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ClinicalTrials.gov public records Last synced Oct 26, 2026, 5:46 AM EDT

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Showing 457–480 of 664 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: OPTIMIZE Clear all
Completed No phase listed Observational Accepts healthy volunteers

Early MRI Prediction of Crohns

NCT03340519
View directory record Official record
Conditions
Crohn Disease
Interventions
MR Imaging
Device
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
11 Years to 25 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Oct 26, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Effect of Epidural Stimulation on Muscle Activation and Sensory Perception

NCT04157400
View directory record Official record
Conditions
Chronic Pain
Interventions
Intraoperative Parameter Testing, Proprioception Testing During Stimulation, Gait Analysis During Stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 15, 2023 · Synced Oct 26, 2026, 5:46 AM EDT
Not listed Phase 1Phase 2 Interventional

Improving Primary Care to Prevent Childhood Obesity

NCT00377767
View directory record Official record
Conditions
Overweight in Preschool Age Children, Risk of Overweight in Preschool Age Children
Interventions
To change structure and roles of primary care teams to optimize prevention of obesity
Behavioral
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
2 Years to 6 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 18, 2006 · Synced Oct 26, 2026, 5:46 AM EDT
Recruiting Not applicable Interventional

Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal

NCT04477330
View directory record Official record
Conditions
Stroke
Interventions
Transcranial direct current stimulation (tDCS), Ankle motor training, High intensity interval speed based treadmill training (HIISTT)
Other · Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 26, 2026, 5:46 AM EDT
Not listed Not applicable Interventional

Home-based Transitional Telecare for Older Veterans

NCT04045054
View directory record Official record
Conditions
Telemedicine, Veterans Health, Physical Activity, Mobility
Interventions
Link Team
Behavioral
Lead sponsor
VA Ann Arbor Healthcare System
Federal
Eligibility
50 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 8, 2021 · Synced Oct 26, 2026, 5:46 AM EDT
Recruiting Phase 2 Interventional

Lipid Infusions to Optimize Nutrition Trial

NCT06915441
View directory record Official record
Conditions
Bronchopulmonary Dysplasia, Neurodevelopmental Impairment
Interventions
SOLE, MOLE
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
12 Hours to 28 Weeks
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 26, 2026, 5:46 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Implementation of Evidence-Based Strategy (PC TEACH) for the Optimization of HPV Vaccination in Rural Primary Care

NCT06256718
View directory record Official record
Conditions
Human Papillomavirus Infection
Interventions
Educational Intervention
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
203 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 26, 2026, 5:46 AM EDT
Recruiting Phase 3 Interventional

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

NCT06498635
View directory record Official record
Conditions
Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8
Interventions
Biospecimen Collection, Computed Tomography, Durvalumab, Patient Observation, Questionnaire Administration
Procedure · Biological · Other
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2039
U.S. locations
281
States / cities
Jonesboro, Arkansas • Beverly Hills, California • Dublin, California + 224 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 26, 2026, 5:46 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Gathering Evidence on Best Practices for Lay Rescuer CPR Training

NCT05908500
View directory record Official record
Conditions
Cardiac Arrest, Out-Of-Hospital
Interventions
CPR Training, CPR Manikin Type
Behavioral · Device
Lead sponsor
University of Nevada, Reno
Other
Eligibility
Not listed
Enrollment
2,100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Oct 26, 2026, 5:46 AM EDT
Enrolling by invitation No phase listed Observational

EnCoRe MoMS: Engaging Communities to Reduce Morbidity From Maternal Sepsis (Aim 2)

NCT06148532
View directory record Official record
Conditions
Maternal Sepsis, Infections
Interventions
Not listed
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
400,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Oct 26, 2026, 5:46 AM EDT
Recruiting Not applicable Interventional

Group-based Comprehensive Lifestyle Program for Women With Metastatic Breast Cancer

NCT07179809
View directory record Official record
Conditions
Metastatic Breast Cancer
Interventions
Demographics/Lifestyle Survey
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 26, 2026, 5:46 AM EDT
Completed Phase 2 Interventional

Electrical Stimulation of the Internal Capsule for Intractable Depression

NCT01069952
View directory record Official record
Conditions
Depression
Interventions
Deep Brain Stimulation System
Device
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2002
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 24, 2012 · Synced Oct 26, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Study of Refeeding to Optimize iNpatient Gains

