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ClinicalTrials.gov public records Last synced Oct 26, 2026, 4:12 PM EDT

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Showing 1–24 of 29 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: OCTA Clear all
Withdrawn Phase 4 Interventional

Optical Coherence Tomography Angiography (OCTA) - Directed PDT Triple Therapy

NCT04075136
View directory record Official record
Conditions
Exudative Age Related Macular Degeneration
Interventions
Ranibizumab, Photodynamic laser treatment (PDT), Triamcinolone Acetonide, verteporfin
Drug · Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
50 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 22, 2024 · Synced Oct 26, 2026, 4:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Additional Heidelberg Engineering SPECTRALIS With OCT Angiography Module (OCTA Module) Scan Types

NCT04604002
View directory record Official record
Conditions
Retinal Vascular, Normal Eyes
Interventions
OCT Angiography, Color Fundus Photography, Optical Coherence Tomography
Device
Lead sponsor
Heidelberg Engineering GmbH
Industry
Eligibility
22 Years and older
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Oct 26, 2026, 4:12 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease

NCT04505618
View directory record Official record
Conditions
Diabetic Retinopathy, Retinal Vein Occlusion, Hypertension,Essential, Retinal Vascular Disorder
Interventions
Swept-Source (SS) OCT Angiography, Spectral-Domain (SD) OCT Angiography, Fundus Imaging, Axial Length Measurement Device
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 99 Years
Enrollment
1,050 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Oct 26, 2026, 4:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Heidelberg Engineering SPECTRALIS With OCT Angiography Module

NCT03279939
View directory record Official record
Conditions
Retinal Vascular, Normal Eyes
Interventions
OCT Angiography, Color Fundus Photography, Fluorescein Angiography, Indocyaine Green Angiography
Device
Lead sponsor
Heidelberg Engineering GmbH
Industry
Eligibility
22 Years and older
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Oct 26, 2026, 4:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Optical Coherence Tomography Angiography in Neurological Disease

NCT06797765
View directory record Official record
Conditions
Octa, Stroke, Subarachnoid Hemorrhage, Intracerebral Hemorrhage
Interventions
OCTA
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 26, 2026, 4:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

OCT Angiography Software Evaluation Study

NCT04701931
View directory record Official record
Conditions
Retina Condition Followed by Fluorescein Angiography Imaging
Interventions
Maestro2 OCTA, Cirrus HD-OCT 5000, TRC-50DX
Device
Lead sponsor
Topcon Corporation
Industry
Eligibility
22 Years and older
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
2
States / cities
Santa Ana, California • Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 5, 2023 · Synced Oct 26, 2026, 4:12 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Evaluation of the Repeatability and Reproducibility of OCTA Image Quality With the Heidelberg Engineering SPECTRALIS With OCT Angiography Module

NCT03530449
View directory record Official record
Conditions
Retinal Vascular, Normal Eyes
Interventions
OCT Angiography, Color Fundus Photography, Optical Coherence Tomography
Device
Lead sponsor
Heidelberg Engineering GmbH
Industry
Eligibility
22 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 28, 2019 · Synced Oct 26, 2026, 4:12 PM EDT
Completed No phase listed Observational

The Eye in Orbit: UCF Adaption

NCT06092359
View directory record Official record
Conditions
Spaceflight Associated Neuro-Ocular Syndrome, SANS
Interventions
Not listed
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Dec 6, 2024 · Synced Oct 26, 2026, 4:12 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Intraoperative OCT Guidance of Intraocular Surgery II

NCT03713268
View directory record Official record
Conditions
Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment, Retinal Disease, Preretinal Fibrosis, Cataract, Ocular Tumor, Strabismus, Healthy
Interventions
Microscope integrated optical coherence tomography
Device
Lead sponsor
Duke University
Other
Eligibility
4 Weeks and older
Enrollment
262 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 26, 2026, 4:12 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy

NCT04737616
View directory record Official record
Conditions
Genitourinary Syndrome of Menopause
Interventions
CO2 laser, OCT
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older · Female only
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Jul 20, 2025 · Synced Oct 26, 2026, 4:12 PM EDT
Recruiting No phase listed Observational

Imaging Retinal Vasculature in Infant Eyes

NCT05558059
View directory record Official record
Conditions
Retinopathy of Prematurity
Interventions
Handheld Optical Coherence Tomography with OCT Angiography
Device
Lead sponsor
Duke University
Other
Eligibility
Up to 2 Months
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Durham, North Carolina • Philadelphi, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 26, 2026, 4:12 PM EDT
Completed No phase listed Observational

Data Collection of OCT and OCTA-based Ocular Measurements

NCT03887104
View directory record Official record
Conditions
Eyes Without Ocular Pathology
Interventions
SD-OCT
Device
Lead sponsor
Optovue
Industry
Eligibility
Not listed
Enrollment
482 participants
Timeline
2019
U.S. locations
5
States / cities
Pomona, California • Fort Lauderdale, Florida • Newark, New Jersey + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Oct 26, 2026, 4:12 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Vaginal Changes After CO2 Laser

