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ClinicalTrials.gov public records Last synced Oct 26, 2026, 2:14 PM EDT

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Showing 145–168 of 1,439 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: OPTIMAL Clear all
Recruiting Not applicable Interventional

Investigating Inhibitory Control Networks in Parkinson's Disease

NCT04735458
View directory record Official record
Conditions
Parkinson Disease
Interventions
Procedure/Surgery: Response Inhibition and Deep Brain Stimulation in Parkinson's disease
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Protein in Feeding Strategies to Accelerate Muscle Recovery From ACL Reconstruction

NCT03492021
View directory record Official record
Conditions
Rehabilitative Nutrition for Muscle Recovery From ACL Reconstruction
Interventions
Diet Intervention_AP-CPT, Diet Intervention_PP-PPT
Other
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 50 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 28, 2022 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Phase 4 Interventional

Atomoxetine Pilot Study in Preschool Children With ADHD

NCT00517647
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder
Interventions
ATMX
Drug
Lead sponsor
University of Arizona
Other
Eligibility
3 Years to 5 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 9, 2012 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Vision-based Speed of Processing Cognitive Training and Mild Cognitive Impairment

NCT02559063
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Vision-based speed of processing training, Mental leisure activities
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 2, 2019 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Collagen Vitamin C Dose Response Performance

NCT03293004
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Hydrolyzed collagen, Vitamin C, Optimized Hydrolyzed Collagen and Vitamin C, Gummy Placebo
Dietary Supplement
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 25 Years · Male only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2018 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Not applicable Interventional Results available

Optimizing Current and Electrode Montage for Transcranial Direct Current Stimulation in Stroke Patients

NCT02763826
View directory record Official record
Conditions
Stroke
Interventions
transcranial direct current stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 80 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 13, 2021 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Identifying Decision Making Parameters in Healthy Volunteers and Anxiety Patients

NCT05092971
View directory record Official record
Conditions
Anxiety, Healthy Volunteers
Interventions
Shock or startle device
Device
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 50 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 22, 2024 · Synced Oct 26, 2026, 2:14 PM EDT
Active, not recruiting Phase 1Phase 2 Interventional

Study of Safety, Tolerability and Efficacy of PBGM01 in Pediatric Participants With GM1 Gangliosidosis

NCT04713475
View directory record Official record
Conditions
GM1 Gangliosidosis, GM1 Gangliosidosis, Type I, GM1 Gangliosidosis, Type 2, Beta-Galactosidase-1 (GLB1) Deficiency
Interventions
PBGM01
Biological
Lead sponsor
Gemma Biotherapeutics
Industry
Eligibility
1 Month to 24 Months
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
4
States / cities
Oakland, California • Minneapolis, Minnesota • New Brunswick, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluation of the Safety and Efficacy of CosmetaLife™ for the Correction of Nasolabial Folds

NCT00414544
View directory record Official record
Conditions
Facial Wrinkles
Interventions
CosmetaLife, Restylane
Device
Lead sponsor
Cosmeta
Industry
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
5
States / cities
Tracy, California • Roswell, Georgia • Chestnut Hill, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2011 · Synced Oct 26, 2026, 2:14 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Sensory-Play Based (SenPlay) Intervention for Young Children With or At Risk for ADHD

NCT05222321
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder
Interventions
Sensory-Play Based (SenPlay) Intervention, Spontaneous, Free Play
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
36 Months to 71 Months
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Yukon, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 10, 2024 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Not applicable Interventional Results available

Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability

NCT01615484
View directory record Official record
Conditions
Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis, Bronchiectasis, Sarcoidosis, Pulmonary Hypertension, Alpha-1 Antitrypsin Deficiency
Interventions
Transplantation of lungs obtained from Non-Heart-Beating Donors (NHBDs) after ex-vivo perfusion w/ STEEN Solution™, STEEN Solution™
Procedure · Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
15 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 8, 2018 · Synced Oct 26, 2026, 2:14 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Healthy Volunteer Study to Evaluate the Impact of Various Common Interventions on Venous Pressure Signal Captured by PIVA

