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ClinicalTrials.gov public records Last synced Oct 24, 2026, 8:14 PM EDT

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Showing 481–504 of 2,682 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: OPIOID Clear all
Recruiting Phase 1Phase 2 Interventional

(2R,6R)-Hydroxynorketamine for the Treatment of Neuropathic Pain

NCT05864053
View directory record Official record
Conditions
Pain, Neuropathic
Interventions
Ketamine, (2R,6R)-hydroxynorketamine, Saline
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Not applicable Interventional Results available

Remote Methadone Ingestion Surveillance Trial (RMIST)

NCT05259501
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
RMIST
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Recruiting Phase 2 Interventional

Local Anesthesia for Facial Fractures

NCT06429501
View directory record Official record
Conditions
Pain Management
Interventions
Bupivacaine/Epinephrine, Saline
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Completed No phase listed Observational Results available

Feasibility and Validation of a Standard Phenotyping Assessment Battery

NCT03495869
View directory record Official record
Conditions
Opioid-use Disorder, Cocaine Use Disorder, Marijuana Use Disorder, Healthy Controls
Interventions
Not listed
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 70 Years
Enrollment
368 participants
Timeline
2018 – 2020
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Oct 24, 2026, 8:14 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

NCT06552741
View directory record Official record
Conditions
Substance Use Disorder, Alcohol Use Disorder
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 99 Years
Enrollment
10,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2047
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Phase 3 Interventional

Evaluating the Safety and Tolerability of OraVescent Fentanyl for Opioid Tolerant Patients With Noncancer Related Breakthrough Pain

NCT00228605
View directory record Official record
Conditions
Low Back Pain, Migraine, Diabetic Neuropathies, Osteoarthritis
Interventions
OraVescent Fentanyl
Drug
Lead sponsor
Cephalon
Industry
Eligibility
18 Years to 80 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
38
States / cities
Calera, Alabama • Hoover, Alabama • Phoenix, Arizona + 29 more
Source: ClinicalTrials.gov public record
Updated May 9, 2014 · Synced Oct 24, 2026, 8:14 PM EDT
Completed No phase listed Observational

Development of a Tracheal Sound Sensor

NCT05506267
View directory record Official record
Conditions
Respiratory Insufficiency, Opioid Overdose, Hypoventilation
Interventions
Trachea Sound Sensor (TSS)
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 18, 2022 · Synced Oct 24, 2026, 8:14 PM EDT
Terminated Early Phase 1 Interventional Results available

Behavioral Effects of Drugs Inpatient 44 Neurobehavioral Mechanisms of Opioid Choice

NCT06312657
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Drug Cue, Money, Withdrawal, Remifentanil
Behavioral · Drug
Lead sponsor
Joshua A. Lile, Ph.D.
Other
Eligibility
18 Years to 50 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Sprix for Postoperative Pain Control Following Gynecologic Surgery

NCT04444830
View directory record Official record
Conditions
Post Operative Pain Control, Narcotic Use, Pelvic Organ Prolapse, Urinary Incontinence , Stress, Surgery
Interventions
Sprix
Drug
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 29, 2022 · Synced Oct 24, 2026, 8:14 PM EDT
Completed No phase listed Observational

The Adolescent Surgery Experience: A Mixed Methods Analysis

NCT05482919
View directory record Official record
Conditions
Pain, Postoperative, Pain, Pain, Acute, Pain, Chronic, Adolescent Behavior, Opioid Use
Interventions
Baseline Survey, Post Operative Surveys, Qualitative Interviews
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
11 Years to 21 Years
Enrollment
501 participants
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 26, 2024 · Synced Oct 24, 2026, 8:14 PM EDT
Recruiting Not applicable Interventional

Technology-Enhanced Therapy vs. Medication Monitoring for Buprenorphine Retention in Pregnant Persons

NCT06999811
View directory record Official record
Conditions
Opioid Use Disorder, Pregnancy
Interventions
Empowering Pregnant Women and People Receiving medications for opioid use disorder (EMPWR), Medication monitoring (control)
Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Not yet recruiting Early Phase 1 Interventional Accepts healthy volunteers

Impacts of Opioids on Respiratory Drive During Sleep

NCT06854211
View directory record Official record
Conditions
Opioids, Obstructive Sleep Apnea (OSA)
Interventions
Morphine p.o., Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Recruiting Not applicable Interventional

EXPANDED SCOPE for Parent Grant Entitled, "Peer Recovery Support Services for Individuals in Recovery Residences on MOUD"