NCT06691178
View directory record Official record
Conditions
Genitourinary Syndrome of Menopause
Interventions
Optical coherence tomography (OCT)
Diagnostic Test
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 26, 2026, 4:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Performance Evaluation of OCT and OCT Angiography-based Ocular Measurements (Optical Coherence Tomography)

NCT04437082
View directory record Official record
Conditions
Normal Eyes and Ocular Pathology
Interventions
optical coherence tomography
Device
Lead sponsor
Optovue
Industry
Eligibility
18 Years and older
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Tahlequah, Oklahoma
Source: ClinicalTrials.gov public record
Updated Sep 20, 2021 · Synced Oct 26, 2026, 4:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of the Heidelberg Engineering SPECTRALIS With Flex Module for In-vivo Imaging in the Supine Position

NCT04661124
View directory record Official record
Conditions
Retinal Disease, Healthy Eyes
Interventions
SPECTRALIS, SPECTRALIS with Flex Module
Device
Lead sponsor
Heidelberg Engineering GmbH
Industry
Eligibility
22 Years and older
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Oct 26, 2026, 4:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Caffeine Consumption in Glaucoma Patients and Healthy Subjects

NCT03675412
View directory record Official record
Conditions
Glaucoma, Primary Open Angle
Interventions
Caffeine tablet
Dietary Supplement
Lead sponsor
Wills Eye
Other
Eligibility
18 Years to 90 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 26, 2026, 4:12 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Retinal Microanatomy in Retinopathy of Prematurity (BabySTEPS2)

NCT04995341
View directory record Official record
Conditions
Retinopathy of Prematurity
Interventions
Investigational ultracompact OCT and OCTA system, retinal photographs
Device
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
236 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
2
States / cities
Durham, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 26, 2026, 4:12 PM EDT
Not listed Not applicable Interventional

Combined Effects of Diabetes Self-Management Education and Nutritional Supplementation on Visual Function and Retinopathy

NCT04120077
View directory record Official record
Conditions
Diabetes Mellitus, Diabetic Retinopathy
Interventions
EyePromise DVS, EyePromise DVS plus EyePromise EZTears
Dietary Supplement
Lead sponsor
ZeaVision, LLC
Industry
Eligibility
18 Years to 85 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 23, 2021 · Synced Oct 26, 2026, 4:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Imaging of Retinochoroidal Vasculature in Patients Being Assessed for Cardiovascular Disease

NCT05082402
View directory record Official record
Conditions
Cardiovascular Diseases, Retina; Change
Interventions
Swept Source Optical Coherence Tomography Angiography
Diagnostic Test
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 95 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 26, 2026, 4:12 PM EDT
Completed Phase 4 Interventional Results available

The IAI-OCTA Study; a Study of OCT-Angiography Analysis Efficacy

NCT03022292
View directory record Official record
Conditions
Wet Macular Degeneration
Interventions
Aflibercept Ophthalmic, optovue angiovue
Drug · Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
50 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 6, 2022 · Synced Oct 26, 2026, 4:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Precision of OCT and OCTA-based Ocular Measurements

NCT03859310
View directory record Official record
Conditions
Normal Eyes and Ocular Pathology
Interventions
SD-OCT
Device
Lead sponsor
Optovue
Industry
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Marysville, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Oct 26, 2026, 4:12 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

OCT Angiography and NRAI in Dementia

NCT03761381
View directory record Official record
Conditions
Alzheimer Disease, Dementia, Mild Cognitive Impairment
Interventions
Optical Coherence Tomography Angiography (OCTA) Imaging, Noninvasive Retinal Amyloid Imaging (NRAI)
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
55 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 12, 2025 · Synced Oct 26, 2026, 4:12 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Retinal Imaging in Neurodegenerative Disease

NCT03233646
View directory record Official record
Conditions
Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis, Huntington Disease, Lewy Body Dementia, Frontotemporal Dementia, Amyotrophic Lateral Sclerosis (ALS), APOE-4 Positive, Traumatic Brain Injury, Concussion, Post-Traumatic Stress Disorder, Down Syndrome, Neuro-Degenerative Disease, Normal Cognition
Interventions
Retinal and Choroidal Imaging
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Oct 26, 2026, 4:12 PM EDT
Recruiting No phase listed Observational

Investigating the Effect of Ocrelizumab in African Americans and Caucasians With Relapsing Multiple Sclerosis

NCT04458688
View directory record Official record
Conditions
Multiple Sclerosis, Relapsing-Remitting
Interventions
Observation of Ocrelizumab as Treatment in RRMS Patients
Other
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2030
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 6, 2022 · Synced Oct 26, 2026, 4:12 PM EDT