Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Oct 24, 2026, 3:28 AM EDT

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Showing 361–384 of 2,682 matching trials from the live ClinicalTrials.gov search.
Conditions
Lumbar Spinal Stenosis, Lumbar Spinal Instability, Lumbar Spine Degeneration
Interventions
Standard analgesia use [Oxygen], Standard analgesia use [Hydromorphone], Standard analgesia use [Volatile Anesthesia], Standard analgesia use [Fentanyl], Multi-modal pain management [Acetaminophen + Gabapentin], Multi-modal pain management [Fentanyl], Multi-modal pain management [Intravenous Ketamine], Multi-modal pain management [Valium + Gabapentin]
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Collaborative Care for Alcohol Use Disorders in the Patient-centered Medical Home

NCT02885311
Conditions
Alcohol-Related Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse, Alcohol Use Disorders
Interventions
Motivation Enhancement Therapy, Modified Behavioral Self-Control Therapy, Naltrexone, Brief Advice, Referral to specialty substance use disorder treatment
Behavioral · Drug · Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 75 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Great Neck, New York
Conditions
Tonsillitis, Pain
Interventions
Codeine with acetaminophen, Tramadol suspension
Drug
Lead sponsor
Children's Hospitals and Clinics of Minnesota
Other
Eligibility
4 Years to 15 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Analgesic Response
Interventions
morphine sulfate, hydrocodone, hydromorphone HCI, oxycodone, buprenorphine, oral tablet placebo, sublingual tablet placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
20 Years to 50 Years · Male only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Los Angeles, California
Completed Not applicable Interventional Accepts healthy volunteers Results available

TACUNA (Traditions and Connections for Urban Native Americans)

NCT04617938
Conditions
Opioid Use, Alcohol Drinking, Marijuana Use
Interventions
TACUNA plus Wellness Circle, Opioid Education Workshop
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years to 25 Years
Enrollment
541 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
3
States / cities
Los Angeles, California • Santa Monica, California
Conditions
Opioid-Related Disorders
Interventions
Buprenorphine/naloxone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2000
U.S. locations
1
States / cities
Los Angeles, California
Conditions
Drug Overdose, Opioid-Related Disorders
Interventions
Diagnostic algorithms that detects/predicts hypoventilation
Device
Lead sponsor
RTM Vital Signs, LLC
Industry
Eligibility
18 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Recruiting Not applicable Interventional Accepts healthy volunteers

Mobile Neurofeedback for Low Back Pain

NCT05669027
Conditions
Chronic Low Back Pain
Interventions
Neurofeedback, Sham (Placebo Control)
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years to 90 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Completed Phase 1 Interventional Accepts healthy volunteers

An Evaluation of The Absolute Bioavailability of TH104

NCT06198686
Conditions
Healthy
Interventions
Nalmefene
Drug
Lead sponsor
Tharimmune Inc
Industry
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Las Vegas, Nevada
Conditions
Opioid Use, Chronic Pain
Interventions
Brief Mindfulness-Based Intervention (BMBI), Control/Nutrition Education
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Conditions
Arthritis, Pain, Cognitive Impairment
Interventions
long acting oxycodone, extra strength acetaminophen
Drug
Lead sponsor
University of Chicago
Other
Eligibility
65 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Completed No phase listed Observational

Perinatal Opioid Use

NCT04049032
Conditions
Opioid Use, Pregnancy
Interventions
In-Person Perinatal OUD Treatment, Perinatal OUD Treatment via Telemedicine
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Charleston, South Carolina
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Efficacy of Extended Release Tramadol for Treating Prescription Opioid Withdrawal

NCT00980044
Conditions
Substance Withdrawal Syndrome
Interventions
Tramadol, Placebo
Drug
Lead sponsor
Michelle Lofwall
Other
Eligibility
18 Years to 55 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Lexington, Kentucky
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Buprenorphine for Prisoners

NCT00574067
Conditions
Heroin Addiction
Interventions
Buprenorphine +OTP, Buprenorphine +CHC, Counseling +OTP, Counseling +CHC
Drug
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years to 60 Years
Enrollment
213 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
2
States / cities
Baltimore, Maryland • Jessup, Maryland
Conditions
Opioid-Related Disorders, Pain, Chronic
Interventions
hatha yoga, health education
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Fall River, Massachusetts
Conditions
Depression, Major Depressive Disorder
Interventions
Naltrexone 50 Mg Oral Tablet, Placebo oral tablet
Drug
Lead sponsor
Marta Peciña, MD PhD
Other
Eligibility
18 Years to 55 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Substance Use Disorder
Interventions
Virtual POC Toxicology Test
Diagnostic Test
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
2
States / cities
West Haven, Connecticut • Leeds, Massachusetts
Conditions
Substance Use Disorders, Opioid Use Disorder, Alcohol Use Disorder, Cocaine Use Disorder, Methamphetamine-dependence
Interventions
EDITOR (CBOT with olfactory stimulants, OFC tasks & remote monitoring of treatment compliance), CBOT with olfactory stimulants & OFC tasks, CBOT Sham
Combination Product
Lead sponsor
Evon Medics LLC
Industry
Eligibility
18 Years to 80 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Rockville, Maryland
Conditions
Post Operative Pain
Interventions
Oxycodone oral capsule
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
19 Years to 40 Years · Female only
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Roanoke, Virginia
Conditions
Cancer, Breakthrough Cancer Pain
Interventions
PPP001, Morphine sulfate or Hydromorphone or Oxycodone
Drug
Lead sponsor
Tetra Bio-Pharma
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Berlin, New Jersey
Recruiting Phase 3 Interventional

Opioid-Free Orthopaedics

NCT04659317
Conditions
Pain, Pain, Postoperative
Interventions
Oxycodone 5 mg Oral Tablet, Placebo oral tablet
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
3
States / cities
Atlanta, Georgia • Tucker, Georgia
Completed Not applicable Interventional

Prescribe to Save Lives

NCT03175640
Conditions
Opioid-Related Disorders, Drug Overdose
Interventions
Implementation intervention
Behavioral
Lead sponsor
Baystate Medical Center
Other
Eligibility
Not listed
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
Springfield, Massachusetts • Providence, Rhode Island
Recruiting No phase listed Observational Accepts healthy volunteers

Timing of Opioid Administration and Postoperative Respiratory Depression.

NCT07227389
Conditions
Respiratory Complications, Opioid Induced Respiratory Depression, Postoperative Respiratory Complications
Interventions
Respiratory volume monitoring
Diagnostic Test
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 85 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Detroit, Michigan
Conditions
Opioid Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
Interventions
TRTME
Behavioral
Lead sponsor
T. John Winhusen, PhD
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cincinnati, Ohio