NCT02488109
View directory record Official record
Conditions
Anorexia Nervosa
Interventions
Higher Calorie Refeeding, Lower Calorie Refeeding
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
12 Years to 24 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
Palo Alto, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 24, 2021 · Synced Oct 26, 2026, 5:46 AM EDT
Withdrawn Not applicable Interventional

Cardiac Output Monitoring in Burn Patients

NCT02404597
View directory record Official record
Conditions
Burns
Interventions
NICOM (non-invasive cardiac output monitor)
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 28, 2018 · Synced Oct 26, 2026, 5:46 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD)

NCT03963817
View directory record Official record
Conditions
Age Related Macular Degeneration
Interventions
adaptive optics AO-OCT/AF instrument
Diagnostic Test
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
60 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Oct 26, 2026, 5:46 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Study Comparing Prandial Insulin Aspart vs. Technosphere Insulin in Patients With Type 1 Diabetes on Multiple Daily Injections: Investigator-Initiated A Real-life Pilot Study-STAT Study

NCT03143816
View directory record Official record
Conditions
Diabetes Mellitus, Type 1
Interventions
Technosphere insulin
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 22, 2022 · Synced Oct 26, 2026, 5:46 AM EDT
Completed No phase listed Observational

Characterizing In Vivo Oral Lesion Impedances

NCT05430477
View directory record Official record
Conditions
Oral Lesion
Interventions
Electrical impedance imaging using Non-Significant Risk device (EII probe)
Device
Lead sponsor
Ryan J. Halter
Other
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Oct 26, 2026, 5:46 AM EDT
Completed Not applicable Interventional Results available

Perioperative Mental Health in Orthopedic Surgery

NCT05697835
View directory record Official record
Conditions
Orthopedic Surgery, Older Adults, Depression, Anxiety
Interventions
Behavioral activation, Medication optimzation, Care as usual
Behavioral · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 26, 2026, 5:46 AM EDT
Completed Phase 4 Interventional Results available

Drug and Non-Drug Treatment Of Severe Migraine

NCT00910689
View directory record Official record
Conditions
Migraine Headache
Interventions
Propranolol or nadolol, Placebo control, Behavioral Migraine Management (BMM), Optimal Acute Therapy
Drug · Behavioral
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 65 Years
Enrollment
232 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
2
States / cities
Athens, Ohio • Westerville, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 22, 2016 · Synced Oct 26, 2026, 5:46 AM EDT
Completed Not applicable Interventional

Spaced Education to Optimize Prostate Cancer Screening

NCT01168323
View directory record Official record
Conditions
Prostate Cancer
Interventions
Online spaced education
Behavioral
Lead sponsor
Harvard University Faculty of Medicine
Other
Eligibility
18 Years and older
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 9, 2010 · Synced Oct 26, 2026, 5:46 AM EDT
Terminated Not applicable Interventional Results available

ECG for Programming in CRT

NCT03936608
View directory record Official record
Conditions
Systolic Heart Failure, Cardiac Resynchronization Therapy, Electrocardiography
Interventions
Programming individualized RV-LV pacing offset to optimize ECG, Nominally programming CRT device without RV-LV offset
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 100 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Oct 26, 2026, 5:46 AM EDT
Recruiting Not applicable Interventional

Robotic Rehabilitation of the Upper Limb in Subacute Stroke

NCT06839482
View directory record Official record
Conditions
Stroke
Interventions
Robotic Assisted Upper Limb Rehabilitation, Control Group (CG)
Device · Other
Lead sponsor
IRCCS San Raffaele Roma
Other
Eligibility
18 Years to 85 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Elkins Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Oct 26, 2026, 5:46 AM EDT
Active, not recruiting Not applicable Interventional

Mobile Video Interpretation to Optimize Communication Across Language Barriers

NCT05591586
View directory record Official record
Conditions
Limited English Proficiency
Interventions
Web based educational modules, mobile video interpreting (mVI) access
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Not listed
Enrollment
6,669 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 23, 2026 · Synced Oct 26, 2026, 5:46 AM EDT
Recruiting Phase 2 Interventional

Investigation to Understand and Optimize Psilocybin

NCT06512194
View directory record Official record
Conditions
Depression
Interventions
Psilocybin, Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Sham taVNS
Drug · Device
Lead sponsor
Charles Raison
Other
Eligibility
18 Years to 70 Years
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Edwards, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Oct 26, 2026, 5:46 AM EDT