NCT04324593
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Peripheral intravenous analysis (PIVA) algorithm
Device
Lead sponsor
Baxter Healthcare Corporation
Industry
Eligibility
18 Years to 55 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 1, 2021 · Synced Oct 26, 2026, 2:14 PM EDT
Completed No phase listed Observational Results available

PiPT in ADSM With MSD

NCT05132400
View directory record Official record
Conditions
Chronic Pain, Musculoskeletal Diseases or Conditions
Interventions
Psychological-informed Physical Therapy (PiPT) Training
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 64 Years
Enrollment
427 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated May 11, 2025 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Treatments for Fathers With ADHD and Their At-Risk Children (Fathers Too)

NCT02675400
View directory record Official record
Conditions
Attention Deficit/Hyperactivity Disorder (ADHD)
Interventions
Vyvanse, Behavioral Parent Training, Methylphenidate
Drug · Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
21 Years to 55 Years · Male only
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 12, 2018 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Don't Throw Your Heart Away: Patient Study 4

NCT04809051
View directory record Official record
Conditions
Cardiac Transplant Disorder
Interventions
Stratified Transplant Survival Metric, SRTR Information Format
Other
Lead sponsor
Carnegie Mellon University
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Not applicable Interventional

An Intensive Lifestyle Intervention Program in CKD (Move to Health 2)

NCT02842957
View directory record Official record
Conditions
Kidney Disease
Interventions
Lifestyle Intervention
Behavioral
Lead sponsor
Springfield College
Other
Eligibility
18 Years to 75 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Not applicable Interventional

The Family Grocery Pilot: Optimal Defaults in Online Grocery Shopping Among Families

NCT05899634
View directory record Official record
Conditions
Obesity
Interventions
Defaults
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Oct 26, 2026, 2:14 PM EDT
Terminated Phase 2 Interventional Results available

Safety and Efficacy of RLX030 in Pregnant Women With Pre- Eclampsia

NCT01566630
View directory record Official record
Conditions
Pre-eclampsia
Interventions
Placebo, RLX030
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years to 40 Years · Female only
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
4
States / cities
Mobile, Alabama • Lexington, Kentucky • Louisville, Kentucky + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 5, 2015 · Synced Oct 26, 2026, 2:14 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers

Improving Functionality in Older People

NCT03611049
View directory record Official record
Conditions
Vitamin D Deficiency
Interventions
High dose Vitamin D3, Low dose Vitamin D3
Dietary Supplement
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
65 Years to 89 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Oct 26, 2026, 2:14 PM EDT
Completed No phase listed Observational

Optimal Improvement of Vein Graft Patency Long Term by the Implementation Of Novel Endoscopic Harvesting Techniques

NCT01697176
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Not listed
Lead sponsor
Cardiopulmonary Research Science and Technology Institute
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Dallas, Texas • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Oct 22, 2014 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Epicatechin-rich Cocoa on Collagen Synthesis

NCT03214133
View directory record Official record
Conditions
Collagen Synthesis
Interventions
Epicatechin-rich cocoa dose response, Epicatechin-rich cocoa vs placebo on performance
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 25 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Aug 3, 2021 · Synced Oct 26, 2026, 2:14 PM EDT
Completed No phase listed Observational

Magnetic Resonance Imaging of Lymph Nodes Using Ferumoxytol in Patients With Primary Prostate or Breast Cancer

NCT00087347
View directory record Official record
Conditions
Breast Cancer, Prostate Cancer
Interventions
ferumoxytol, magnetic resonance imaging
Drug · Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 14, 2013 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Phase 4 Interventional Results available

Optimal Blood Pressure Treatment Thresholds Postpartum

NCT06069102
View directory record Official record
Conditions
Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Hypertension, Eclampsia, Gestational Hypertension, Cardiovascular Diseases, Toxemia, Pregnancy Complications, Vascular Diseases, Hypertension, Pregnancy Induced, Hypertension;Pre-Eclamptic
Interventions
Usual care, Tight blood pressure control
Drug
Lead sponsor
Alisse Hauspurg
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 26, 2026, 2:14 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Optimal Bupivacaine Dose for Initiation of Labor Epidural Techniques

NCT04814537
View directory record Official record
Conditions
Labor Pain, Analgesia
Interventions
Bupivacaine Hydrochloride
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 26, 2026, 2:14 PM EDT