NCT06696157
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
PRSS intervention for MOUD initiation
Behavioral
Lead sponsor
Potomac Health Foundations
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2025 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Not applicable Interventional Results available

INTEGRA: A Vanguard Study of Health Service Delivery in a Mobile Health Delivery Unit

NCT04804072
View directory record Official record
Conditions
HIV Infections, Drug Use, Opioid Use, Opioid-use Disorder
Interventions
Medication for opioid-use disorder (MOUD) for opioid-use disorder (OUD), HIV testing, HIV treatment for participants living with HIV not already in care, PrEP for participants without HIV, Testing and referral for vaccination or treatment for hepatitis A virus (HAV) and hepatitis B virus (HBV), Testing and referral for treatment for hepatitis C virus (HCV), Sexually transmitted infection (STI) testing and treatment, Primary care, Harm reduction services, Peer navigation, COVID-19 testing and referral for further evaluation, care and/or treatment
Drug · Diagnostic Test · Other + 1 more
Lead sponsor
HIV Prevention Trials Network
Network
Eligibility
18 Years and older
Enrollment
447 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
5
States / cities
Los Angeles, California • Washington D.C., District of Columbia • The Bronx, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Early Phase 1 Interventional

Trial Comparing a Multi-Modal Pain Protocol With and Without Opioids Following Total Joint Arthroplasty

NCT03845881
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Oxycodone, Placebo Oral Tablet
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 89 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 30, 2020 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Not applicable Interventional

Tai Chi Easy for Opioid Use Disorder, Anxiety, and Chronic Pain

NCT05850533
View directory record Official record
Conditions
Opioid Use Disorder, Chronic Pain, Anxiety
Interventions
Virtual Tai Chi Easy
Behavioral
Lead sponsor
Asana Recovery
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Costa Mesa, California
Source: ClinicalTrials.gov public record
Updated Oct 12, 2023 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Not applicable Interventional

Program for Pain & Prescription Opioid Use in Pregnancy

NCT02804152
View directory record Official record
Conditions
Pain, Opioid Abuse, Pregnancy
Interventions
CBT for Chronic Pain in Pregnancy
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 6, 2022 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Perinatal Care and Medication Assisted Treatment: Carbon/Emery Counties

NCT04448015
View directory record Official record
Conditions
Opioid-use Disorder, Pregnancy Related
Interventions
Perinatal Opioid Use Disorder Education and Enhanced Perinatal Care
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Price, Utah
Source: ClinicalTrials.gov public record
Updated Nov 10, 2020 · Synced Oct 24, 2026, 8:14 PM EDT
Not yet recruiting Not applicable Interventional

Improving Access to Opioid Use Disorder Treatment Among Marginalized Patients With a Tailored Telehealth Intervention

NCT06341608
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Telehealth for opioid use disorder treatment delivery
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Phase 2 Interventional

Dose-ranging Study to Assess Safety and Efficacy of SP-333 for the Treatment of Opioid-induced Constipation (OIC)

NCT01983306
View directory record Official record
Conditions
Constipation
Interventions
SP-333 1 mg, SP-333 3 mg, SP-333 6 mg, Placebo
Drug
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
292 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
42
States / cities
Huntsville, Alabama • Mobile, Alabama • Phoenix, Arizona + 35 more
Source: ClinicalTrials.gov public record
Updated May 7, 2021 · Synced Oct 24, 2026, 8:14 PM EDT
Completed No phase listed Observational

Effects of Environmental Factors on Opiate Drug Choice in Opioid Dependent Individuals.

NCT00608504
View directory record Official record
Conditions
Heroin Dependence, Opioid-Related Disorders
Interventions
Not listed
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 55 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 5, 2012 · Synced Oct 24, 2026, 8:14 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Cannabis and Opioid Use Disorder

NCT05729932
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Inhaled vaporized cannabis, Intransal opioid
Drug
Lead sponsor
Shanna Babalonis, PhD
Other
Eligibility
18 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Terminated Phase 2Phase 3 Interventional

Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy

NCT05597878
View directory record Official record
Conditions
Pain Management, Opioid Use, Prostate Cancer
Interventions
Oxycodone, Acetaminophen, Ketamine, Ketorolac
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
40 Years to 75 Years · Male only
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Oct 24, 2026, 8:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Postoperative Opt-In Narcotic Treatment Study

NCT04710069
View directory record Official record
Conditions
Postoperative Pain, Narcotic Use, Analgesia, Endocrine Surgery, Opioid Use, Opioid Abuse
Interventions
POINT
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 4, 2021 · Synced Oct 24, 2026, 8:14 PM EDT