psoriatic Nail
Interventions
Etanercept, OCT
Drug · Device
Lead sponsor
OptiSkin Medical
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Conditions
Macular Edema, Epiretinal Membrane, Vitrectomy
Interventions
Dexamethasone
Drug
Lead sponsor
Wills Eye
Other
Eligibility
18 Years to 90 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Encopresis, Autism Spectrum Disorder
Interventions
MIE Treatment, Glycerin Suppository, Treatment as Usual (TAU)
Behavioral · Drug · Combination Product
Lead sponsor
Emory University
Other
Eligibility
5 Years to 12 Years
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Conditions
Transfusion Adverse Reaction, Major Trauma, Blood Product Transfusion for All Conditions
Interventions
Not listed
Lead sponsor
Kocaeli City Hospital
Government
Eligibility
18 Years to 75 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Jacksonville, Florida